Impaired mitochondrial turnover Sample Clauses

Impaired mitochondrial turnover. In order to maintain an efficient energy production within the cell, defective mitochondria, including those with CxI deficiency, require routine replacement. This typically occurs via a specialised form of autophagy, known as mitophagy (xx Xxxxx & Xxxxxxxxxxx 2013). As mentioned above, loss of xxxxxx and PINK1 results in a reduction in the neuron’s ability to recycle defective mitochondria. The precise consequences of impaired mitophagy in PD are difficult to fully elucidate due to the fact that a lot of the studies investigating mitophagy in PD were conducted in non-mammalian (Poole et al. 2008, Xxx & Xx 2010) and non- neuronal (Xxxxx et al. 2007, Xxxxxxxxx et al. 2010) cells. However, impaired mitophagy in PD is thought to result in the accumulation of defective mitochondria. Consequently, this would be expected to result in sub-optimal ATP synthesis, a failure to remove mtDNA mutations and increased ROS production, eventually leading to cell death (Xxxx & Xxxx 2009, xx Xxxxx & Xxxxxxxxxxx 2013).