Specifically Binds definition

Specifically Binds means, in the case of a SMIP or other protein, the binding of such SMIP or other protein to a Target (or a portion thereof) above the level of background binding and wherein such SMIP or other protein is designed or being developed to exert its biological effect through binding to such Target (or such portion thereof).
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Specifically Binds means binding with a dissociation constant (Kd) of at least 10-6M.
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Specifically Binds means [***].
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Examples of Specifically Binds in a sentence

  • LmPC Specifically Binds and Is Inhibited by c-di-AMP.‌(A) Binding titration of c-di-AMP and LmPC using32P-c-di-AMP.(B) Enzymatic activity of LmPC in the presence of Acetyl-CoA (100 mM), varied pyruvate, and c-di- AMP concentrations as indicated.(C) Rate constants of pyruvate turnover in the presence of c-di-AMP.(D) Enzymatic activity of LmPC in the presence of pyruvate (20 mM), varied Acetyl-CoA (allosteric activator) and c-di-AMP concentrations as indi- cated.

  • RESULTS KRP2 Specifically Binds and Inhibits CDKA;1 and Not CDKB1;1Previously, the interaction of KRP proteins with the archetypical A-type CDKA;1 but not with the B-type CDKB1;1 has been dem- onstrated by yeast two-hybrid analysis (Lui et al., 2000; De Veylder et al., 2001; Zhou et al., 2002).

  • Alba, A.E.M.d., et al., VIRUS-CELL INTERACTIONS-A Bromodomain-Containing Protein from Tomato Specifically Binds Potato Spindle Tuber Viroid RNA In Vitro and In Vivo.

  • Heh2 Specifically Binds Snf7To evaluate the interactions between Heh1/2 and Snf7 biochem- ically, we affinity purified Heh1/2-GFP from whole cell extracts of wild-type (WT) cells using conditions that maintain interactions between the Heh proteins and Pom152 and Nup170 (Yewdell et al., 2011); we could not detect Snf7 bound to either Heh1- or Heh2-GFP (Figure 3A).

  • Ectopic Expression of HY5 Reduces the Abundance of BZR1 and HY5 Specifically Binds to the Dephosphorylated Form of BZR1Based on the findings that light affects the phosphorylation status and abundance of BZR1 and that HY5 interacts with BZR1 in vivo, we next examined whether an alteration in HY5 protein abun- dance affects BZR1 accumulation in plants.

  • RESULTS The SHARPIN UBL Domain Specifically Binds to the UBA Domain of HOIP ~ ~ To clarify the interaction mechanism between HOIP and SHARPIN, we first used the GFP-tagged SHARPIN UBL domain (residues 206–309) (hereafter referred to as SHARPINUBL) to map its binding region in HOIP by co-immunoprecipitation (coIP) assay.

  • The school shall provide an instructional program in chemical abuse and the prevention of chemical dependency.

  • ELAV Directly and Specifically Binds to Neuronal APA TargetsNext, we assessed whether ELAV exerts its function through direct binding to the functional targets identified above.

  • References herein to any ADC “directed to” or “with respect to” a particular Target mean that such ADC comprises an Antibody that Specifically Binds such Target.

  • HgII Ion Specifically Binds with T:T Mismatched Base Pair in Duplex DNA.


More Definitions of Specifically Binds

Specifically Binds refers to those antibodies that have a minimum affinity (KD value) of [******] (as measured by standard techniques such as the BIAcore) toward a specified antigen and do not bind to related isozymes, proteins or antigens with an affinity of better than 1 uM. Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential Investment under Rule 24b-2 under the Securities Exchange Act of 1934.
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Specifically Binds means binding with a dissociation constant (Kd) of at least [**].
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