Lanifibranor definition

Lanifibranor means an orally-available small molecule in development for the treatment of XXXX that acts to induce anti-fibrotic, anti-inflammatory and beneficial vascular and metabolic changes in the body by activating all three peroxisome proliferator-activated receptors, or PPAR, isoforms, and including any deuterated derivatives or analogs, racemates, salts, metabolites, esters, diastereomers, tautomers, enantiomers, prodrug forms, hydrates, solvates, intermediates, polymorphs and degradants thereof, in each case, that have a similar pharmacological effect, in crystal, powder or other form. PPARs are well-characterized nuclear receptor proteins that regulate gene expression, and their relevance for the fibrotic, inflammatory, vascular and metabolic processes that characterize XXXX is well-established.
Sample 1
Lanifibranor means Lanifibranor (IVA337), which, at the date of this Contract, is currently under a Phase 3 Study Evaluating Long-term Efficacy and Safety of Lanifibranor in Adult Patients with NXXX and Fibrosis 2 (F2)/Fibrosis 3 (F3) Stage of Liver Fibrosis (NATiV3) (CxxxxxxxXxxxxx.xxx Identifier: NCT04849728).
Sample 1
Lanifibranor means Lanifibranor (IVA337), which, at the date of this Contract, is currently under a Phase 3 Study Evaluating Long-term Efficacy and Safety of Lanifibranor in Adult Patients with NASH and Fibrosis 2 (F2)/Fibrosis 3 (F3) Stage of Liver Fibrosis (NATiV3) (ClinicalTrials.gov Identifier: NCT04849728).
Sample 1

Examples of Lanifibranor in a sentence

  • Leveraging its expertise and experience in the domain of compounds targeting nuclear receptors, transcription factors and epigenetic modulation, Inventiva is currently advancing two clinical candidates, as well as a deep pipeline of earlier stage programs: -Lanifibranor, its lead product candidate, is being developed for the treatment of patients with NASH, a common and progressive chronic liver disease for which there are currently no approved therapies.

  • The project finances the Borrower’s R&D expenses over the next 3 year, mainly related to the development of Lanifibranor, Odiparcil and YaP-Tead programs, as well as programs still at pre-clinical stages and potential new leads (non-clinical and clinical studies, product manufacturing, related regulatory expenses, and related G&A expenses).

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