Proof of Principle definition

Proof of Principle means that a Candidate Selection Compound has met the PoP Criteria as determined by the JSC pursuant to Section 3.5.
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Proof of Principle means: [***]
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Proof of Principle means that ATLAS Screening is deemed successful with respect to the Initial Target Proteins because either: [***]
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Examples of Proof of Principle in a sentence

  • The Initial Development Period will terminate pursuant to this section if Committee Action determines that, due solely to technical reasons of the pharmaceutical sciences growing from results obtained in the course of the Proof of Principle Studies, that it will not be practicable to develop any Initial Designated Product.

  • During such ****** period, the parties will conduct the Proof of Principle Studies, and during the *************** of such period, Endo shall conduct the Patent Review (and PPG shall cooperate reasonably therewith).

  • Progress will be measured by the degree by which new results obtained through international collaboration are used to improve the understanding of stellarator confinement, stability, sustainment, and divertor physics and the resolution of key scientific issues and the beginning of construction of a Proof of Principle compact stellarator experiment in the United States.

  • Finally, this project will develop a scenario methodology and apply it in a small Proof of Principle use case in Nigeria by conducting factor analysis of survey data and will use Generalized Linear Models (GLMs) in order to predict future issue stance scores and observed attitudes and behaviors of the population that will directly support TRAC’s Irregular Warfare Tactical Wargame (IW TWG).

  • The proposed Project must have already achieved at least Proof of Principle.

  • Proof of Principle: Decreased selectivity toward mitochondrial versus cytoplasmic ribosome confers decreased toxicity of compounds disclosed and/or claimed in the TRDF Patent Rights (“Disclosed Compounds”).

  • HQMC (LPD) Topics Discussed: • Transportation Management System (TMS) Update:o United States Transportation Command (USTRANSCOM) conducted a two-year Proof of Principle (PoP) on TMS.

  • Other than the costs of the Proof of Principle Studies or the Patent Review, and the incidental costs of the Project Contacts associated with the development of such a project plan, neither party will devote substantial resources or make substantial expenditures in connection with the Initial Development Period prior to the approval of such project plan by Committee Action.

  • Thyroxine plus Low-Dose, Slow-Release Triiodothyronine Replacement in Hypothyroidism: Proof of Principle.

  • All documents related to notices issued to other contractors awarded contracts under the Solicitation requesting contractors to conduct a Proof of Principle.


More Definitions of Proof of Principle

Proof of Principle means that a therapeutically relevant ***** is demonstrated for a Small Molecule or Large Molecule at a dose that can be reasonably translated to a therapeutic dose in man and which does not cause any serious toxic effects in the chosen animal model.
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Related to Proof of Principle

  • Point of Privilege means a matter that a member considers to question their integrity and/or the integrity of the Council.

  • Proof of Interest means a proof of Interest filed in any of the Debtors in the Chapter 11 Cases.

  • Statement of Preferences means the Issuer's Statement of Preferences of Variable Rate Demand Preferred Shares, dated as of March 31, 2021, as amended from time to time in accordance with the provisions thereof.

  • Nonpayment of premium means the failure or inability of the named insured to discharge any obligation in connection with the payment of premiums on a policy of insurance subject to this section, whether such payments are payable directly to the insurer or its agent or indirectly payable under a premium finance plan or extension of credit;

  • Proof of age The Company may require evidence of Age of any Annuitant or Owner.

  • Fourth Allocation of Principal means, with respect to any Payment Date, an amount equal to (1) the excess, if any, of (a) the sum of the Class A Note Balance, the Class B Note Balance, the Class C Note Balance and the Class D Note Balance as of such Payment Date (before giving effect to any principal payments made on the Notes on such Payment Date) over (b) the Pool Balance as of the end of the related Collection Period minus (2) the sum of the First Allocation of Principal, the Second Allocation of Principal and the Third Allocation of Principal for such Payment Date; provided, however, that the Fourth Allocation of Principal on and after the Final Scheduled Payment Date for the Class D Notes shall not be less than the amount that is necessary to reduce the outstanding principal amount of the Class D Notes to zero (after the application of the First Allocation of Principal, the Second Allocation of Principal and the Third Allocation of Principal).

