Common use of Schedule of Changes Clause in Contracts

Schedule of Changes. Sponsor and Omnicare CR agree to the following changes and additional work pursuant to the general terms and conditions set forth in the Agreement: [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Reference Changes and/or Additions Estimated Service Fee (AS$) Pursuant to Exhibit D, Omnicare CR will provide clinical data management support for the Sponsor’s Cohort Study of PEP005 Topical Gel, Protocol # PEP005-002 Revised costing for tables and listings presented in Statistical Analysis Plan. The original proposal was costed at a discounted rate which will be maintained in this Change Order #1. The original estimate of Tables (**** repeat), Listings (**** repeat) and figures (**** repeat). Following on from design of data displays and reporting requirements there has been an increase in the number of Tables and Listings presented in the Statistical Analysis Plan. The updated count of Tables is **** repeat Listings is **** repeat and **** repeat Figures. Estimated Service Fees to be Invoiced * **** repeat tables @ $****/table = $**** **** * **** repeat listings@ $****/listing = $**** Services Fees not to be Invoiced * **** repeat figures @ $****/figure = $**** **** Actuals will be billed. * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project.

Schedule of Changes. Sponsor and Omnicare CR agree to the following changes and additional work pursuant to the general terms and conditions set forth in the Agreement: [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 24b-2 of the Securities Exchange Act of 19331934, as amended. Estimated Service Reference Changes and/or Additions Estimated Service Fee (AS$US$) Pursuant to Exhibit DI, Omnicare CR will provide clinical data management support additional statistical services for the Sponsor’s Cohort Study of PEP005 Topical Gel, Protocol # PEP005-002 Revised costing for tables and listings requirements Additional data displays presented in within the Data Monitoring Committee Statistical Analysis Plan. The original proposal was costed at a discounted rate which will be maintained in this Change Order #1. The original estimate of : • Data Tables (**** original contract included 10 unique and 5 repeat), Listings (**** repeat) ; actual displays were 17 unique and figures (**** repeat). Following on from design of data displays and reporting requirements there has been an increase in the number of Tables and Listings presented in the Statistical Analysis Plan. The updated count of Tables is **** 8 repeat Listings is **** repeat and **** repeat Figures. Estimated Service Fees to be Invoiced * **** repeat tables): - 7 unique tables @ $US$****/table = $US$**** - 3 repeat tables @ US$****/table US$**** * • Data Listings (original contract included 2 unique and 0 repeat; actual displays were 12 unique and 4 repeat listings): - 10 unique listings @ US$****/table US$**** - 4 repeat listings@ $listings @ US$****/listing = $/table US$**** Services Total Estimated Service Fees not to be Invoiced * US$***** repeat figures @ $Total Estimated Pass Through Expenses ****/figure = $** Total Estimated Budget US$**** **** Actuals will be billed. * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project.

Schedule of Changes. Sponsor and Omnicare CR agree to the following changes and additional work pursuant to the general terms and conditions set forth in the Agreement: [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] Reference Services to be Billed Estimated Additional Service Fee (AUS$) Pursuant to Exhibit B, Omnicare CR will provide Clinical Writing Services for the Sponsor’s Cohort Study of PEP005 Topical Gel, Protocol #PEP005-001, Version 2 More time will be required to draft the Clinical Study Report based on the increased number of tables and listings: • **** tables and **** listings were produced versus **** tables and **** listings originally contracted. • Estimated additional time: **** days of a Senior Writer @ $****/day = $**** **** day of a Director CW @ $****/day = $**** **** Total Estimated Additional Service Fees * **** Total Estimated Pass Through Expenses ****** Total Estimated Budget **** **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Reference Changes and/or Additions Estimated Service Fee (AS$) Pursuant to Exhibit D, Omnicare CR will provide clinical data management support for the Sponsor’s Cohort Study of PEP005 Topical Gel, Protocol # PEP005-002 Revised costing for tables and listings presented in Statistical Analysis Plan. The original proposal was costed at a discounted rate which will be maintained in this Change Order #1. The original estimate of Tables (**** repeat), Listings (**** repeat) and figures (**** repeat). Following on from design of data displays and reporting requirements there has been an increase in the number of Tables and Listings presented in the Statistical Analysis Plan. The updated count of Tables is **** repeat Listings is **** repeat and **** repeat Figures. Estimated Service Fees to be Invoiced * **** repeat tables @ $****/table = $**** **** * **** repeat listings@ $****/listing = $**** Services Fees not to be Invoiced * **** repeat figures @ $****/figure = $**** **** Actuals will be billed. * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project. In the event of any conflict between the provisions of this Change Order #4 and the Agreement, the terms of this Change Order #4 shall govern.

