Common use of Integration of Documents; Supremacy Clause in Contracts

Integration of Documents; Supremacy. This First Amendment contains the full understanding and agreement between the parties. The parties hereto intend that this First Amendment operates to amend and modify the Existing Lease, and that those two documents shall be interpreted conjunctively; with any express conflict between the two to be resolved in favor of the stated terms of this First Amendment. Except as modified hereby, all other terms and conditions of the Existing Lease shall remain unchanged and enforceable in a manner consistent with this First Amendment, including Lessee’s right to assignment and subletting of the Expansion Space as set forth therein. This Agreement shall be governed by the laws of the Commonwealth of Massachusetts. Any provisions deemed unenforceable shall be severable, and the remainder of this First Lease Amendment and the Existing Lease shall be enforceable in accordance with their terms. [Signature Pages Follow] LESSOR RIVERTECH ASSOCIATES II, LLC By: Rivertech Associates II, Inc., its Manager By: /s/ Xxxxxx Xxxxxxx Name: Xxxxxx Xxxxxxx Title: President LESSEE DIMENSION THERAPEUTICS, INC. By: /s/ Xxxxxxxx Xxxxxxx its duly authorized, Chief Executive Officer Name: Xxxxxxxx Xxxxxxx Title: CEO DIMENSION THERAPEUTICS, INC. FIRST LEASE AMENDMENT EXHIBIT A DIMENSION THERAPEUTICS, INC. FIRST LEASE AMENDMENT EXHIBIT B DIMENSION THERAPEUTICS Floor Two 000 Xxxxxxxx Xxxxx Xxxxxxxxx, XX October 20, 2014 Final changes in bold. SCOPE OF LANDLORDS WORK FOR LAB AND OFFICES ON FLOOR TWO Administrative Area Partitions: Partitions for three new offices are to be added as indicated on the plans. Walls of new offices shall be insulated and extend to approximately 6” above the existing suspended ceiling. Existing office walls are comprised of gwb over steel studs and extend from floor to the underside of the suspended ceiling. The walls demising the Administrative areas from adjacent tenancies and R&D areas extend to the underside of the deck above and are constructed to have a one hour fire rating. All new walls will be finished with two coats water based paint. Existing walls shall be patched and repainted as necessary but maintain existing paint color. A new partion will be constructed approximately 8’ from the existing main glass entry, extend 6” above the suspended ceiling, have three approximately 24”x24” clear glass vision panel insets and extend approximately 10’ from the existing demising wall. Glass Panels: Where they exist, glass panels to remain. Entry: Existing glass entry to remain. Doors: All hardware are lever handles with brushed stainless finish. New doors in offices 111, 112, & 113 will be solid oak to match building standard. New office door hardware will consist of passage function latchsets with brushed stainless finish. Floors: All carpeted areas in the administrative which are affected by construction will be protected and reused. 4” vinyl cove base will be installed at intersection of new walls and carpet/vct in new offices. VCT will be installed in an area adjacent to the new kitchenette. Ceilings: All existing ceiling tiles will remain or be replaced as necessary. Any damaged ceiling tiles will be replaced with matching ceiling tiles. Any damage to ceiling grid will be repaired. Lighting: Existing fluorescent lights will remain and be relocated and supplemented as necessary to accommodate the new configuration. All existing fluorescent lights will be inspected to insure proper functioning and be repaired or replaced as necessary.

Integration of Documents; Supremacy. This First Amendment contains the full understanding and agreement between the parties. The parties hereto intend that this First Amendment operates Amended and Restated Lease Agreement incorporate the provisions of the original Lease (to amend the extent not specifically superseded by the terms and modify conditions hereof) and that conjunctively these documents constitute the Existing Leasefull and complete agreement as between the parties. The following provisions of the Original Lease are not applicable to the Extended Term: Section 1 (Term); Section 2 (to the extent of the Schedule of Annual Base Rent); Section 3 (as to the first through fourth paragraphs, only); Section 4 (as to the first, and second, and fourth paragraphs, only); Section 22 (solely to the extent that those two documents the notice addresses appearing on the execution pages hereof supersede); Section 33 (which is wholly superseded by Section 5 hereof); and Exhibit B (which is wholly superseded by Exhibit B as it is attached hereto). As a condition to the effectiveness of this Agreement, LESSOR shall be interpreted conjunctively; with any express conflict between provide to LESSEE either (a) the two written acknowledgement of the current mortgagee that the existing Subordination, Non-Disturbance and Attornment Agreement non-disturbance agreement remains in effect and applies to be resolved this Amended and Restated Lease Agreement or (b) a new Subordination, Non-Disturbance and Attornment Agreement in the form attached hereto in favor of LESSEE executed by the stated terms of current mortgagee with respect to this First Amendment. Except as modified hereby, all other terms Amended and conditions of the Existing Restated Lease shall remain unchanged and enforceable in a manner consistent with this First Amendment, including Lessee’s right to assignment and subletting of the Expansion Space as set forth thereinAgreement. This Agreement shall be governed by the laws of the Commonwealth of Massachusetts. Any provisions deemed unenforceable shall be severable, and the remainder of this First Lease Amendment and the Existing Lease Agreement shall be enforceable in accordance with their its terms. [Signature Pages Follow] LESSOR This Agreement may only be modified m writing, signed by both parties. Unless otherwise provided herein, all capitalized terms used herein shall have the same meaning as set forth in the Original Lease. Witness our hands and seals the first date above written. RIVERTECH ASSOCIATES II, LLC By: By Rivertech Associates IIAssociates, Inc., Inc. its duly authorized Manager By: /s/ Xxxxxx Xxxxxxx NameXxxxxx Xxxxxxx, President Notice Address: 000 Xxxxxxxx Xxxxxx Xxxxxxx Title0xx Xxxxx Xxxxxx, Xxxxxxxxxxxxx 00000 with a copy to: President LESSEE DIMENSION THERAPEUTICSXxxxxxxxxxx X. Xxxxxxx, Esq. Xxxxxxxxx Xxxxxxxxxx & Xxxx LLP Prudential Tower 000 Xxxxxxxx Xxxxxx Xxxxxx, Xxxxxxxxxxxxx 00000 GENET1X PHARMACEUTICALS, INC. By: /s/ Xxxxxxxx Xxxxxx X. Xxxxxxx its duly authorizedauthorized (Attached Secretary/Clerk’s Certificate As To Authority) Notice Address: 000 Xxxxxxxx Xxxxx 0xx Xxxxx Xxxxxxxxx, Chief Executive Officer NameXxxx. with a copy to: Xxxxxxxx Xxxxxxx Title: CEO DIMENSION THERAPEUTICSGENETIX PHARMACEUTICALS, INC. FIRST AMENDED AND RESTATED LEASE AMENDMENT EXHIBIT A DIMENSION THERAPEUTICS, INC. FIRST LEASE AMENDMENT AGREEMENT REVISED EXHIBIT B DIMENSION THERAPEUTICS Floor Two Operating Expenses 2006 000 Xxxxxxxx Xxxxx Xxxxxxxxx, XX October 20, 2014 Final changes in bold. SCOPE OF LANDLORDS WORK FOR LAB AND OFFICES ON FLOOR TWO Administrative Area PartitionsXxxxx—Riverside Technology Center DESCRIPTION PSF HEAT $ 0.54 BUILDING ELECTRIC $ 2.01 WATER & SEWER $ 0.21 ELEVATOR MAINTENANCE $ 0.15 PARKING/CAFE EXPENSE $ 0.26 RUBBISH REMOVAL $ 0.14 INSURANCE $ 0.36 GROUNDS CARE $ 0.27 LEGAL/ACCT/ADMIN $ 0.11 JANITORIAL SERVICES $ 0.50 GENERAL MAINTENANCE $ 1.38 HVAC MAINTENANCE $ 0.50 LIFE SAFETY SYSTEMS $ 0.11 MANAGEMENT $ 3.28 Total Operating Expenses $ 9.82 Real Estate Taxes (FY 2007) $ 4.63 Note: Partitions Actual numbers for three new offices are to be added as indicated 2007 and all subsequent years will vary based on the plans. Walls of new offices shall be insulated actual costs and extend to approximately 6” above the existing suspended ceiling. Existing office walls are comprised of gwb over steel studs and extend from floor to the underside of the suspended ceiling. The walls demising the Administrative areas from adjacent tenancies and R&D areas extend to the underside of the deck above and are constructed to have a one hour fire rating. All new walls will be finished with two coats water based paint. Existing walls shall be patched and repainted as necessary but maintain existing paint color. A new partion will be constructed approximately 8’ from the existing main glass entry, extend 6” above the suspended ceiling, have three approximately 24”x24” clear glass vision panel insets and extend approximately 10’ from the existing demising wall. Glass Panels: Where they exist, glass panels to remain. Entry: Existing glass entry to remain. Doors: All hardware are lever handles with brushed stainless finish. New doors in offices 111, 112, & 113 will be solid oak to match building standard. New office door hardware will consist of passage function latchsets with brushed stainless finish. Floors: All carpeted areas in the administrative which are affected by construction will be protected and reused. 4” vinyl cove base will be installed at intersection of new walls and carpet/vct in new offices. VCT will be installed in an area adjacent to the new kitchenette. Ceilings: All existing ceiling tiles will remain or be replaced as necessary. Any damaged ceiling tiles will be replaced with matching ceiling tiles. Any damage to ceiling grid will be repaired. Lighting: Existing fluorescent lights will remain and be relocated and supplemented as necessary to accommodate the new configuration. All existing fluorescent lights will be inspected to insure proper functioning and be repaired or replaced as necessaryexpenses incurred.

Integration of Documents; Supremacy. This First Amendment Fifth Lease Amendment, incorporating the terms and conditions of the Original Lease and all prior amendments through the Fourth Lease Amendment, contains the full understanding and agreement between the parties. The parties hereto intend that this First Fifth Lease Amendment operates to amend and modify the Existing Lease, and that those two prior documents constituting the Existing Lease shall be interpreted conjunctively; with any express conflict between the two those prior documents and this Fifth Lease Amendment to be resolved in favor of the stated terms of this First Fifth Lease Amendment. Except as modified hereby, all other terms and conditions of the Existing Lease shall remain unchanged and enforceable in a manner consistent with this First Fifth Lease Amendment, including Lessee’s right to assignment and subletting of the Expansion Space as set forth therein. This Agreement shall be governed by the laws of the Commonwealth of Massachusetts. Any provisions deemed unenforceable shall be severable, and the remainder of this First Fifth Lease Amendment and the Existing Lease shall be enforceable in accordance with their terms. [Signature Pages Follow] LESSOR RIVERTECH ASSOCIATES II, LLC By: Rivertech Associates II, Inc., its Manager By: /s/ Xxxxxx Xxxxxxx Name: Xxxxxx Xxxxxxx Title: President LESSEE DIMENSION THERAPEUTICSAXCELLA HEALTH, INC. , By: /s/ Xxxxxx Xxxxxxxx Its duly authorized President/Vice President By: /s/ Xxxxxx Xxxxxxx its Its duly authorized, Chief Executive Officer Name: Xxxxxxxx Xxxxxxx Title: CEO DIMENSION THERAPEUTICS, INC. FIRST LEASE AMENDMENT EXHIBIT A DIMENSION THERAPEUTICS, INC. FIRST LEASE AMENDMENT EXHIBIT B DIMENSION THERAPEUTICS Floor Two 000 Xxxxxxxx Xxxxx Xxxxxxxxx, XX October 20, 2014 Final changes in bold. SCOPE OF LANDLORDS WORK FOR LAB AND OFFICES ON FLOOR TWO Administrative Area Partitions: Partitions for three new offices are to be added as indicated on the plans. Walls of new offices shall be insulated and extend to approximately 6” above the existing suspended ceiling. Existing office walls are comprised of gwb over steel studs and extend from floor to the underside of the suspended ceiling. The walls demising the Administrative areas from adjacent tenancies and R&D areas extend to the underside of the deck above and are constructed to have a one hour fire rating. All new walls will be finished with two coats water based paint. Existing walls shall be patched and repainted as necessary but maintain existing paint color. A new partion will be constructed approximately 8’ from the existing main glass entry, extend 6” above the suspended ceiling, have three approximately 24”x24” clear glass vision panel insets and extend approximately 10’ from the existing demising wall. Glass Panels: Where they exist, glass panels to remain. Entry: Existing glass entry to remain. Doors: All hardware are lever handles with brushed stainless finish. New doors in offices 111, 112, & 113 will be solid oak to match building standard. New office door hardware will consist of passage function latchsets with brushed stainless finish. Floors: All carpeted areas in the administrative which are affected by construction will be protected and reused. 4” vinyl cove base will be installed at intersection of new walls and carpetauthorized Treasurer/vct in new offices. VCT will be installed in an area adjacent to the new kitchenette. Ceilings: All existing ceiling tiles will remain or be replaced as necessary. Any damaged ceiling tiles will be replaced with matching ceiling tiles. Any damage to ceiling grid will be repaired. Lighting: Existing fluorescent lights will remain and be relocated and supplemented as necessary to accommodate the new configuration. All existing fluorescent lights will be inspected to insure proper functioning and be repaired or replaced as necessary.Ass’t Treasurer

Integration of Documents; Supremacy. This First Amendment Second Lease Extension Agreement contains the full understanding and agreement between the parties. The parties hereto intend that this First Amendment Second Lease Extension Agreement operates to amend and modify the Existing Lease, and that those two documents shall be interpreted conjunctively; with any express conflict between the two to be resolved in favor of the stated terms of this First AmendmentSecond Lease Extension Agreement. Except as modified hereby, all other terms and conditions of the Existing Lease shall remain unchanged and enforceable in a manner consistent with this First Amendment, including Lessee’s right Second Lease Extension Agreement. Defined terms used in this Second Lease Extension Agreement that are not otherwise defined herein shall have the definitions ascribed to assignment and subletting of such terms in the Expansion Space as set forth thereinExisting Lease. This Agreement shall be governed by the laws of the Commonwealth of Massachusetts. Any provisions deemed unenforceable shall be severable, and the remainder of this First Second Lease Amendment Extension Agreement and the Existing Lease shall be enforceable in accordance with their terms. [Signature Pages Follow] Witness