Determination of individual dose Sample Clauses

Determination of individual dose toxicity between cell lines In order to determine whether SH-SY5Y and S.NNMT.LP cells exhibited significant differences in viability or ATP content at individual concentrations, a 2-way repeated-measures ANOVA using blocked, mean data for each experiment was performed with concentration and cell line as the two independent variables and data normalised as percentage of untreated (control) cells as the dependent variable. Data were normalised in order to take into account differences in baseline between both cell lines. Control data were not included in the analysis as, due to the normalisation process, these would violate the assumption of the ANOVA of an equal distribution of variability amongst the data. Data were blocked for individual experiments to take into account the week-to-week variation.
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