Schedule of Changes. Sponsor and Omnicare CR agree to the following changes and additional work pursuant to the general terms and conditions set forth in the Agreement: [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 24b-2 of the Securities Exchange Act of 19331934, as amended. Reference Changes and/or Additions Estimated Service Fee (AS$) Pursuant to Exhibit D, Omnicare CR will provide clinical data management support for the Sponsor’s Cohort Study of PEP005 Topical Gel, Protocol # PEP005-002 Revised costing for tables and listings presented in Statistical Analysis Plan. The original proposal was costed at a discounted rate which will be maintained in this Change Order #1. The original estimate of Tables (**** repeat), Listings (**** repeat) and figures (**** repeat). Following on from design of data displays and reporting requirements there has been an increase in the number of Tables and Listings presented in the Statistical Analysis Plan. The updated count of Tables is **** repeat Listings is **** repeat and **** repeat Figures. Estimated Service Fees to be Invoiced * **** repeat tables @ $****/table = $**** **** * **** repeat listings@ $****/listing = $**** Services Fees not to be Invoiced * **** repeat figures @ $****/figure = $**** **** Actuals will be billed. * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project.

Schedule of Changes. Sponsor and Omnicare CR agree to the following changes and additional work pursuant to the general terms and conditions set forth in the Agreement: [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 24b-2 of the Securities Exchange Act of 19331934, as amended. Reference Changes and/or Additions Estimated Service Fee (AS$AUS$) Pursuant to Exhibit DB, Omnicare CR will provide clinical data management Statistical and Clinical Writing support for the Sponsor’s Cohort Study of PEP005 Topical Gel, Protocol # PEP005-002 Revised costing for 001 Sponsor has requested the additional production of tables and listings presented in Statistical Analysis Plana graph as well as clinical writing additions. The original proposal was costed at a discounted rate which will be maintained in this Change Order #1. The original estimate of Tables (cost to produce the additional tables and graph are: * **** repeat), Listings (unique tables @ $****/table **** repeat) and figures (**** repeat). Following on from design of data displays and reporting requirements there has been an increase in the number of Tables and Listings presented in the Statistical Analysis Plan. The updated count of Tables is **** repeat Listings is **** repeat and **** repeat Figures. Estimated Service Fees to be Invoiced * **** repeat tables @ $****/table = $**** **** * **** repeat listings@ $****/listing = $**** Services Fees not to be Invoiced * **** repeat figures unique graph @ $****/figure = /graph **** The cost for the additional clinical writing are: * Senior Clinical Writer — ****days@ $****/day **** * Clinical Writing Director — **** day @ $****/day **** Total Estimated Service Fees **** * Total Estimated Pass Through Expenses **** ** Total Estimated Budget **** Actuals will be billed. * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project.

Schedule of Changes. Sponsor and Omnicare CR agree to the following changes and additional work pursuant to the general terms and conditions set forth in the Agreement: [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] Estimated Additional Service Reference Services to be Billed Fee (AUS$) Pursuant to Exhibit B, Omnicare CR will provide Clinical Writing Services for the Sponsor’s Cohort Study of PEP005 Topical Gel, Protocol #PEP005-001,Version 2 More time will be required to draft the Clinical Study Report based on the increased number of tables and listings: • **** tables and **** listings were produced versus **** tables and **** listings originally contracted. **** • Estimated additional time: **** days of a Senior Writer @ $****/day = $**** **** day day of a Director CW @ $****/day = $**** Total Estimated Additional Service Fees * **** Total Estimated Pass Through Expenses ****** Total Estimated Budget **** **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Reference Changes and/or Additions Estimated Service Fee (AS$) Pursuant to Exhibit D, Omnicare CR will provide clinical data management support for the Sponsor’s Cohort Study of PEP005 Topical Gel, Protocol # PEP005-002 Revised costing for tables and listings presented in Statistical Analysis Plan. The original proposal was costed at a discounted rate which will be maintained in this Change Order #1. The original estimate of Tables (**** repeat), Listings (**** repeat) and figures (**** repeat). Following on from design of data displays and reporting requirements there has been an increase in the number of Tables and Listings presented in the Statistical Analysis Plan. The updated count of Tables is **** repeat Listings is **** repeat and **** repeat Figures. Estimated Service Fees to be Invoiced * **** repeat tables @ $****/table = $**** **** * **** repeat listings@ $****/listing = $**** Services Fees not to be Invoiced * **** repeat figures @ $****/figure = $**** **** Actuals will be billed. * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project. In the event of any conflict between the provisions of this Change Order #4 and the Agreement, the terms of this Change Order #4 shall govern.