our hands and seals as of the date first written above. LESSOR RIVERTECH ASSOCIATES II, LLC By: Rivertech Associates II, Inc., its Manager By: /s/ Xxxxxx Xxxxxxx Name: Xxxxxx Xxxxxxx Title: President its duly authorized Manager LESSEE DIMENSION THERAPEUTICSBLUEBIRD BIO, INC. By: /s/ Xxxxxxxx Xxxx Xxxxxxx its duly authorized, Chief Executive Officer Nameauthorized President/Vice President By: Xxxxxxxx /s/ Xxxxxxx Title: CEO DIMENSION THERAPEUTICSX. Xxxxx its duly authorized Treasurer/Ass’t Treasurer BLUEBIRD BIO, INC. FIRST SECOND LEASE AMENDMENT EXTENSION AND MODIFICATION AGREEMENT EXHIBIT A DIMENSION THERAPEUTICS, INC. FIRST LEASE AMENDMENT EXHIBIT B DIMENSION THERAPEUTICS See Attached BLUEBIRD BIO Floor Two Four 000 Xxxxxxxx Xxxxx Xxxxxxxxx, XX October 20AUGUST 13, 2014 Final changes in bold. 2012 SCOPE OF LANDLORDS WORK FOR LAB AND OFFICES ON FLOOR TWO Administrative Area ADDITIONAL PREMISES ONLY *** Space will be emptied of all furnishing prior to move-in date Partitions: Partitions for three new offices are to be added removed and relocated as indicated on the accompanying plans. Walls of Existing and new offices shall be insulated and extend to approximately 6” above the existing suspended ceiling. Existing office walls are comprised of gwb over steel studs and extend from floor to the underside of the suspended ceiling. The walls demising the Administrative areas from adjacent tenancies and R&D areas extend to the underside of the deck above and are constructed to have a one hour fire ratingabove. All new walls will be finished with two coats water based paint. The entire office space will have 2 new coats of water based paint to match bluebird’s existing space color scheme. Existing walls shall be patched “lavatory” room will have plumbing removed and repainted remain as necessary but maintain existing paint colorstorage room. A New storage room will have VCT removed and new partion will be constructed approximately 8’ from the existing main glass entry, extend 6” above the suspended ceiling, have three approximately 24”x24” clear glass vision panel insets and extend approximately 10’ from the existing demising wallmatching carpeting. Glass Panels: Where they exist, glass panels to remain. Glass panels from 4131 and 4130 will be removed to allow for the respective doors to be relocated. This is to allow for the modern-fold partition to be stored on the wall in between the doors when it is not separating 4131 and 4130. Entry: Existing glass entry to remain. Doors: Existing doors will be reused and relocated as necessary provided they have existing full lite glazing. All hardware are lever handles with brushed stainless finish. New office doors in offices 111, 112, & 113 will be solid oak to match building standardinstalled with full lite glazing where applicable. New All office doors will have full lite glazing. Office and conference room door hardware will consist be comprised of passage function latchsets with brushed stainless finish. Storage room latchsets will be comprised of class room function latchsets with brushed stainless finish. Floors: All carpeted areas in the administrative which are affected by construction will be protected re-carpeted with matching Xxxx Contract nylon loop carpet from “Turn Key Collection. 4” vinyl cove base has been installed at intersection of walls and reusedcarpet/vct. Vinyl tile installed in the floor of the kitchenette to remain. VCT will be removed from the storage area and be replaced with matching carpeting, 4” vinyl cove base will be installed at intersection of new walls and carpet/vct in new offices. VCT will be installed in an area adjacent to the new kitchenettestorage areas as well as areas affected by construction. Ceilings: All existing ceiling tiles will remain or be replaced as necessary. Any damaged ceiling tiles will be replaced with matching ceiling tiles. Any damage to ceiling grid will be repaired. Lighting: Existing All existing fluorescent lights will remain and be relocated and supplemented as necessary to accommodate the new configuration. All existing fluorescent lights will be inspected to insure proper functioning and be repaired or replaced as necessary. HVAC: The base building HVAC distribution system will be inspected and adjusted as necessary to assure distribution, airflow, and proper operation of thermostats and variable air volume (VAV) boxes. There will be a redistribution of the system to accommodate 5 separate zones as indicated on the drawings. This work will be designed by landlord’s consulting engineer. The office area will be provided with make-up air from either the 30 ton roof mounted MUA unit or house systems in order to provide fresh air to the office and maintain positive pressure with respect to R&D space. A pre-construction balancing/CFM reading will be done to show existing air balance in the space. The landlord’s engineer will perform HVAC load calculations to take into account insulation, square footage, occupancy and equipment heat loss to determine heating and cooling loads. Expected equipment and occupant load shall be provided to the landlord’s engineer for this purpose. The space will be balanced according to these calculations. All balancing will be conducted by a XXXX certified balancing technician. Pre-construction balancing, engineering calculations and post-construction “as built” documentation/balancing reports will be provided to the tenant or the tenant’s designee. The new space will conform to ASHRAE Standard 55 “Thermal Environmental Conditions for Human Occupancy”. All HVAC equipment shall be inspect by the landlord and replaced as necessary. The lessee accepts the existing HVAC system provided that it is in good working order, that it conforms to ASHRAE Standard 55, and that a reasonable temperature is maintained in the office areas. In the event during the lease term the HVAC system does not meet the aforementioned prerequisites the landlord will provide a new system which will be replaced at the Landlord’s cost. The tenant will be responsible for maintaining and repairing all tenant specific supplemental mechanical equipment beyond the 6 month warranty period. Tenant specific mechanical equipment will be delivered in good operating condition. Kitchenette: The kitchenette will remain undisturbed. Electrical: Existing electrical outlets throughout the administration area and the office space in the R&D area in the form of existing and new 1l0v outlets to remain. All utilities servicing the tenant’s premises and equipment are separately metered and will be read monthly by the landlord for reimbursement by the tenant. New outlets will be installed to accommodate the new layout. Each office will have a minimum of 3 120/20a 5-20R receptacles. All electrical circuits will be labeled via labels at the outlet, junction box, safety switch, or other corresponding electrical equipment and a corresponding label on the electrical panel indicating the appropriate circuit breaker. Furnishings: No reception desk cubicles, work stations or furniture of any sort shall be provided by the landlord. Specialties: A demountable partition by Modernfold or equal will be installed as indicated in the plans. This wall will have a “Dry Erase” surface from floor to ceiling. BluebirdBio or their designee will have access to the space during the renovation to inspect progress and that the work being done conforms to this scope. Fire Protection: Fire protection