The pathophysiology of PD Sample Clauses

The pathophysiology of PD. 1.2.1. Inherited vs non-inherited PD Broadly speaking, PD can be classified into 2 categories: familial and sporadic. Familial PD refers to inherited forms of the disease that cluster within families. Due to the inherited nature of familial PD, its cause is often identifiable by the discovery of one or more mutated genes. On the other hand, people with sporadic PD do not appear to have a family history of the disease and, while some monogenic forms of sporadic PD do exist (discussed in more detail below), about 90% of PD cases occur idiopathically without a definable cause (Xxxxxx & Xxxxx 2009). However, while the cause of sporadic PD tends to be poorly defined, there is a large degree of physiological overlap between the monogenic and apparently non-genetic forms of PD. This has led to a large amount of research being undertaken into the genetic forms of the disease in an effort to understand the mechanisms that could also be occurring in sporadic PD.
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