Schedule of Changes. Sponsor and Omnicare CR agree to the following changes and additional work pursuant to the general terms and conditions set forth in the Agreement: [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Estimated Service Reference Changes and/or Additions Estimated Service Fee (AS$AUS$) Pursuant to Exhibit DB, Omnicare CR will provide clinical data management Statistical and Clinical Writing support for the Sponsor’s Cohort Study of PEP005 Topical Gel, Protocol # PEP005-002 Revised costing for 001 Sponsor has requested the additional production of tables and listings presented in Statistical Analysis Plana graph as well as clinical writing additions. The original proposal was costed at a discounted rate which will be maintained in this Change Order #1. The original estimate of Tables (cost to produce the additional tables and graph are: * **** repeat), Listings (unique tables @ $****/table **** repeat) and figures (**** repeat). Following on from design of data displays and reporting requirements there has been an increase in the number of Tables and Listings presented in the Statistical Analysis Plan. The updated count of Tables is **** repeat Listings is **** repeat and **** repeat Figures. Estimated Service Fees to be Invoiced * **** repeat tables @ $****/table = $**** **** * **** repeat listings@ $****/listing = $**** Services Fees not to be Invoiced * **** repeat figures unique graph @ $****/figure = /graph **** The cost for the additional clinical writing are: * Senior Clinical Writer — ****days@ $****/day **** * Clinical Writing Director — **** day @ $****/day **** Total Estimated Service Fees **** * Total Estimated Pass Through Expenses **** ** Total Estimated Budget **** Actuals will be billed. * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project.

Schedule of Changes. Sponsor and Omnicare CR agree to the following changes and additional work pursuant to the general terms and conditions set forth in the Agreement: [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Reference Changes and/or Additions Estimated Service Fee (AS$US$) Pursuant to Exhibit DI, Omnicare CR will provide clinical data management support additional statistical services for the Sponsor’s Cohort Study of PEP005 Topical Gel, Protocol # PEP005-002 Revised costing for tables and listings requirements Additional data displays presented in within the Data Monitoring Committee Statistical Analysis Plan. The original proposal was costed at a discounted rate which will be maintained in this Change Order #1. The original estimate of : • Data Tables (**** original contract included 10 unique and 5 repeat), Listings (**** repeat) ; actual displays were 17 unique and figures (**** repeat). Following on from design of data displays and reporting requirements there has been an increase in the number of Tables and Listings presented in the Statistical Analysis Plan. The updated count of Tables is **** 8 repeat Listings is **** repeat and **** repeat Figures. Estimated Service Fees to be Invoiced * **** repeat tables): - 7 unique tables @ $US$****/table = $US$**** - 3 repeat tables @ US$****/table US$**** * • Data Listings (original contract included 2 unique and 0 repeat; actual displays were 12 unique and 4 repeat listings): - 10 unique listings @ US$****/table US$**** - 4 repeat listings@ $listings @ US$****/listing = $/table US$**** Services Total Estimated Service Fees not to be Invoiced * US$***** repeat figures @ $Total Estimated Pass Through Expenses ****/figure = $** Total Estimated Budget US$**** **** Actuals will be billed. * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project.

Schedule of Changes. Sponsor and Omnicare CR agree to the following changes and additional work pursuant to the general terms and conditions set forth in the Agreement: [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] Reference Services to be Billed Estimated Additional Service Fee (AUS$) Pursuant to Exhibit B, Omnicare CR will provide Clinical Writing Services for the Sponsor’s Cohort Study of PEP005 Topical Gel, Protocol #PEP005-001, Version 2 More time will be required to draft the Clinical Study Report based on the increased number of tables and listings: • **** tables and **** listings were produced versus **** tables and **** listings originally contracted. • Estimated additional time: **** days of a Senior Writer @ $****/day = $**** **** day of a Director CW @ $****/day = $**** **** Total Estimated Additional Service Fees * **** Total Estimated Pass Through Expenses ****** Total Estimated Budget **** **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 24b-2 of the Securities Exchange Act of 19331934, as amended. Reference Changes and/or Additions Estimated Service Fee (AS$) Pursuant to Exhibit D, Omnicare CR will provide clinical data management support for the Sponsor’s Cohort Study of PEP005 Topical Gel, Protocol # PEP005-002 Revised costing for tables and listings presented in Statistical Analysis Plan. The original proposal was costed at a discounted rate which will be maintained in this Change Order #1. The original estimate of Tables (**** repeat), Listings (**** repeat) and figures (**** repeat). Following on from design of data displays and reporting requirements there has been an increase in the number of Tables and Listings presented in the Statistical Analysis Plan. The updated count of Tables is **** repeat Listings is **** repeat and **** repeat Figures. Estimated Service Fees to be Invoiced * **** repeat tables @ $****/table = $**** **** * **** repeat listings@ $****/listing = $**** Services Fees not to be Invoiced * **** repeat figures @ $****/figure = $**** **** Actuals will be billed. * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project. In the event of any conflict between the provisions of this Change Order #4 and the Agreement, the terms of this Change Order #4 shall govern.

