Pleuritis Sample Clauses

Pleuritis convincing history of pleuritic pain or rub heard by a physician or evidence of pleural effusion, or (b) Pericarditis-documented by ECG or rub or evidence of pericardial effusion Renal disorder (a) Persistent proteinuria greater than 0.5 g/day or greater than 3 + if quantitation not performed, or (b) Cellular casts – may be red cell, hemoglobin, granular, tubular, or mixed Neurologic disorder (a) Seizures – in the absence of offending drugs or known metabolic derangements; e.g., uremia, ketoacidosis, or electrolyte imbalance, or (b) Psychosis – in the absence of offending drugs or known metabolic derangements, e.g., uremia, ketoacidosis or electrolyte imbalance Hematologic disorder (a) Hemolytic anemia – with reticulocytosis, or (b) Leukopenia – less than 4000/mm total on 2 or more occasions, or (c) Lymphopenia – less than 1500/mm on 2 or more occasions, or (d) Thrombocytopenia – less than 100,000/mm in the absence of offending drugs Immunologic disorder (a) Positive LE cell preparation, or (b) Anti-DNA – antibody to native DNA in abnormal titer, or (c) Anti- Sm – presence of antibody to Sm nuclear antigen, or (d) False positive serologic test for syphilis known to be positive for at least 6 months and confirmed by Treponema pallidum immobilization or fluorescent treponemal antibody absorption test Antinuclear antibody An abnormal titer of antinuclear antibody by immunofluorescence or an equivalent assay at any point in time and in the absence of drugs known to be associated with drug-induced lupus syndrome