Common use of Schedule of Changes Clause in Contracts

Schedule of Changes. Sponsor and Omnicare CR agree to the following changes and additional work pursuant to the general terms and conditions set forth in the Agreement: [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Pursuant to Exhibit D, Omnicare CR will provide clinical data management support for the Sponsor’s Cohort Study of PEP005 Topical Gel, Protocol # PEP005-002 Revised costing for tables and listings presented in Statistical Analysis Plan. The original proposal was costed at a discounted rate which will be maintained in this Change Order #1. The original estimate of Tables (**** repeat), Listings (**** repeat) and figures (**** repeat). Following on from design of data displays and reporting requirements there has been an increase in the number of Tables and Listings presented in the Statistical Analysis Plan. The updated count of Tables is **** repeat Listings is **** repeat and **** repeat Figures. * **** repeat tables @ $****/table = $**** **** * **** repeat listings@ $****/listing = $**** * **** repeat figures @ $****/figure = $**** **** Actuals will be billed. * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project.

Schedule of Changes. Sponsor and Omnicare CR agree to the following changes and additional work pursuant to the general terms and conditions set forth in the Agreement: [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 24b-2 of the Securities Exchange Act of 19331934, as amended. Pursuant to Exhibit DB, Omnicare CR will provide clinical data management Statistical and Clinical Writing support for the Sponsor’s Cohort Study of PEP005 Topical Gel, Protocol # PEP005-002 Revised costing for 001 Sponsor has requested the additional production of tables and listings presented in Statistical Analysis Plana graph as well as clinical writing additions. The original proposal was costed at a discounted rate which will be maintained in this Change Order #1. The original estimate of Tables (cost to produce the additional tables and graph are: * **** repeat), Listings (unique tables @ $****/table **** repeat) and figures (**** repeat). Following on from design of data displays and reporting requirements there has been an increase in the number of Tables and Listings presented in the Statistical Analysis Plan. The updated count of Tables is **** repeat Listings is **** repeat and **** repeat Figures. * **** repeat tables @ $****/table = $**** **** * **** repeat listings@ $****/listing = $**** * **** repeat figures unique graph @ $****/figure = /graph **** The cost for the additional clinical writing are: * Senior Clinical Writer — ****days@ $****/day **** * Clinical Writing Director — **** day @ $****/day **** Total Estimated Service Fees **** * Total Estimated Pass Through Expenses **** **** Actuals will be billed. * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project.

Schedule of Changes. Sponsor and Omnicare CR agree to the following changes and additional work pursuant to the general terms and conditions set forth in the Agreement: [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 24b-2 of the Securities Exchange Act of 19331934, as amended. Pursuant to Exhibit D, Omnicare CR will provide clinical data management support for the Sponsor’s Cohort Study of PEP005 Topical Gel, Protocol # PEP005-002 Revised costing for tables and listings presented in Statistical Analysis Plan. The original proposal was costed at a discounted rate which will be maintained in this Change Order #1. The original estimate of Tables (**** repeat), Listings (**** repeat) and figures (**** repeat). Following on from design of data displays and reporting requirements there has been an increase in the number of Tables and Listings presented in the Statistical Analysis Plan. The updated count of Tables is **** repeat Listings is **** repeat and **** repeat Figures. * **** repeat tables @ $****/table = $**** **** * **** repeat listings@ $****/listing = $**** * **** repeat figures @ $****/figure = $**** **** Actuals will be billed. * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project.

Schedule of Changes. Sponsor and Omnicare CR agree to the following changes and additional work pursuant to the general terms and conditions set forth in the Agreement: [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Pursuant to Exhibit DA, Omnicare CR will provide clinical data management additional services to support for the Sponsor’s Cohort Study of PEP005 Topical Gel, . Protocol # PEP005-002 Revised costing for tables 004. Version 3 Appendices to final Clinical Study report: • Set-up and listings presented in Statistical Analysis Plan. The original proposal was costed at a discounted rate which will be maintained in this Change Order #1. The original estimate of Tables (Management @ A$****/ project $ **** repeat), Listings (• Estimated Hyperlinks = **** repeat) and figures (units @ A$**** repeat). Following on from design of data displays and reporting requirements there has been an increase in the number of Tables and Listings presented in the Statistical Analysis Plan. The updated count of Tables is unit $ **** repeat Listings is • Estimated Scanned and Cleaned Pages units = **** repeat and units @ A$****/ unit $ **** repeat Figures. * • Estimated Volumes = **** repeat tables units @ $A$****/table / unit $ **** • Project Coordinator (Australia) = $**** hours @ A$****/hour $ **** Total Estimated Service Fees $ **** * Total Estimated Pass Through Expenses $ **** **** * Total Estimated Budget $ **** repeat listings@ $****/listing = $**** * **** repeat figures @ $****/figure = $**** **** Actuals will be billed. * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Pass Through Expenses incurred in support of the Project.

Schedule of Changes. Sponsor and Omnicare CR agree to the following changes and additional work pursuant to the general terms and conditions set forth in the Agreement: [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Pursuant to Exhibit DB, Omnicare CR will provide clinical data management Statistical and Clinical Writing support for the Sponsor’s Cohort Study of PEP005 Topical Gel, Protocol # PEP005-002 Revised costing for 001 Sponsor has requested the additional production of tables and listings presented in Statistical Analysis Plana graph as well as clinical writing additions. The original proposal was costed at a discounted rate which will be maintained in this Change Order #1. The original estimate of Tables (cost to produce the additional tables and graph are: * **** repeat), Listings (unique tables @ $****/table **** repeat) and figures (**** repeat). Following on from design of data displays and reporting requirements there has been an increase in the number of Tables and Listings presented in the Statistical Analysis Plan. The updated count of Tables is **** repeat Listings is **** repeat and **** repeat Figures. * **** repeat tables @ $****/table = $**** **** * **** repeat listings@ $****/listing = $**** * **** repeat figures unique graph @ $****/figure = /graph **** The cost for the additional clinical writing are: * Senior Clinical Writer — ****days@ $****/day **** * Clinical Writing Director — **** day @ $****/day **** Total Estimated Service Fees **** * Total Estimated Pass Through Expenses **** **** Actuals will be billed. * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project.