Contrast Injection Sample Clauses

Contrast Injection. A nurse, trained in intravenous contrast injections and reactions, will establish intravenous access through a peripheral vein using a catheter. The arm opposite of the breast to be scanned will be used to administer the IV contrast to reduce the chance of the contrast directly entering the veins of the scanned breast. The nurse will be present through the study. A physician will supervise the injections. A clinically certified power injector will be used to deliver a bolus injection. As a starting point, 1.5-2ml/kg body weight (100 ml maximum) of a low osmolar, nonionic, 300-350 mgI/ml iodinated contrast agent, will be injected at a rate of ~2.0 ml/s, for a total injection time of 30-60 seconds (for a 50 kg subject). This will be immediately followed by a saline “chaser” from 20 to 40 ml at ~2 ml/s (20 seconds) to maximize dynamic enhancement. A bolus test with small amount of contrast to determine the timing of the particular subject’s peak enhancement could be performed using a series of low dose pulsed scout images. (Appendices D, E, F) For those subjects who are found to have limited IV access, hand injection will be used to deliver the contrast agent. Using the same formula of 2ml/kg body weight, up to 100ml of low osmolar, nonionic 300-350 mgI/ml iodinated contrast agent will be injected over 30-60 seconds. This will be followed by a 20 to 40ml saline bolus delivered also by hand injection.