Common use of Schedule of Changes Clause in Contracts

Schedule of Changes. Sponsor and Omnicare CR agree to the following changes and additional work pursuant to the general terms and conditions set forth in the Agreement: [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Pursuant to Exhibit D, Omnicare CR will provide biometrics support for the Sponsor’s Cohort Study of PEP005 Topical Gel, Protocol # PEP005-003 In order of evaluate confounding study effects of **** (****) site, additional tables are to be produced and analysis performed at the request of the Sponsor, with **** (****) site excluded. This revision requires the following additional tables: **** **** x unique table @ A$****/table **** x repeat table @ A$****/table Biometrics Team Leader time. **** **** hours @ A$****/ hour Total Estimated Pass Through Expenses **** ** * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project.

Schedule of Changes. Sponsor and Omnicare CR agree to the following changes and additional work pursuant to the general terms and conditions set forth in the Agreement: [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Pursuant to Exhibit DB, Omnicare CR will provide biometrics Statistical and Clinical Writing support for the Sponsor’s Cohort Study of PEP005 Topical Gel, Protocol # PEP005-003 In order 001 Sponsor has requested the additional production of evaluate confounding study effects of **** (****) site, tables and a graph as well as clinical writing additions. The cost to produce the additional tables are to be produced and analysis performed at the request of the Sponsor, with **** (****) site excluded. This revision requires the following additional tablesgraph are: **** **** x unique table tables @ A$$****/table **** x * **** repeat table tables @ A$$****/table Biometrics Team Leader time. **** * **** hours unique graph @ A$$****/ hour Total Estimated Pass Through Expenses /graph **** The cost for the additional clinical writing are: * Senior Clinical Writer — ****days@ $****/day **** * Clinical Writing Director — **** day @ $****/day **** * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project.

Schedule of Changes. Sponsor and Omnicare CR agree to the following changes and additional work pursuant to the general terms and conditions set forth in the Agreement: [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 24b-2 of the Securities Exchange Act of 19331934, as amended. Pursuant to Exhibit D, Omnicare CR will provide biometrics support for the Sponsor’s Cohort Study of PEP005 Topical Gel, Protocol # PEP005-003 In order of evaluate confounding study effects of **** (****) site, additional tables are to be produced and analysis performed at the request of the Sponsor, with **** (****) site excluded. This revision requires the following additional tables: **** **** x unique table @ A$****/table **** x repeat table @ A$****/table Biometrics Team Leader time. **** **** hours @ A$****/ hour Total Estimated Pass Through Expenses **** ** * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project.

Schedule of Changes. Sponsor and Omnicare CR agree to the following changes and additional work pursuant to the general terms and conditions set forth in the Agreement: [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Pursuant to Exhibit DA, Omnicare CR will provide biometrics additional services to support for the Sponsor’s Cohort Study of PEP005 Topical Gel, . Protocol # PEP005-003 In order of evaluate confounding study effects of **** (****) site, additional tables are 004. Version 3 Appendices to be produced final Clinical Study report: • Set-up and analysis performed at the request of the Sponsor, with **** (****) site excluded. This revision requires the following additional tables: **** **** x unique table Management @ A$****/table / project $ **** x repeat table • Estimated Hyperlinks = **** units @ A$**** unit $ **** • Estimated Scanned and Cleaned Pages units = **** units @ A$****/table Biometrics Team Leader time. / unit $ **** • Estimated Volumes = **** units @ A$****/ unit $ **** • Project Coordinator (Australia) = **** hours @ A$****/ hour Total Estimated Pass Through Expenses /hour $ **** ** * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Pass Through Expenses incurred in support of the Project.