Test animals. F o r p h a r m a co- k i n e t ics t es t i n g a n d de r m a l s t u dies, a d u l t m a le a n d fe m a le S p r a g u e–D a wle y r a t s, 7 t o 9 wee k s of a ge, s h a ll be u sed. F o r de r m a l s t u dies, y o un g a d u l t m i n i- pigs s h a ll a l so be u sed. T h e a n i m a l s s h o u ld be p ur c h a sed f r o m a r ep u t a ble de a le r a n d s h a ll be ide n t ified u po n a r - r iv a l a t t h e t es t i n g l a bo r a t o ry . T h e a n i m a l s s h a ll be selec t ed a t r a n do m fo r t h e t es t g r o u ps a n d a ny a n i m a l s h ow- i n g s ig n s of ill h e a l t h s h a ll n o t be u sed. I n a ll s t u dies, un less o t h e r wise speci- fied, e a c h t es t g r o u p s h a ll co n t a i n a t le a s t 4 a n i m a l s of e a c h sex fo r a t o t a l of a t le a s t 8 a n i m a l s.
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Samples: www.govinfo.gov, www.govinfo.gov
Test animals. F o r p h a r m a co- k i n e t ics t es t i n g a n d de r m a l s t u dies, a d Ad u l t m a le a n d fe fe- m a le S p r a g u e–D a wle y r a t s, s s h a ll be u sed fo r t es t i n g. T h e r a t s s h a ll be 7 t o 9 wee k s of old a ge, n d t h ei r weig h t r a n ge s h o u ld be co m p a ll be r a ble f r o m g r o u sed. F p t o g r de r m a l s t o u dies, y o un g a d u l t m i n i- pigs s h a ll a l so be u sed. p. T h e a n i m a l s s h o u ld a ll be p ur c h a sed f r o m a r ep u t a ble de a le r a n d s h a ll be pe r m a n e n t l y ide n t ified u po n a r - r rr iv a l a t t h e t es t i n g l a bo r a t o ry . T h e a n i m a l s s h a ll be selec se- lec t ed a t r a n do m fo r t h e t es t i n g g r o u ps ps, a n d a ny a n i m a l s h ow- i owi n g s ig n s of ill h e a l t h s h a ll n o t be u sed. I n a ll s t u dies, un less o t h e r wise speci- fied, e a c h t es t g r o u p s h a ll co n t a i n a t le a s t 4 a n i m a l s of e a c h sex fo r a t o t a l of a t le a s t 8 a n i m a l s..
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Samples: www.govinfo.gov, www.govinfo.gov