Penicillins Sample Clauses

Penicillins. The water solutions of penicillins are not suitable for the radiation sterilization [52]. The reason is the radiolysis of water with the formation of free radical • OH inducing break-up of the β –lactam ring leading to the formation of benzylpenilloic and benzylpenicilloic acids [13.50]. The sensitivity of water solutions of different penicillins to radiolysis is different. For instance, ampicillin and amoxycillin undergo 90% decomposition on irradiation with 0.5 kGy, while cloxacillin needs irradiation at 5 kGy to decompose [13.38]. Some penicillins, for example, benzylopenicyllin or phenoxymethylpenicyllin acid, in the solid phase undergo small decomposition on irradiation (Fig.). On irradiation with high doses (700–800 kGy), penicillins can undergo radiolytic decomposition with the formation of simple gas products, such as CO and CO2 and, in small amounts, also H2 and CH4 [13.47] (Table 13.6). The irradiation effect on penicillins has also been studied by the ESR method. The results have confirmed the appearance of free radicals and permitted their structures to be proposed (Fig.).

Penicillins neomycin-polymyxin-hc otic susp 3.5 mg/ml-10000 unit/ml-1% 1

Penicillins cephalosporins and beta lactams may not be manufactured in the same building as the Product. The following chemicals and biologics require dedicated and self-contained manufacturing areas. Introduction of any of these materials into equipment used for the Product requires prior written consent. i. Dihydroergotamine ii. Tetracyclines, nitrofurantoin, streptomycin, vancomycin, chloramphenicol, neomycin, polymyxin B, and amphotericin B iii. All hormone products and derivatives iv. All pesticides, fungicides and rodenticides v. Blood products and vaccines. vi. All cytotoxic, embryotoxic and antineoplastic agents