CRF Project Overview Sample Clauses

CRF Project Overview. Xxxxx et al. identified CpG sites that exhibited significantly lower methylation in the chemotherapy group than in the non-chemotherapy group and associated the lower methylation with increased inflammation markers. Increased inflammation markers were further correlated with fatigue symptoms. Xxxxx et al. observed the same results of associations 6 months post treatment. The current study aims to complete the longitudinal tracking by analyzing data from the same cohort at 1 year post treatment. In order to accomplish this, multiple sets of data from different sources will be used. It is important to clarify where, when, and how each data set is obtained (Figure 9). Baseline is the time point when all patients (n=61) enrolled into the study. At this point, the chemotherapy group already received either neoadjuvant (n=15) or adjuvant (n=7) chemotherapy, while both the chemotherapy (n=22) and non-chemotherapy (n=39) groups had undergone surgeries already and were waiting for radiotherapy regimen. Among the information collected at this time, surveys and blood work provide the fatigue, inflammation, and DNA methylation assessment. The baseline time point was established by Xxxxx et al. and DNA methylation assessment was completed using Illumina HumanMethylation 450K. Following the baseline time point is the 6 months post treatment time point. At this point, of the original participants (n=61), a subset (n=39) consented to participate further. The chemotherapy group (n=13) and non-chemotherapy group (n=26) were assessed for fatigue, inflammation, and DNA methylation again through surveys and blood work. The 6 months post treatment time point was established by Xxxxx et al. and DNA methylation assessment was completed using Illumina HumanMethylation 450K. The current study examines the 1 year post treatment time point. At this point, samples from 22 patients are available, of whom 10 received chemotherapy and 12 did not. However, only 14 of the 22 patients were among the original 61 participants, and only 8 of the patients have complete DNA methylation data from all 3 time points, while missing parts of inflammation marker assessments as well. Of the 8 patients who have complete DNA methylation data, 2 received chemotherapy and 6 did not. Although all the patients belong to the same overarching cohort, the inconsistency in subgrouping may cause errors. Furthermore, the DNA methylation assessment was completed using a new targeted bisulfite sequencing method de...
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Related to CRF Project Overview

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  • Project Oversight Inspection and acceptance of the Work shall be performed by Xxxxxxx Xxxxxxx, Project Manager of the Planning, Development & Facilities Department of the District. The architect for the Project is (N/A to this project) (“Architect”), and the Project Manager on the Project is Xxxxxxx Xxxxxxx, (“Project Manager”)

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  • Notice to Proceed - Site Improvements The Recipient shall not commence, or cause to be commenced, any site improvements or other work on the Land until the Director has issued a Notice to Proceed to the Recipient. Such Notice to Proceed will not be issued until the Director is assured that the Recipient has complied with all requirements for the approval of a grant under Revised Code Sections 164.20 through 164.27 and has completed any land acquisition required by the Project. A Notice to Proceed shall be required for all Project prime contractors or direct procurement initiated by the Recipient following execution of this Agreement.

  • Project Cost Overruns In the event that the Recipient determines that the moneys granted pursuant to Section II hereof, together with the Local Subdivision Contribution, are insufficient to pay in full the costs of the Project, the Recipient may make a request for supplemental assistance to its District Committee. The Recipient must demonstrate that such funding is necessary for the completion of the Project and the cost overrun was the result of circumstances beyond the Recipient's control, that it could not have been avoided with the exercise of due care, and that such circumstances could not have been anticipated at the time of the Recipient's initial application. Should the District Committee approve such request the action shall be recorded in the District Committee's official meeting minutes and provided to the OPWC Director for the execution of an amendment to this Agreement.

  • Project Implementation 2. The Borrower shall:

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