Plasma Collection for Assessment of Blood Cytokines and Chemokines Sample Clauses

Plasma Collection for Assessment of Blood Cytokines and Chemokines. ‌ Blood will be collected and processed for plasma as specified in the Schedule of Events. Detailed instructions will be provided in the Study Laboratory Manual. The plasma aliquots will be placed immediately into a –70oC freezer for storage until shipment. All frozen specimens will be shipped to a central laboratory at the specified time frames detailed in the Study Laboratory Manual throughout the study. A panel of cytokines and chemokines assays will be performed on plasma to evaluate inflammatory biomarkers in CF (e.g.,(43;44)(45) Granulocyte Colony Stimulating Factor (GCSF), Interleukin-1ra (IL1ra), IL6, Interleukin-8 (IL8), TNF-α, Transforming Growth Factor- β1 (TGFβ1), Neutrophil elastase antiprotease complex (PMNeL), highly sensitive C-Reactive Protein (hsCRP), Calprotectin, Arginase-1, and Serum Amyloid A (SAA)). These assays will be performed at a central laboratory as specified in the Study Laboratory Manual.
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