  • Proof of vaccination means documentation provided by a tribal, federal, state or local government, or a health care provider, that includes an individual’s name, date of birth, type of COVID-19 vaccination given, date or dates given, depending on whether it is a one-dose or two-dose vaccine, and the name/location of the health care provider or site where the vaccine was administered. Documentation may include but is not limited to a COVID-19 vaccination record card or a copy or digital picture of the vaccination record card, or a print-out from the Oregon Health Authority’s immunization registry.

  • Regular Allocation of Principal means, with respect to any Payment Date, an amount not less than zero equal to (1) the excess, if any, of (a) the Note Balance of the Notes as of such Payment Date (before giving effect to any principal payments made on the Notes on such Payment Date) over (b) (i) the Pool Balance as of the end of the related Collection Period less (ii) the Targeted Overcollateralization Amount minus (2) the sum of the First Allocation of Principal, the Second Allocation of Principal, the Third Allocation of Principal, the Fourth Allocation of Principal and the Fifth Allocation of Principal for such Payment Date.

  • Third Allocation of Principal means, with respect to any Payment Date, an amount equal to (1) the excess, if any, of (a) the sum of the Class A Note Balance, the Class B Note Balance and the Class C Note Balance as of such Payment Date (before giving effect to any principal payments made on the Class A Notes, the Class B Notes and the Class C Notes on such Payment Date) over (b) the Pool Balance as of the end of the related Collection Period minus (2) the sum of the First Allocation of Principal and the Second Allocation of Principal for such Payment Date; provided, however, that the Third Allocation of Principal on and after the Final Scheduled Payment Date for the Class C Notes shall not be less than the amount that is necessary to reduce the outstanding principal amount of the Class C Notes to zero (after the application of the First Allocation of Principal and the Second Allocation of Principal).

  • Second Allocation of Principal means, with respect to any Payment Date, an amount equal to (1) the excess, if any, of (a) the sum of the Class A Note Balance and the Class B Note Balance as of such Payment Date (before giving effect to any principal payments made on the Class A Notes and the Class B Notes on such Payment Date) over (b) the Pool Balance as of the end of the related Collection Period minus (2) the First Allocation of Principal for such Payment Date; provided, however, that the Second Allocation of Principal on and after the Final Scheduled Payment Date for the Class B Notes shall not be less than the amount that is necessary to reduce the outstanding principal amount of the Class B Notes to zero (after the application of the First Allocation of Principal).

  • First Allocation of Principal means, with respect to any Payment Date, an amount equal to the excess, if any, of (a) the Class A Note Balance as of such Payment Date (before giving effect to any principal payments made on the Class A Notes on such Payment Date) over (b) the Pool Balance as of the end of the related Collection Period; provided, however, that the First Allocation of Principal for any Payment Date on and after the Final Scheduled Payment Date for any Class of Class A Notes shall not be less than the amount that is necessary to reduce the Note Balance of that Class of Class A Notes to zero.

  • Proof of Purchase means an original tax invoice clearly confirming a Purchase. The Proof of Purchase must clearly specify:

  • Financing Statement means a record or records composed of an initial financing statement and any filed record relating to the initial financing statement.

  • Proof of Disability means documented clinical findings that prove that You are Disabled.

  • Proof of payment means, as applicable, a copy of the check, confirmation of credit card or debit card payment, or confirmation of wire or automated clearinghouse transfer, and any other information required to demonstrate that payment has been made according to the EPA requirements, in the amount due, and identified with the appropriate docket number and Respondent’s name.

  • Proof of Concept has the meaning set forth in Section 2.3.

