Assessment of the Relative Abundance of Presynaptic Sample Clauses

Assessment of the Relative Abundance of Presynaptic mGluR8 Immunoreactivity in the Mouse Striatum In this first set of experiments, we determined the frequency of mGluR8- immunoreactive glutamatergic terminals over the whole population of striatal glutamatergic boutons. To do so, immunostained tissue from the surface of striatal blocks collected from five mice was scanned for the presence of labeled and unlabeled terminals forming axo-spinous and axo-dendritic asymmetric synapses. This analysis revealed that about half (45.8% ±2.7) of all terminals forming asymmetric synapses in the striatum displayed mGluR8 immunoreactivity. More than 90% of these terminals formed axo- spinous synapses while 7.0%±1.2 were involved in axo-dendritic synapses. Based on previous tracing studies from our laboratory and others, we assume that most of these terminals in contact with dendritic shafts originate from the caudal intralaminar nuclei in the thalamus, while other boutons arise from either the cerebral cortex or other thalamic nuclei (see Xxxxx et al., 2004, 2009 for reviews). Because the use of vGluTs cannot reliably differentiate thalamostriatal from corticostriatal terminals in the mice used in these studies (see chapter 2), future tracing studies must be performed to label the thalamostriatal terminals and examine mGluR8 localization at these synapses.
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