Mutation frequencies Sample Clauses

Mutation frequencies. The first section of the MODEL PARAMETERS Web page (Figure 11) shows the current BRCA1, BRCA2, PALB2, ATM and CHEK2 mutation frequencies. The mutation frequency is defined as the proportion of all alleles in the population that is made of pathogenic mutations. It should not be confused with mutation carrier frequency which is a different quantity. For example, if p represents the mutation frequency in the population, the mutation carrier frequency is p2+2p(1-p). In this example, the BOADICA input should be "p". ► If you are uncertain how to specify mutation frequencies, please contact us for further clarification. To change these parameters, you can select one of the following options on the ‘Set mutation frequencies’ selection list:  UK  Ashkenazi  Iceland
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