Study participants. A set of participants of the Sant Pau Initiative on Neurodegeneration (SPIN cohort) was included in the study. The SPIN cohort is a multimodal research cohort for biomarker discovery and validation that includes participants with different neurodegenerative dementias, mild cognitive impairment and cognitively normal controls. All participants receive an extensive neurological and neuropsychological evaluation and undergo structural 3T brain MRI, blood extraction, and lumbar puncture for CSF biomarkers. A subset of participants also receives molecular imaging such as 18F- Fluorodeoxyglucose-PET, amyloid and/or Tau PET. More information on the SPIN cohort can be found at xxxxx://xxxxxxxxxxxxxxxxx.xxx/our-research/spin-cohort (Alcolea et al., in preparation). In this study, we included all 94 participants from the SPIN cohort recruited between November 2013 and September 2017 that had available CSF samples and 18F- Florbetapir PET imaging. Their clinical diagnoses were mild cognitive impairment (n=35), AD dementia (n=12), other dementias or neurodegenerative diseases (that included dementia with Lewy bodies [n=30], frontotemporal dementia [n=9], vascular dementia [n=1], and motor neuron disease [n=1]), and cognitively normal controls (n=6). All participants gave written consent, and the ethics committee of Hospital Sant Pau approved all procedures included in this study.
Appears in 6 contracts
Samples: Positive Percent Agreement, Positive Percent Agreement, Positive Percent Agreement
