Biomarker Analysis Sample Clauses

Biomarker Analysis. Exploratory endpoints of this trial include identification of potential biomarkers that would associate with tumor responses and evaluation of the tumor and tumor microenvironment changes in response to treatment. An attrition rate of up to 50% is expected in obtaining a pre- and on-treatment paired samples, as it might not be safe or feasible to repeat a tumor biopsy in certain patients. Additionally, some of the obtained core biopsy samples may not be evaluable. Therefore, it is anticipated there will be approximately 20 evaluable paired specimens for this cohort. As one of the measures of tumor microenvironment change in response to treatment, presence of tumor-infiltrating lymphocytes (TILs) will be quantified. Based on the literature report, a baseline CD8+ TIL of 15 cells/field (using a ×20 objective lens) is assumed, with a standard deviation of 15 cells/field.41 With 20 evaluable paired specimens, there will be 90% power to detect an increase in CD8+ TILs from 15 cells/field to 25 cells/fields (relative delta = 67% increase) at the 5% type I error rate (1 sided) under an assumption of an additive shift model with a Gaussian common density function. The incidence/changes of biomarkers will be summarized using descriptive statistics. Correlation of clinical activity with biomarker subpopulations may be performed.
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Related to Biomarker Analysis

  • Data Analysis In the meeting, the analysis that has led the College President to conclude that a reduction- in-force in the FSA at that College may be necessary will be shared. The analysis will include but is not limited to the following: ● Relationship of the FSA to the mission, vision, values, and strategic plan of the College and district ● External requirement for the services provided by the FSA such as accreditation or intergovernmental agreements ● Annual instructional load (as applicable) ● Percentage of annual instructional load taught by Residential Faculty (as applicable) ● Fall Full-Time Student Equivalent (FFTE) inclusive of dual enrollment ● Number of Residential Faculty teaching/working in the FSA ● Number of Residential Faculty whose primary FSA is the FSA being analyzed ● Revenue trends over five years for the FSA including but not limited to tuition and fees ● Expenditure trends over five years for the FSA including but not limited to personnel and capital ● Account balances for any fees accounts within the FSA ● Cost/benefit analysis of reducing all non-Residential Faculty plus one Residential Faculty within the FSA ● An explanation of the problem that reducing the number of faculty in the FSA would solve ● The list of potential Residential Faculty that are at risk of layoff as determined by the Vice Chancellor of Human Resources ● Other relevant information, as requested

  • Treatment Program Testing The Employer may request or require an employee to undergo drug and alcohol testing if the employee has been referred by the employer for chemical dependency treatment or evaluation or is participating in a chemical dependency treatment program under an employee benefit plan, in which case the employee may be requested or required to undergo drug or alcohol testing without prior notice during the evaluation or treatment period and for a period of up to two years following completion of any prescribed chemical dependency treatment program.

  • Random Drug Testing All employees covered by this Agreement shall be subject to random drug testing in accordance with Appendix D.

  • Study An application for leave of absence for professional study must be supported by a written statement indicating what study or research is to be undertaken, or, if applicable, what subjects are to be studied and at what institutions.

  • Technology Research Analyst Job# 1810 General Characteristics Maintains a strong understanding of the enterprise’s IT systems and architectures. Assists in the analysis of the requirements for the enterprise and applying emerging technologies to support long-term business objectives. Responsible for researching, collecting, and disseminating information on emerging technologies and key learnings throughout the enterprise. Researches and recommends changes to foundation architecture. Supports research projects to identify and evaluate emerging technologies. Interfaces with users and staff to evaluate possible implementation of the new technology in the enterprise, consistent with the goal of improving existing systems and technologies and in meeting the needs of the business. Analyzes and researches process of deployment and assists in this process.

  • Diagnostic procedures to aid the Provider in determining required dental treatment.

  • Laboratory Testing All laboratories selected by UPS Freight for analyzing Controlled Substances Testing will be HHS certified.

  • Clinical 2.1 Provides comprehensive evidence based nursing care to patients including assessment, intervention and evaluation.

  • Protocols Each party hereby agrees that the inclusion of additional protocols may be required to make this Agreement specific. All such protocols shall be negotiated, determined and agreed upon by both parties hereto.

  • Statistical Sampling Documentation a. A copy of the printout of the random numbers generated by the “Random Numbers” function of the statistical sampling software used by the IRO.

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