will be added as needed and required by Massachusetts Building cod, NFPA and local Fire Code. Work included in this scope will comply with the Massachusetts Building Code and NFPA. BluebirdBio Final Scope of Work 8/13/2012 R&D AREA Demolition: Existing lab benches, plumbing, piping, vinyl tile, doors and walls required to be removed to accommodate new plan will be removed. The existing 6’ hood shall be capped and removed from the premises. The existing wing wall adjacent to the hood shall be removed per attached drawings. The entire R&D area will have 2 coats water based paint applied per Bluebird bio’s existing paint scheme New Partitions: New partitions enclosing new tissue culture suites shall consist of existing walls comprised of 5/8”gwb over 3 1/2” steel studs and extending from floor to 6” above the underside of the suspended ceiling. Walls and trim will be finished with two coats water based paint. Paint finish in tissue culture rooms to be semi gloss. The tissue culture rooms will be separated from the main laboratory by a hallway as indicated in the drawing. Existing glass panels in the exterior offices shall be removed. The walls surrounding the “radio-isotope room” shall extend to the underside of the deck above and have an additional layer of 5/8” gwb applied to each accessible side of the wall. Walls will be constructed to the deck above with 2 layers of 5/8” GWB. Walls will be completely sealed with appropriate sealant in order to prevent any contamination of adjoining spaces. Work will be consistent with attached drawing and keynotes. The existing exterior window in the office to become the darkroom shall be blacked out via either applied opaque vinyl or an opaque panel which will prevent any light from entering via the window. Doors: Where indicated on the drawings, Xxxxxx Ultra-Clean Series Atmospheric 110 doors with push plate activators and safety scan sensors will be installed. Buttons to activate the doors will be installed.

Integration of Documents; Supremacy. This First Amendment contains the full understanding and agreement between the parties. The parties hereto intend that this First Lease Amendment operates shall operate to amend and modify the Existing documents comprising the Lease, and that those two documents the Lease and this First Lease Amendment shall be interpreted conjunctively; with any express conflict between the two such that LESSEE's material default under either one shall be deemed to be resolved in favor a material default under both, entitling LESSOR to exercise its rights cumulatively and to procure eviction and recovery of the stated terms of this First Amendmentall space leased to LESSEE, simultaneously, and to pursue damages under all instruments conjunctively. Except as expressly modified hereby, all other terms and conditions of the Existing Lease shall remain unchanged and enforceable in a manner consistent with this First Lease Amendment, including Lessee’s right ; the terms and conditions of this First Lease Amendment to assignment and subletting govern any inconsistent provisions in any of the Expansion Space as set forth thereinconstituent Lease documents. This Agreement shall be governed by the laws of the Commonwealth of Massachusetts. Any provisions deemed unenforceable shall be severable, and the remainder of this First Lease Amendment and the Existing Lease Agreement shall be enforceable in accordance with their its terms. [Signature Pages Follow] LESSOR This Agreement may only be modified in writing, signed by both parties. Unless otherwise provided herein, all capitalized terms used herein shall have the same meaning as set forth in the Lease. * = CONFIDENTIAL TREATMENT REQUESTED: MATERIAL HAS BEEN OMITTED AND FILED SEPARATELY WITH THE COMMISSION. Witness our hands and seals the first date above written. RIVERTECH ASSOCIATES IIASSOCIATES, LLC By: Rivertech Associates II, Inc., its Manager By: /s/ Xxxxxx Xxxxxxx Name: Xxxxxx Xxxxxxx Title: President LESSEE DIMENSION THERAPEUTICS------------------------------- XXXXXX XXXXXXX, MANAGER NEOGENESIS DRUG DISCOVERY, INC. ByBY: /s/ Xxxxxxxx Xxxxxxx Xxxxx X. Xxxxxx -------------------------------------- its duly authorizedauthorized VICE PRESIDENT - FINANCE & CFO (Attached Secretary/Clerk's Certificate As To Authority) * = CONFIDENTIAL TREATMENT REQUESTED: MATERIAL HAS BEEN OMITTED AND FILED SEPARATELY WITH THE COMMISSION. OPERATING EXPENSE ESCALATION NEOGENESIS (Period 10/1/97 - 9/30/03) 1996 2000 DESCRIPTION (BASE) AMOUNT ------------------------------- ------- ------- HEAT 24,935 33,489 WATER & SEWER 13,302 16,171 ELEVATOR MAINT 12,064 15,307 PARKING/CAFE EXPENSE 11,563 28,402 RUBBISH REMOVAL 15,967 25,966 INSURANCE 25,302 21,269 GROUNDS CARE 9,088 8,171 LEGAL/ACCT/ADMIN 4,216 4,407 JANITORIAL SERVICES 77,403 100,467 GENERAL MAINTENANCE 76,060 47,814 HVAC MAINTENANCE 16,422 56,381 LIFE SAFTEY SYSTEMS 3,787 5,460 MANAGEMENT (*) 226,020 275,578 ------- ------- 516,129 638,882 ======= ======= (*) 5% GROSS INCOME, Chief Executive Officer NameNOT LOWER THAN BASE AMOUNT * = CONFIDENTIAL TREATMENT REQUESTED: Xxxxxxxx Xxxxxxx Title: CEO DIMENSION THERAPEUTICS, INC. FIRST LEASE AMENDMENT EXHIBIT A DIMENSION THERAPEUTICS, INC. FIRST LEASE AMENDMENT EXHIBIT B DIMENSION THERAPEUTICS Floor Two 000 Xxxxxxxx Xxxxx Xxxxxxxxx, XX October 20, 2014 Final changes in bold. SCOPE OF LANDLORDS WORK FOR LAB MATERIAL HAS BEEN OMITTED AND OFFICES ON FLOOR TWO Administrative Area Partitions: Partitions for three new offices are to be added as indicated on the plans. Walls of new offices shall be insulated and extend to approximately 6” above the existing suspended ceiling. Existing office walls are comprised of gwb over steel studs and extend from floor to the underside of the suspended ceiling. The walls demising the Administrative areas from adjacent tenancies and R&D areas extend to the underside of the deck above and are constructed to have a one hour fire rating. All new walls will be finished with two coats water based paint. Existing walls shall be patched and repainted as necessary but maintain existing paint color. A new partion will be constructed approximately 8’ from the existing main glass entry, extend 6” above the suspended ceiling, have three approximately 24”x24” clear glass vision panel insets and extend approximately 10’ from the existing demising wall. Glass Panels: Where they exist, glass panels to remain. Entry: Existing glass entry to remain. Doors: All hardware are lever handles with brushed stainless finish. New doors in offices 111, 112, & 113 will be solid oak to match building standard. New office door hardware will consist of passage function latchsets with brushed stainless finish. Floors: All carpeted areas in the administrative which are affected by construction will be protected and reused. 4” vinyl cove base will be installed at intersection of new walls and carpet/vct in new offices. VCT will be installed in an area adjacent to the new kitchenette. Ceilings: All existing ceiling tiles will remain or be replaced as necessary. Any damaged ceiling tiles will be replaced with matching ceiling tiles. Any damage to ceiling grid will be repaired. Lighting: Existing fluorescent lights will remain and be relocated and supplemented as necessary to accommodate the new configuration. All existing fluorescent lights will be inspected to insure proper functioning and be repaired or replaced as necessaryFILED SEPARATELY WITH THE COMMISSION.

