Proof of Principle definition

Proof of Principle means: [***]
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Proof of Principle means that a Candidate Selection Compound has met the PoP Criteria as determined by the JSC pursuant to Section 3.5.
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Proof of Principle means that ATLAS Screening is deemed successful with respect to the Initial Target Proteins because either: [***]
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Examples of Proof of Principle in a sentence

  • Dicerna shall also be responsible for the cost of all activities through Proof of Principle for the initial Non-Hepatocyte Neurodegeneration/Pain Targets.

  • Such payment shall not be due for any such Products Directed To a Selected Target after the first Product Directed To that Selected Target achieves Proof of Principle nor, for avoidance of doubt, will it be due for any Selected Target that becomes a Discontinued Target prior to the payment of such amounts.


More Definitions of Proof of Principle

Proof of Principle means that a therapeutically relevant ***** is demonstrated for a Small Molecule or Large Molecule at a dose that can be reasonably translated to a therapeutic dose in man and which does not cause any serious toxic effects in the chosen animal model.
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Proof of Principle means that a therapeutically relevant ***** is demonstrated for a Small Molecule or Large Molecule at a dose that can be reasonably translated to a therapeutic dose in man and which does not cause any serious toxic effects in the chosen animal model.
Sample 1

Related to Proof of Principle

  • Order of Priority means the order of priority of payments specified in paragraph 2.2 (Pre and Post Enforcement Waterfalls) of Annex 1.

  • Point of Privilege means a matter that a member considers to question their integrity and/or the integrity of the Council.

  • Statement of Preferences means the Issuer's Statement of Preferences of Variable Rate Demand Preferred Shares, dated as of March 31, 2021, as amended from time to time in accordance with the provisions thereof.

  • Nonpayment of premium means the failure or inability of the named insured to discharge any obligation in connection with the payment of premiums on a policy of insurance subject to this section, whether such payments are payable directly to the insurer or its agent or indirectly payable under a premium finance plan or extension of credit;

  • Place of primary use means the street address representative of where the customer's use of the telecommunications service primarily occurs, which must be the residential street address or the primary business street address of the customer. For mobile wireless services, place of primary use must be within the licensed service area of the home service provider.

  • Financing Statement means a record or records composed of an initial financing statement and any filed record relating to the initial financing statement.

  • Post-Enforcement Priority of Payments means the order of priority pursuant to which the Guarantor Available Funds shall be applied on each Guarantor Payment Date, following the delivery of a Guarantor Default Notice, in accordance with the Intercreditor Agreement.

  • MI 61-101 means Multilateral Instrument 61-101 – Protection of Minority Security Holders in Special Transactions;

  • Out-of-home care means placement in a foster family home or

  • Interest Rate Protection Agreement means any interest rate swap agreement, interest rate cap agreement, interest collar agreement, interest rate hedging agreement or other similar agreement or arrangement.

  • Burden of proof means a duty to establish a fact by a preponderance of the evidence, or evidence more convincing, by even the smallest degree, than the evidence presented by the other party. Se-Ling Hosiery v. Margulies, 364 Pa. 54, 70 A.2d 854 (1950).

  • Filing Statement means all UCC financing statements or other similar financing statements and UCC (Form UCC-3) termination statements required pursuant to the Loan Documents.

  • Financing Statements The meaning specified in Section 9-102(a)(39) of the UCC.