Progesterone hypothesis Sample Clauses

Progesterone hypothesis. As discussed above fibroids demonstrate increased mitotic activity in the luteal phase of the cycle and a similar effect is observed in women treated with oral progesterone (Segaloff et al. 1949; Xxxxxxxxx et al. 1985; Xxxxxxx 1985; Xxxxxxxxx et al. 1989). In contrast the anti- progesterone drug RU486 induced fibroid shrinkage after 3 months of use (Xxxxxx et al. 1993) while the administration of progesterone along with GnRH analogues reversed the shrinkage effect of the analogue (Xxxxxxxx et al. 1988; Xxxx et al. 1993). Fibroids in women receiving progesterone containing HRT also demonstrate increased mitotic activity as opposed to fibroids in women receiving oestrogen only HRT (Xxxxxxxx et al. 1992). Fibroids have higher progesterone receptor content than autologous myometrium and the fibroid progesterone receptor content correlates with fibroid growth (Xxxxxxx et al. 1993; Ichimura et al. 1998). The mechanism through which progesterone has its effect is unclear. It may be partly mediated by an increase in EGF as it has been demonstrated that fibroids have higher EGF content in the secretory phase of the cycle (Xxxxxxxx-Xxxxxxxx et al. 1994). Furthermore, the product of the Bcl – 2 protooncogene is much more abundant in fibroids in the secretory phase than the proliferative phase of the cycle while it is absent from normal myometrium (Matsuo et al. 1997). Evidence now supports a critical role for progesterone along with oestrogen in the growth of fibroids (Rein 2000).
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Related to Progesterone hypothesis

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