Integration of Documents; Supremacy. This First Amendment Second Lease Extension Agreement contains the full understanding and agreement between the parties. The parties hereto intend that this First Amendment Second Lease Extension Agreement operates to amend and modify the Existing Lease, and that those two documents shall be interpreted conjunctively; with any express conflict between the two to be resolved in favor of the stated terms of this First AmendmentSecond Lease Extension Agreement. Except as modified hereby, all other terms and conditions of the Existing Lease shall remain unchanged and enforceable in a manner consistent with this First Amendment, including Lessee’s right Second Lease Extension Agreement. Defined terms used in this Second Lease Extension Agreement that are not otherwise defined herein shall have the definitions ascribed to assignment and subletting of such terms in the Expansion Space as set forth thereinExisting Lease. This Agreement shall be governed by the laws of the Commonwealth of Massachusetts. Any provisions deemed unenforceable shall be severable, and the remainder of this First Second Lease Amendment Extension Agreement and the Existing Lease shall be enforceable in accordance with their terms. [Signature Pages Follow] Witness our hands and seals as of the date first written above. LESSOR RIVERTECH ASSOCIATES II, LLC By: Rivertech Associates II, Inc., its Manager By: /s/ Xxxxxx Xxxxxxx Name: Xxxxxx Xxxxxxx Title: President its duly authorized Manager LESSEE DIMENSION THERAPEUTICSBLUEBIRD BIO, INC. By: /s/ Xxxxxxxx Xxxx Xxxxxxx its duly authorized, Chief Executive Officer Nameauthorized President/Vice President By: Xxxxxxxx /s/ Xxxxxxx Title: CEO DIMENSION THERAPEUTICSX. Xxxxx its duly authorized Treasurer/Ass’t Treasurer BLUEBIRD BIO, INC. FIRST SECOND LEASE AMENDMENT EXTENSION AND MODIFICATION AGREEMENT EXHIBIT A DIMENSION THERAPEUTICS, INC. FIRST LEASE AMENDMENT EXHIBIT B DIMENSION THERAPEUTICS See Attached BLUEBIRD BIO Floor Two Four 000 Xxxxxxxx Xxxxx Xxxxxxxxx, XX October 20AUGUST 13, 2014 Final changes in bold. 2012 SCOPE OF LANDLORDS WORK FOR LAB AND OFFICES ON FLOOR TWO Administrative Area ADDITIONAL PREMISES ONLY *** Space will be emptied of all furnishing prior to move-in date Partitions: Partitions for three new offices are to be added removed and relocated as indicated on the accompanying plans. Walls of Existing and new offices shall be insulated and extend to approximately 6” above the existing suspended ceiling. Existing office walls are comprised of gwb over steel studs and extend from floor to the underside of the suspended ceiling. The walls demising the Administrative areas from adjacent tenancies and R&D areas extend to the underside of the deck above and are constructed to have a one hour fire ratingabove. All new walls will be finished with two coats water based paint. The entire office space will have 2 new coats of water based paint to match bluebird’s existing space color scheme. Existing walls shall be patched “lavatory” room will have plumbing removed and repainted remain as necessary but maintain existing paint colorstorage room. A New storage room will have VCT removed and new partion will be constructed approximately 8’ from the existing main glass entry, extend 6” above the suspended ceiling, have three approximately 24”x24” clear glass vision panel insets and extend approximately 10’ from the existing demising wallmatching carpeting. Glass Panels: Where they exist, glass panels to remain. Glass panels from 4131 and 4130 will be removed to allow for the respective doors to be relocated. This is to allow for the modern-fold partition to be stored on the wall in between the doors when it is not separating 4131 and 4130. Entry: Existing glass entry to remain. Doors: Existing doors will be reused and relocated as necessary provided they have existing full lite glazing. All hardware are lever handles with brushed stainless finish. New office doors in offices 111, 112, & 113 will be solid oak to match building standardinstalled with full lite glazing where applicable. New All office doors will have full lite glazing. Office and conference room door hardware will consist be comprised of passage function latchsets with brushed stainless finish. Storage room latchsets will be comprised of class room function latchsets with brushed stainless finish. Floors: All carpeted areas in the administrative which are affected by construction will be protected re-carpeted with matching Xxxx Contract nylon loop carpet from “Turn Key Collection. 4” vinyl cove base has been installed at intersection of walls and reusedcarpet/vct. Vinyl tile installed in the floor of the kitchenette to remain. VCT will be removed from the storage area and be replaced with matching carpeting, 4” vinyl cove base will be installed at intersection of new walls and carpet/vct in new offices. VCT will be installed in an area adjacent to the new kitchenettestorage areas as well as areas affected by construction. Ceilings: All existing ceiling tiles will remain or be replaced as necessary. Any damaged ceiling tiles will be replaced with matching ceiling tiles. Any damage to ceiling grid will be repaired. Lighting: Existing All existing fluorescent lights will remain and be relocated and supplemented as necessary to accommodate the new configuration. All existing fluorescent lights will be inspected to insure proper functioning and be repaired or replaced as necessary.. BluebirdBio Final Scope of Work 8/13/2012

Integration of Documents; Supremacy. This First Amendment Second Lease Extension Agreement contains the full understanding and agreement between the parties. The parties hereto intend that this First Amendment Second Lease Extension Agreement operates to amend and modify the Existing Lease, and that those two documents shall be interpreted conjunctively; with any express conflict between the two to be resolved in favor of the stated terms of this First AmendmentSecond Lease Extension Agreement. Except as modified hereby, all other terms and conditions of the Existing Lease shall remain unchanged and enforceable in a manner consistent with this First Amendment, including Lessee’s right Second Lease Extension Agreement. Defined terms used in this Second Lease Extension Agreement that are not otherwise defined herein shall have the definitions ascribed to assignment and subletting of such terms in the Expansion Space as set forth thereinExisting Lease. This Agreement shall be governed by the laws of the Commonwealth of Massachusetts. Any provisions deemed unenforceable