Topical use definition

Topical use means application of a poison for the purpose of producing a localised effect on the surface of the organ or within the tissue to which it is applied.

Topical use means application to an external area of the body and affecting mostly the area to which it is applied, including intradermal and subcutaneous injection designed to locally treat such external area, including but not limited to the skin, ear and accessible mucous membranes including but not limited to those of the mouth, vagina and anus. TOPICAL USE shall comprise of drug formulations and delivery mechanisms including but not limited to lotions, creams, ointments, gels, powders (talc), patches, nanoparticles, microneedles and solutions (liquids) but shall exclude systemic uses, such as ingested or injected formulations of drugs. For the purpose of this agreement, TOPICAL USE shall specifically exclude OCULAR USE.

Topical use means a drug delivery method that does not involve ingesting or inhaling and includes application by means of a topical patch, a lotion, a gel, alcohol or a bath.

Examples of Topical use in a sentence

• The I/F TD will contain two multiplexer/demultiplexers, a pulse code modulator master unit, a payload interrogator, a payload data interleaver, and a payload signal processor.

• Topical use of the SRA was evaluated in a recent UCPRC research study (25).

• Topical use of cotton swabs with antibiotics and with hypertonic sodium chloride solution is prescribed.Osteoperiostitis (periostitis) is an inflammation of the periosteum and bone formations of the orbit.

• Topical use of (chamomile) oil can decrease the frequency of nocturia in children with monosymptomatic nocturnal or daytime enuresis.

• Topical use of 15% L-ascorbic acid combined with 1% alpha-tocopherol has been shown to provide more significant protection against sunburn skin cell formation compared to L-ascorbic acid or 1% alpha-tocopherol alone.

• Topical use of human recombinant epidermal growth factor (h‐EGF) in venous ulcers.

• Topical use of adrenaline in different concentrations for endoscopic sinus surgery.

• Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study.

• Topical use of coenzyme Q10-loaded liposomes coated with trimethyl chitosan: tolerance, precorneal retention and anti-cataract effect.

• Topical use of ointment with 3.5% and 5% of the extract influenced rapid wound closure rate, leading to faster epithelialization, granulation tissue resolution, and maturation at histology (Coker et al., 2018).