Production of GI-MAPS Sample Clauses

Production of GI-MAPS. With Toray Engineering Co., Ltd., BT codeveloped a micron size GI-MAPS producing machine with the aid of big grant from the government in which drug can be formulated as solid or semisolid state. BT has an alliance with Nipro Co., Ltd. to produce GI-MAPS under GMP condition. Nipro has a contract manufacturing function of GI-MAPS. With this machine, the applied area of GI-MAPS has been enlarged as follows; ・ Colon delivery of steroids etc. for the treatment of inflammatory bowel disease (IBD) where Eudragit S100 is used as the surface membrane. ・ Targeting of metronizadole and ampicillin to the stomach for the treatment of Helicobacter pylori infection where mucoadhesive polymer is used as the surface membrane. ・ Oral sustained-release preparation where water-insoluble semipermeable membrane like ethylcellulose or cellulose acetate membrane is used as the surface membrame. Capsule containing GI-MAPS GI-MAPS producing machine Patents Patents on GI-MAPS were obtained in USA and Japan. US patent; 7,097,851 B1, granted on August 29 in 2006 Japan Patent; 0000000, granted on April 23 in 2010 Japan Patent: 2017-125572 Dissolving micropiles To increase the skin permeability, many different approaches have been studied. For example, chemical/lipid absorption enhancers, iontophoresis and electroporation are under investigation. However, the success of these transdermal drug delivery systems has been limited because of low membrane permeability of drugs through the skin. On the other hand, based on the development of micro-fabrication technology, the use of micron-scale piles showed a dramatically increase of the skin permeability of drugs. Solid microneedles made of stainless steel have been shown to increase the transdermal permeability of drugs with “poke with patch”, “coat and poke” and “dip and scrape” delivery systems. BioSerenTach’s microneedle technology differs from those systems. Micropile is made of self-dissolving polymers having thread-forming property. The polymers are (1) proteins like albumin etc, (2) polysaccharides like dextran, chondroitin sulfate, hyaluronic acid etc, and (3) others. Strictly speaking, BioSerenTach’s microneedle is not a microneedle but is a micropile. Dissolving micropile can be easily prepared under room temperature. Therefore, this system, dissolving micropile, can be applied to drugs that are sensitive to high temperature such as peptide/protein drugs, i.e. insulin, erythropoietin, growth hormone etc. In addition, dissolving mi...
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