Potential Impact. When dealing with potential impact, there are two complementary issues at stake:
Potential Impact. Biosensors market The global market for biosensors is forecast to reach US$12 billion by the year 2015. Growth in population and increase in number of people getting affected with various health issues such as diabetes and obesity is driving the need for periodic medical care, in turn propelling market growth of biosensors in medical diagnostics. Expanding medical applications, increase in R&D activities, and emergence of new technologies such as microfluidics, and non-invasive biosensing alternatives are the other market propellers. In addition, key factors driving growth for glucose biosensors include growing diabetic population, user-friendly designs, and increased point-of-care applications. Although glucose monitoring dominates the market because it is used in both point-of-care (POC) and home diagnostics applications, the demand for POC devices is increasing, and there is a need for a new technology to be developed to meet market needs in term of wider range of disease marker detection, multiple tests, better specificity and sensitivity and critically, the possibility to perform quantitation at low cost. In fact, the potential for the development of nanotechnology- enabled POC diagnostic devices is high. Their increasing availability and use could have significant patient benefits and cost-saving implications for health services. Some of the most important challenges for nanomedicine currently include: • Finding ways to translate advances in both technology and the understanding of the pathology of disease into preventive medicine; • Detecting disease at the earliest, most treatable stage; • Decreasing costs to healthcare services and increasing productivity at the same time; • Ensuring the cost of medical technologies is aligned with better patient prognosis; • Finding ways of improving on existing treatments and technologies. Potential impact of the project The sensor technology proposed in the BioEGOFET project can readily be adapted and indeed, would be ideal for these market requirements. The main goal of this research program is to produce a biosensor system that is more robust, reliable and user-friendly than current approaches and which will have a very wide range of applications due to the nature of the detection scheme, making new applications much quicker and cheaper to develop. It should be emphasized that the flexibility of the device proposed renders it suitable for isolated, individual, hand-held, portable use. On the other hand electr...
Potential Impact. Hypothetical Low Scores and Negative Publicity We discussed two additional areas o impact and potential impact: (1) What were the actual and potential e ects o negative publicity around a hospital’s scores? and (2) What would be the consequences i the hospital had a lower-than-average score published on the web site?
Potential Impact. This collection of views on the impact is derived from each of the work package leaders and reflects all experiences throughout the 5.5 years of collaborative work in the XXXX team. It was regarded as important to have all the original comments and views listed from each work package. Thus, repititions were warrented and the different wording of even similar topics was regarded as additional value. Scientific Management & Joint Data Analyis (WP1) The XXXX project had proven that an academic consortium is able to develop and perform a paediatric drug development program succesfully. The jointly analyised “XXXX” data might be used by one of the pharmaceutical companies identified for a PUMA submission (see WP14). With the approval of the enalapril Orodispersible Minitablets there is the potential to change the Standard of Care for Paediatric Patients with Heart Failure in Europe. Pharmaceutical Development (WP2) The XXXX consortium has developed a child-appropriate dosage form, orodispersible minitablets (ODMTs), with Enalapril maleate as the active substance at two different dose strengths (0.25 mg and 1.00 mg). The two products are stable, show good bioavailability of the active substance, are easy to prepare individualized doses and can be taken by children of all ages. So far, there is no product with this new dosage form on the global market. XXXX ODMTs are easy to use, patient- and parent-friendly and would close the gap for child-appropriate formulations of ACE inhibitors. Even small paediatric sub-populations would benefit from the ODMTs, as very small doses can be prepared as aqueous dispersions to administer directly into the mouth or via nasogastric tubes. Non-clinical safety (WP3) Enalapril is a relatively safe, untoxic substance. The excipients used in the ODMTs are safe for children of all ages, as being confirmed by the experts of the PDCO at the EMA. Clinical Trial Management, Pharmacovigilance and Safety (WP4) For the first time a publicly funded consortium was able to perform the complete set of clinical trials required to generate the PK, PD, and safety data set for demonstration of the suitability of ODMTs as a galenic formulation in paediatric patients with heart failure of all age groups requiring reliable and optimally dosed enalapril treatment. In the context of training of medical staff for clinical trials, a simulation-based training of study teams in study specific communication and pre analytical skills is an innovative approach t...
Potential Impact. Implementation of the Project modifications could result in levee disturbance that could affect drainage infrastructure and local surface runoff patterns. This potential impact is discussed in the Draft SEIR at page 3.1-5.
Potential Impact. Implementation of the Project modifications could affect groundwater or surface water quality resulting from contact with the water table. This potential impact is discussed in the Draft SEIR at page 3.2-4.
Potential Impact. Operation at the Xxxxxxx Bridge Erosion Repair site of barges and other in-water equipment originating from outside the project area could result in the introduction and spread of aquatic invasive species. This potential impact is discussed in the Draft SEIR at page 3.2-5.
Potential Impact. Implementation of the Project modifications could result in exceedance of the Federal General Conformity Thresholds during construction. This potential impact is discussed in the Draft SEIR at page 3.5- 12.
Potential Impact. Implementation of the Project modifications could result in the loss of wetlands and other waters of the United States. This potential impact is discussed in the Draft SEIR at page 3.8-7.
Potential Impact. Implementation of the Project modifications could result in the disturbance or removal of protected trees. This potential impact is discussed in the Draft SEIR at page 3.8-8.
