Intention to treat definition

Intention to treat means a procedure in the conduct and analysis of randomized controlled trials. All patients allocated to a given arm of the treatment regimen are included in the analysis whether or not they received or completed the prescribed regimen. Failure to follow this step defeats the main purpose of random allocation and can invalidate the results.

Intention to treat means that the analysis is based on the initial intentions to provide tuition, rather than whether or not pupils actually received tuition. Our analysis was not done on an ‘intention to treat’ basis: if a pupil was intended to receive tuition, but for some reason did not, they would be excluded from our analysis.

Intention to treat means analysing all randomised patients for the most important outcome measures, and on the most important moments of effect measurement irrespective of non-compliance and co-interventions.

Examples of Intention to treat in a sentence

• Intention to treat (ITT) patient-survival of at least 5 years must be preferred to absolute survival for all end-stage liver disease (ESLD) patients, with or without HCC, because ITT analysis can capture the entire therapeutic process, including livertransplantation.

• The trial analysis will follow a fully detailed and approved Statistical Analysis Plan, a versioned controlled document written by the Trial Statisticians, signed by the Chief Investigator, and retained in the Statistics Trial Master File.11.1. Analysis Populations  Pragmatic Intention to treat (ITT) group - with all ineligible and protocol violator participants included in the analysis on an intention to treat basis with participants kept in their randomised treatment group.

• Two different analysis sets are defined: (Modified) Intention to treat setThis analysis set includes all subjects where the outcome can be calculated (more than two blood samples taken), even though the subject was not observed the full 18 weeks.

• Intention to treat analysis in clinical trials when there are missing data.

• Intention to treat outcome of T1 hepatocellular carcinoma with the “wait and not ablate” approach until meeting T2 criteria for liver transplant listing.

• Intention to treat analysis is done for RCTs. Poor: Any of the following fatal flaws exists: Groups assembled initially are not close to being comparable or maintained throughout the study; unreliable or invalid measurement instruments are used or not applied equally among groups (including not masking outcome assessment); and key confounders are given little or no attention.

• Intention to treat is the correct analysis for randomised trials.

• Intention to treat analysis is related to methodological quality [Letter].

• Table 6: Intention to treat estimates of dissemination workshops.

• Intention to treat population: Any subject included in the study, regardless of whether they received planned treatment.Protocol-compliant population: Any subject who was randomized and received the planned treatment.