Gleason Score definition

Gleason Score means a system of grading prostate cancer tissue based on how it looks under a microscope. Gleason scores range from 2 to 10 and indicate how likely it is that a tumor will spread. A low Gleason Score means the cancer tissue is similar to normal prostate tissue and the tumor is less likely to spread. A high Gleason Score means the cancer tissue is very different from normal and the tumor is more likely to spread.
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Examples of Gleason Score in a sentence

  • A Contemporary Prostate Cancer Grading System: A Validated Alternative to the Gleason Score.

  • Wisman, Chris J.L.M. Meijer, Dani€elle A.M. Heideman, and Renske D.M. Steenbergen 3823 Gleason Score 7 Prostate Cancers Emerge through Branched Evolution of Clonal Gleason Pattern 3 and 4 Adam G.

  • Predicting Gleason Score of Prostate Cancer Patients Using Radiomic Analysis.

  • Targeted Biopsy to Detect Gleason Score Upgrading during Active Surveillance for Men with Low versus Intermediate Risk Prostate Cancer.

  • The cancer detection rates were compared before and after the changes of practice patterns.Results: The comparison of these two groups (limited versus extended biopsies) in terms of serum PSA levels, number of needle cores and jars per case, cancer detection rate, cancer ≤ 1mm, and Gleason Score ≥ 7, are shown in the following table.

  • Recently, its gene (TOP2A) has been described as the strongest predictor of outcome in a prognostic model for high Gleason Score (GS) prostate cancer (GS ≥ 7).

  • Distribution Of Gleason Score For The Physicians’ Health Study (1982-2003)PHS Prostate Cancer Randomly Selected Central Pathology Cohort (N=1,850) Cases (N=134) Review (N=134)Based on Pathology Review Central Review Gleason score N % N % N %2-435519.218*No separate reporting of 3+4 versus 4+3Conclusions: This study demonstrates that there appears to be a tendency to under grade prostate cancer.

  • When adjusting for Gleason Score, the CIR was 1.8 (P=0.2, 95%CI=0.6-5.3).Conclusions: These data demonstrate for the first time a significant association with TMPRSS2:ERG gene fusion lethal CaP and support the critical role of TMPRSS2:ERG gene fusion product as a putative oncogene in CaP.

  • Background: In part because pure Gleason Score 6 (GS6) prostate cancer at RP has no ability to metastasize to lymph nodes and because even without definitive therapy it is a relatively indolent disease, some experts have questioned whether GS6 cancer shouldbe renamed with a term that does not contain the word “cancer”.

  • To determine if the morphologic heterogeneity is linked to biologic differences, we performed a survey of candidate pathways implicated in PCa progression.Design: We created a tissue microarray from 16 radical prostatectomy specimens (RPS) (Gleason Score ≥7) comprising the following morphologic patterns: cribriform (10 RPS, 56 cores), fused glands (15 RPS, 94 cores), single cells/clusters/cords (10 RPS, 56 cores) and intraductal spread (IDS) (10 RPS, 45 cores).

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