shall be severable, and the remainder of this First Second Lease Amendment Extension Agreement and the Existing Lease shall be enforceable in accordance with their terms. [Signature Pages Follow] Witness our hands and seals as of the date first written above. LESSOR RIVERTECH ASSOCIATES II, LLC By: Rivertech Associates II, Inc., its Manager By: /s/ Xxxxxx Xxxxxxx Name: Xxxxxx Xxxxxxx Title: President its duly authorized Manager LESSEE DIMENSION THERAPEUTICSBLUEBIRD BIO, INC. By: /s/ Xxxxxxxx Xxxx Xxxxxxx its duly authorized, Chief Executive Officer Nameauthorized President/Vice President By: Xxxxxxxx /s/ Xxxxxxx Title: CEO DIMENSION THERAPEUTICSX. Xxxxx its duly authorized Treasurer/Ass’t Treasurer BLUEBIRD BIO, INC. FIRST SECOND LEASE AMENDMENT EXTENSION AND MODIFICATION AGREEMENT EXHIBIT A DIMENSION THERAPEUTICSSee Attached BLUEBIRD BIO Floor Four 840 Memorial Drive Cambridge, INC. FIRST LEASE AMENDMENT EXHIBIT B DIMENSION THERAPEUTICS Floor Two 000 Xxxxxxxx Xxxxx XxxxxxxxxMA AUGUST 13, XX October 20, 2014 Final changes in bold. 2012 SCOPE OF LANDLORDS WORK FOR LAB AND OFFICES ON FLOOR TWO Administrative Area ADDITIONAL PREMISES ONLY *** Space will be emptied of all furnishing prior to move-in date Partitions: Partitions for three new offices are to be added removed and relocated as indicated on the accompanying plans. Walls of Existing and new offices shall be insulated and extend to approximately 6” above the existing suspended ceiling. Existing office walls are comprised of gwb over steel studs and extend from floor to the underside of the suspended ceiling. The walls demising the Administrative areas from adjacent tenancies and R&D areas extend to the underside of the deck above and are constructed to have a one hour fire ratingabove. All new walls will be finished with two coats water based paint. The entire office space will have 2 new coats of water based paint to match bluebird’s existing space color scheme. Existing walls shall be patched “lavatory” room will have plumbing removed and repainted remain as necessary but maintain existing paint colorstorage room. A New storage room will have VCT removed and new partion will be constructed approximately 8’ from the existing main glass entry, extend 6” above the suspended ceiling, have three approximately 24”x24” clear glass vision panel insets and extend approximately 10’ from the existing demising wallmatching carpeting. Glass Panels: Where they exist, glass panels to remain. Glass panels from 4131 and 4130 will be removed to allow for the respective doors to be relocated. This is to allow for the modern-fold partition to be stored on the wall in between the doors when it is not separating 4131 and 4130. Entry: Existing glass entry to remain. Doors: Existing doors will be reused and relocated as necessary provided they have existing full lite glazing. All hardware are lever handles with brushed stainless finish. New office doors in offices 111, 112, & 113 will be solid oak to match building standardinstalled with full lite glazing where applicable. New All office doors will have full lite glazing. Office and conference room door hardware will consist be comprised of passage function latchsets with brushed stainless finish. Storage room latchsets will be comprised of class room function latchsets with brushed stainless finish. Floors: All carpeted areas in the administrative which are affected by construction will be protected re-carpeted with matching Xxxx Contract nylon loop carpet from “Turn Key Collection. 4” vinyl cove base has been installed at intersection of walls and reusedcarpet/vct. Vinyl tile installed in the floor of the kitchenette to remain. VCT will be removed from the storage area and be replaced with matching carpeting, 4” vinyl cove base will be installed at intersection of new walls and carpet/vct in new offices. VCT will be installed in an area adjacent to the new kitchenettestorage areas as well as areas affected by construction. Ceilings: All existing ceiling tiles will remain or be replaced as necessary. Any damaged ceiling tiles will be replaced with matching ceiling tiles. Any damage to ceiling grid will be repaired. Lighting: Existing All existing fluorescent lights will remain and be relocated and supplemented as necessary to accommodate the new configuration. All existing fluorescent lights will be inspected to insure proper functioning and be repaired or replaced as necessary. HVAC: The base building HVAC distribution system will be inspected and adjusted as necessary to assure distribution, airflow, and proper operation of thermostats and variable air volume (VAV) boxes. There will be a redistribution of the system to accommodate 5 separate zones as indicated on the drawings. This work will be designed by landlord’s consulting engineer. The office area will be provided with make-up air from either the 30 ton roof mounted MUA unit or house systems in order to provide fresh air to the office and maintain positive pressure with respect to R&D space. A pre-construction balancing/CFM reading will be done to show existing air balance in the space. The landlord’s engineer will perform HVAC load calculations to take into account insulation, square footage, occupancy and equipment heat loss to determine heating and cooling loads. Expected equipment and occupant load shall be provided to the landlord’s engineer for this purpose. The space will be balanced according to these calculations. All balancing will be conducted by a XXXX certified balancing technician. Pre-construction balancing, engineering calculations and post-construction “as built” documentation/balancing reports will be provided to the tenant or the tenant’s designee. The new space will conform to ASHRAE Standard 55 “Thermal Environmental Conditions for Human Occupancy”. All HVAC equipment shall be inspect by the landlord and replaced as necessary. The lessee accepts the existing HVAC system provided that it is in good working order, that it conforms to ASHRAE Standard 55, and that a reasonable temperature is maintained in the office areas. In the event during the lease term the HVAC system does not meet the aforementioned prerequisites the landlord will provide a new system which will be replaced at the Landlord’s cost. The tenant will be responsible for maintaining and repairing all tenant specific supplemental mechanical equipment beyond the 6 month warranty period. Tenant specific mechanical equipment will be delivered in good operating condition. Kitchenette: The kitchenette will remain undisturbed. Electrical: Existing electrical outlets throughout