Rules for Stopping Treatment Sample Clauses

Rules for Stopping Treatment. Study agent infusion will be stopped earlier than the planned 24 hour course under the following circumstances: a drop in systolic BP of greater than 10 mm Hg or diastolic BP of greater than 5 mm Hg occurs associated with worsening of neurologic exam, not responsive to intravenous fluids or albumin; systolic blood pressure drops below 90 or diastolic below 55 without response to intravenous fluids or albumin; cardiac arrhythmia appears that may be related to or exacerbated by magnesium; urine output < 10 cc/hr unresponsive to intravenous fluids or diuretics; significant change in mental status (confusion, stupor, coma) accompanied by loss or diminution of reflexes thought to be due to magnesium toxicity; the patient’s attending physician believes for any reason that study agent infusion is producing an adverse effect that may negatively affect patient outcome.
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