Schedule of Changes. Sponsor and Omnicare CR agree to the following changes and additional work pursuant to the general terms and conditions set forth in the Agreement: [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Estimated Service Reference Changes and/or Additions Estimated Service Fee (AS$US$) Pursuant to Exhibit DI, Omnicare CR will provide clinical data management support additional statistical services for the Sponsor’s Cohort Study of PEP005 Topical Gel, Protocol # PEP005-002 Revised costing for tables and listings requirements Additional data displays presented in within the Data Monitoring Committee Statistical Analysis Plan. The original proposal was costed at a discounted rate which will be maintained in this Change Order #1. The original estimate of : • Data Tables (**** original contract included 10 unique and 5 repeat), Listings (**** repeat) ; actual displays were 17 unique and figures (**** repeat). Following on from design of data displays and reporting requirements there has been an increase in the number of Tables and Listings presented in the Statistical Analysis Plan. The updated count of Tables is **** 8 repeat Listings is **** repeat and **** repeat Figures. Estimated Service Fees to be Invoiced * **** repeat tables): - 7 unique tables @ $US$****/table = $US$**** - 3 repeat tables @ US$****/table US$**** * • Data Listings (original contract included 2 unique and 0 repeat; actual displays were 12 unique and 4 repeat listings): - 10 unique listings @ US$****/table US$**** - 4 repeat listings@ $listings @ US$****/listing = $/table US$**** Services Total Estimated Service Fees not to be Invoiced * US$***** repeat figures @ $Total Estimated Pass Through Expenses ****/figure = $** Total Estimated Budget US$**** **** Actuals will be billed. * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project.

Schedule of Changes. Sponsor and Omnicare CR agree to the following changes and additional work pursuant to the general terms and conditions set forth in the Agreement: [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 24b-2 of the Securities Exchange Act of 19331934, as amended. Reference Changes and/or Additions Estimated Service Fee (AS$US$) Pursuant to Exhibit DI, Omnicare CR will provide clinical data management support additional statistical services for the Sponsor’s Cohort Study of PEP005 Topical Gel, Protocol # PEP005-002 Revised costing for tables and listings requirements Additional data displays presented in within the Data Monitoring Committee Statistical Analysis Plan. The original proposal was costed at a discounted rate which will be maintained in this Change Order #1. The original estimate of : • Data Tables (**** original contract included 10 unique and 5 repeat), Listings (**** repeat) ; actual displays were 17 unique and figures (**** repeat). Following on from design of data displays and reporting requirements there has been an increase in the number of Tables and Listings presented in the Statistical Analysis Plan. The updated count of Tables is **** 8 repeat Listings is **** repeat and **** repeat Figures. Estimated Service Fees to be Invoiced * **** repeat tables): - 7 unique tables @ $US$****/table = $US$**** - 3 repeat tables @ US$****/table US$**** * • Data Listings (original contract included 2 unique and 0 repeat; actual displays were 12 unique and 4 repeat listings): - 10 unique listings @ US$****/table US$**** - 4 repeat listings@ $listings @ US$****/listing = $/table US$**** Services Total Estimated Service Fees not to be Invoiced * US$***** repeat figures @ $Total Estimated Pass Through Expenses ****/figure = $** Total Estimated Budget US$**** **** Actuals will be billed. * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project.

Schedule of Changes. Sponsor and Omnicare CR agree to the following changes and additional work pursuant to the general terms and conditions set forth in the Agreement: [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Reference Changes and/or Additions Estimated Service Fee (AS$AUS$) Pursuant to Exhibit DB, Omnicare CR will provide clinical data management Statistical and Clinical Writing support for the Sponsor’s Cohort Study of PEP005 Topical Gel, Protocol # PEP005-002 Revised costing for 001 Sponsor has requested the additional production of tables and listings presented in Statistical Analysis Plana graph as well as clinical writing additions. The original proposal was costed at a discounted rate which will be maintained in this Change Order #1. The original estimate of Tables (cost to produce the additional tables and graph are: * **** repeat), Listings (unique tables @ $****/table **** repeat) and figures (**** repeat). Following on from design of data displays and reporting requirements there has been an increase in the number of Tables and Listings presented in the Statistical Analysis Plan. The updated count of Tables is **** repeat Listings is **** repeat and **** repeat Figures. Estimated Service Fees to be Invoiced * **** repeat tables @ $****/table = $**** **** * **** repeat listings@ $****/listing = $**** Services Fees not to be Invoiced * **** repeat figures unique graph @ $****/figure = /graph **** The cost for the additional clinical writing are: * Senior Clinical Writer — ****days@ $****/day **** * Clinical Writing Director — **** day @ $****/day **** Total Estimated Service Fees **** * Total Estimated Pass Through Expenses **** ** Total Estimated Budget **** Actuals will be billed. * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project.