  • Payments of Principal and Interest Payments of Principal and Interest. Promptly after each Regular Record Date, the Trustee will deliver to the Company and DTC a written notice specifying by CUSIP number the amount of interest, if any, to be paid on each Global Note on the following Interest Payment Date (other than an Interest Payment Date coinciding with a Maturity Date) and the total of such amounts. DTC will confirm the amount payable on each Global Note on such Interest Payment Date by reference to the daily bond reports published by Standard & Poor's. On such Interest Payment Date, the Company will pay to the Trustee, and the Trustee in turn will pay to DTC, such total amount of interest due (other than on the Maturity Date), at the times and in the manner set forth below under "Manner of Payment". If any Interest Payment Date for any Note is not a Business Day, the payment due on such day shall be made on the next succeeding Business Day and no interest shall accrue on such payment for the period from and after such Interest Payment Date.

  • Proof of Claim means a proof of Claim Filed against any of the Debtors in the Chapter 11 Cases.

  • Proof of Loss means satisfactory written proof that a loss occurred for which the Group Policy provides benefits, which is not subject to any exclusion, and which meets all other conditions for benefits. Proof of Loss includes any other information We may reasonably require in support of a claim for benefits under the Group Policy.

  • Out-of-home care means placement in a foster family home or

  • AUTHORIZING SIGNATURE FOR THE CONTRACTOR X: . Date: . (Signature and Date Must Be Captured At Time of Signature) Print Name: . Print Title: . AUTHORIZING SIGNATURE FOR THE COMMONWEALTH: X: . Date: . (Signature and Date Must Be Captured At Time of Signature) Print Nxxx: Xxxx Xxxxxx . Print Title: Assistant Secretary for MassHealth . (Updated 7/22/2021) Page 1 of 1

  • Interest Rate Protection Agreement means any interest rate swap agreement, interest rate cap agreement, interest collar agreement, interest rate hedging agreement or other similar agreement or arrangement.

  • Interest Rate Protection Agreements means any agreement providing for an interest rate swap, cap or collar, or any other financial agreement designed to protect against fluctuations in interest rates.

  • Early identification and assessment of disabilities in children means the implementation of a formal plan for identifying a disability as early as possible in a child's life.

  • List of Holders has the meaning specified in Section 2.2(a).

  • In this award, unless the contrary intention appears:Act means the Fair Work Act 2009 (Cth)[Definition of adult apprentice inserted by PR544268 ppc 01Jan14] adult apprentice means an apprentice who is 21 years of age or over at the commencement of their apprenticeshipagreement-based transitional instrument has the meaning in the Fair Work (Transitional Provisions and Consequential Amendments) Act 2009 (Cth)award-based transitional instrument has the meaning in the Fair Work (Transitional Provisions and Consequential Amendments) Act 2009 (Cth)[Definition of default fund employee inserted by PR546097 ppc 01Jan14] default fund employee means an employee who has no chosen fund within the meaning of the Superannuation Guarantee (Administration) Act 1992 (Cth)[Definition of defined benefit member inserted by PR546097 ppc 01Jan14] defined benefit member has the meaning given by the Superannuation Guarantee (Administration) Act 1992 (Cth)[Definition of Division 2B State award inserted by PR503694 ppc 01Jan11] Division 2B State award has the meaning in Schedule 3A of the Fair Work (Transitional Provisions and Consequential Amendments) Act 2009 (Cth)[Definition of Division 2B State employment agreement inserted by PR503694 ppc 01Jan11] Division 2B State employment agreement has the meaning in Schedule 3A of theFair Work (Transitional Provisions and Consequential Amendments) Act 2009 (Cth)[Definition of employee substituted by PR997772 from 01Jan10] employee means national system employee within the meaning of the Act [Definition of employer substituted by PR997772 from 01Jan10] employer means national system employer within the meaning of the Actenterprise award-based instrument has the meaning in the Fair Work (Transitional Provisions and Consequential Amendments) Act 2009 (Cth)NES means the National Employment Standards as contained in sections 59 to 131 of the Fair Work Act 2009 (Cth)on-hire means the on-hire of an employee by their employer to a client, where such employee works under the general guidance and instruction of the client or a representative of the clientstandard rate means the minimum weekly wage for Level 3 in clause 14—Minimum wagestransitional minimum wage instrument has the meaning in the Fair Work (Transitional Provisions and Consequential Amendments) Act 2009 (Cth)