Structural Model. The bundle designability landscape showed a single maximum “hotspot” at (ΔZ, ΔΦ) = (21.5 Å, −33.8°) (Fig. 1C) corresponding to bundle placement in which each pair of helices was offset in both translation and rotation to accommo- date the gentle left-handed supertwist of the bundles (SI Ap- pendix, Fig.
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