the administration area and the office space in the R&D area in the form of existing and new 1l0v outlets to remain. All utilities servicing the tenant’s premises and equipment are separately metered and will be read monthly by the landlord for reimbursement by the tenant. New outlets will be installed to accommodate the new layout. Each office will have a minimum of 3 120/20a 5-20R receptacles. All electrical circuits will be labeled via labels at the outlet, junction box, safety switch, or other corresponding electrical equipment and a corresponding label on the electrical panel indicating the appropriate circuit breaker. Furnishings: No reception desk cubicles, work stations or furniture of any sort shall be provided by the landlord. Specialties: A demountable partition by Modernfold or equal will be installed as indicated in the plans. This wall will have a “Dry Erase” surface from floor to ceiling. BluebirdBio or their designee will have access to the space during the renovation to inspect progress and that the work being done conforms to this scope. Fire Protection: Fire protection will be added as needed and required by Massachusetts Building cod, NFPA and local Fire Code. Work included in this scope will comply with the Massachusetts Building Code and NFPA. BluebirdBio Final Scope of Work 8/13/2012 R&D AREA Demolition: Existing lab benches, plumbing, piping, vinyl tile, doors and walls required to be removed to accommodate new plan will be removed. The existing 6’ hood shall be capped and removed from the premises. The existing wing wall adjacent to the hood shall be removed per attached drawings. The entire R&D area will have 2 coats water based paint applied per Bluebird bio’s existing paint scheme New Partitions: New partitions enclosing new tissue culture suites shall consist of existing walls comprised of 5/8”gwb over 3 1/2” steel studs and extending from floor to 6” above the underside of the suspended ceiling. Walls and trim will be finished with two coats water based paint. Paint finish in tissue culture rooms to be semi gloss. The tissue culture rooms will be separated from the main laboratory by a hallway as indicated in the drawing. Existing glass panels in the exterior offices shall be removed. The walls surrounding the “radio-isotope room” shall extend to the underside of the deck above and have an additional layer of 5/8” gwb applied to each accessible side of the wall. Walls will be constructed to the deck above with 2 layers of 5/8” GWB. Walls will be completely sealed with appropriate sealant in order to prevent any contamination of adjoining spaces. Work will be consistent with attached drawing and keynotes. The existing exterior window in the office to become the darkroom shall be blacked out via either applied opaque vinyl or an opaque panel which will prevent any light from entering via the window. Doors: Where indicated on the drawings, Xxxxxx Ultra-Clean Series Atmospheric 110 doors with push plate activators and safety scan sensors will be installed. Buttons to activate the doors will be installed.

Integration of Documents; Supremacy. This First Amendment contains the full understanding and agreement between the parties. The parties hereto intend that this First Amendment operates to amend and modify the Existing Lease, and that those two documents shall be interpreted conjunctively; with any express conflict between the two to be resolved in favor of the stated terms of this First Amendment. Except as modified hereby, all other terms and conditions of the Existing Lease shall remain unchanged and enforceable in a manner consistent with this First Amendment, including Lessee’s right to assignment and subletting of the Expansion Space as set forth therein. This Agreement shall be governed by the laws of the Commonwealth of Massachusetts. Any provisions deemed unenforceable shall be severable, and the remainder of this First Lease Amendment and the Existing Lease shall be enforceable in accordance with their terms. [Signature Pages Follow] LESSOR RIVERTECH ASSOCIATES II, LLC By: Rivertech Associates II, Inc., its Manager By: /s/ Xxxxxx Xxxxxxx Name: Xxxxxx Xxxxxxx Title: President LESSEE DIMENSION THERAPEUTICS, INC. By: /s/ Xxxxxxxx Xxxxxxx its duly authorized, Chief Executive Officer Name: Xxxxxxxx Xxxxxxx Title: CEO DIMENSION THERAPEUTICS, INC. FIRST LEASE AMENDMENT EXHIBIT A DIMENSION THERAPEUTICS, INC. FIRST LEASE AMENDMENT EXHIBIT B DIMENSION THERAPEUTICS Floor Two 000 Xxxxxxxx Xxxxx Xxxxxxxxx, XX October 20, 2014 Final changes in bold. SCOPE OF LANDLORDS WORK FOR LAB AND OFFICES ON FLOOR TWO Administrative Area Partitions: Partitions for three new offices are to be added as indicated on the plans. Walls of new offices shall be insulated and extend to approximately 6” above the existing suspended ceiling. Existing office walls are comprised of gwb over steel studs and extend from floor to the underside of the suspended ceiling. The walls demising the Administrative areas from adjacent tenancies and R&D areas extend to the underside of the deck above and are constructed to have a one hour fire rating. All new walls will be finished with two coats water based paint. Existing walls shall be patched and repainted as necessary but maintain existing paint color. A new partion will be constructed approximately 8’ from the existing main glass entry, extend 6” above the suspended ceiling, have three approximately 24”x24” clear glass vision panel insets and extend approximately 10’ from the existing demising wall. Glass Panels: Where they exist, glass panels to remain. Entry: Existing glass entry to remain. Doors: All hardware are lever handles with brushed stainless finish. New doors in offices 111, 112, & 113 will be solid oak to match building standard. New office door hardware will consist of passage function latchsets with brushed stainless finish. Floors: All carpeted areas in the administrative which are affected by construction will be protected and reused. 4” vinyl cove base will be installed at intersection of new walls and carpet/vct in new offices. VCT will be installed in an area adjacent to the new kitchenette. Ceilings: All existing ceiling tiles will remain or be replaced as necessary. Any damaged ceiling tiles will be replaced with matching ceiling tiles. Any damage to ceiling grid will be repaired. Lighting: Existing fluorescent lights will remain and be relocated and supplemented as necessary to accommodate the new configuration. All existing fluorescent lights will be inspected to insure proper functioning and be repaired or replaced as necessary.

Integration of Documents; Supremacy. This First Amendment contains the full understanding and agreement between the parties. The parties hereto intend that this First Amendment operates Amended and Restated Lease Agreement incorporate the provisions of the original Lease (to amend the extent not specifically superseded by the terms and modify conditions hereof) and that conjunctively these documents constitute the Existing Leasefull and complete agreement as between the parties. The following provisions of the Original Lease are not applicable to the Extended Term: Section 1 (Term); Section 2 (to the extent of the Schedule of Annual Base Rent); Section 3 (as to the first through fourth paragraphs, only); Section 4 (as to the first, and second, and fourth paragraphs, only); Section 22 (solely to the extent that those two documents the notice addresses appearing on the execution pages hereof supersede); Section 33 (which is wholly superseded by Section 5 hereof); and Exhibit B (which is wholly superseded by Exhibit B as it is attached hereto). As a condition to the effectiveness of this Agreement, LESSOR shall be interpreted conjunctively; with any express conflict between provide to LESSEE either (a) the two written acknowledgement of the current mortgagee that the existing Subordination, Non-Disturbance and Attornment Agreement non-disturbance agreement remains in effect and applies to be resolved this Amended and Restated Lease Agreement or (b) a new Subordination, Non-Disturbance and Attornment Agreement in the form attached hereto in favor of LESSEE executed by the stated terms of current mortgagee with respect to this First Amendment. Except as modified hereby, all other terms Amended and conditions of the Existing Restated Lease shall remain unchanged and enforceable in a manner consistent with this First Amendment, including Lessee’s right to assignment and subletting of the Expansion Space as set forth thereinAgreement. This Agreement shall be governed by the laws of the Commonwealth of Massachusetts. Any provisions deemed unenforceable shall be severable, and the remainder of this First Lease Amendment and the Existing Lease Agreement shall be enforceable in accordance with their its terms. [Signature Pages Follow] LESSOR This Agreement may only be modified m writing, signed by both parties. Unless otherwise provided herein, all capitalized terms used herein shall have the same meaning as set forth in the Original Lease. Witness our hands and seals the first date above written. RIVERTECH ASSOCIATES II, LLC By: By Rivertech Associates IIAssociates, Inc., Inc. its duly authorized Manager By: /s/ Xxxxxx Xxxxxxx NameXxxxxx Xxxxxxx, President Notice Address: 000 Xxxxxxxx Xxxxxx Xxxxxxx Title0xx Xxxxx Xxxxxx, Xxxxxxxxxxxxx 00000 with a copy to: President LESSEE DIMENSION THERAPEUTICSXxxxxxxxxxx X. Xxxxxxx, Esq. Xxxxxxxxx Xxxxxxxxxx & Xxxx LLP Prudential Tower 000 Xxxxxxxx Xxxxxx Xxxxxx, Xxxxxxxxxxxxx 00000 GENET1X PHARMACEUTICALS, INC. By: /s/ Xxxxxxxx Xxxxxx X. Xxxxxxx its duly authorizedauthorized (Attached Secretary/Clerk’s Certificate As To Authority) Notice Address: 000 Xxxxxxxx Xxxxx 0xx Xxxxx Xxxxxxxxx, Chief Executive Officer NameXxxx. with a copy to: Xxxxxxxx Xxxxxxx Title: CEO DIMENSION THERAPEUTICSGENETIX PHARMACEUTICALS, INC. FIRST AMENDED AND RESTATED LEASE AMENDMENT EXHIBIT A DIMENSION THERAPEUTICS, INC. FIRST LEASE AMENDMENT AGREEMENT REVISED EXHIBIT B DIMENSION THERAPEUTICS Operating Expenses 2006 000 Xxxxxxxx Xxxxx—Riverside Technology Center DESCRIPTION PSF HEAT $ 0.54 BUILDING ELECTRIC $ 2.01 WATER & SEWER $ 0.21 ELEVATOR MAINTENANCE $ 0.15 PARKING/CAFE EXPENSE $ 0.26 RUBBISH REMOVAL $ 0.14 INSURANCE $ 0.36 GROUNDS CARE $ 0.27 LEGAL/ACCT/ADMIN $ 0.11 JANITORIAL SERVICES $ 0.50 GENERAL MAINTENANCE $ 1.38 HVAC MAINTENANCE $ 0.50 LIFE SAFETY SYSTEMS $ 0.11 MANAGEMENT $ 3.28 Total Operating Expenses $ 9.82 Real Estate Taxes (FY 2007) $ 4.63 Note: Actual numbers for 2007 and all subsequent years will vary based on actual costs and expenses incurred. THE ABBEY GROUP Genetix Pharmaceuticals Relocation to Floor Two Three, 000 Xxxxxxxx Xxxxx Xxxxxxxxx, XX October 20, 2014 Final changes in bold. SCOPE OF LANDLORDS WORK FOR LAB AND OFFICES ON FLOOR TWO Administrative Revised 5/1/2007 Scope of Work by Landlord Office Area Partitions: Partitions for three new offices are • All walls to be added repainted • Existing lights to be relamped as required • Space to be cleaned and prepared for occupancy • Existing benchtop in support area to be relocated to 3 perimeter offices which presently do not have benchtops. Laboratory Area Physical • Repaint all walls • Vinyl tile floor in main labs and in all non-office areas where seamless tile does not exist. • New seamless vinyl floor in BL-2A Lab, BL-2B Lab & autoclave/glasswashing room. • New ceiling and lights throughout lab area. • Provide existing laboratory cabinets with new bench tops as indicated on the plans. Walls of new offices shall be insulated and extend to approximately 6” above the existing suspended ceiling. Existing office walls are comprised of gwb over steel studs and extend from floor to the underside of the suspended ceiling. The walls demising the Administrative areas from adjacent tenancies and R&D areas extend to the underside of the deck above and are constructed to have a one hour fire rating. All new walls will be finished with two coats water based paint. Existing walls shall be patched and repainted as necessary but maintain existing paint color. A new partion will be constructed approximately 8’ from the existing main glass entry, extend 6” above the suspended ceiling, have three approximately 24”x24” clear glass vision panel insets and extend approximately 10’ from the existing demising wall. Glass Panels: Where they exist, glass panels to remain. Entry: Existing glass entry to remain. Doors: All hardware are lever handles with brushed stainless finish. New doors in offices 111, 112, & 113 will be solid oak to match building standard. New office door hardware will consist of passage function latchsets with brushed stainless finish. Floors: All carpeted areas in the administrative which are affected by construction will be protected “Floor Plan Exhibit”. • Provide 10 foot long single tier reagent shelving above three benchtops in “Biology Lab A” Mechanical • Assure proper operation of l0ton supplemental air conditioning supplying main Biology Labs A&B • Assure proper operation of air conditioning units, humidification and reuseddehumidification system in both BL-2 labs. 4” vinyl cove base will be installed at intersection • Assure proper operation of new walls cold room. • Assure proper operation of supplemental air conditioning in equipment room. • Provide adequate exhaust air for Tenant’s (three) six foot hoods, BL2 exhaust hood, BL2 Lab sinks, chemical storage room and carpet/vct in new offices. VCT will be installed in an area adjacent to the new kitchenette. Ceilings: All existing ceiling tiles will remain or be replaced as necessary. Any damaged ceiling tiles will be replaced with matching ceiling tiles. Any damage to ceiling grid will be repaired. Lighting: Existing fluorescent lights will remain and be relocated and supplemented as necessary to accommodate the new configuration. All existing fluorescent lights will be inspected to insure proper functioning and be repaired or replaced as necessaryautoclave.