General Methods Sample Clauses

General Methods. The most commonly used methods and techniques are described in this chapter. Methods that were used less frequently will be described in detail in their relevant chapters.
Sample 1
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General Methods i. Reagents Lapatinib was purchased from Santa Xxxx Biotechnology (Santa Cruz, CA). Lapatinib for in vitro studies was purchased from Santa Xxxx, Biotech (Santa Cruz, CA), and dissolved in dimethyl sulfoxide (DMSO) at a stock concentration of 10 mM. Lapatinib for in vivo studies was purchased from the Xxxxxxx Cancer Institute pharmacy and dissolved in 1% Tween 80 at a stock concentration of 7.5 mg/mL. Rapamycin mTOR inhibitor (Sigma-Xxxxxxx; St. Xxxxx, MO) was supplied as a 2.74 mM solution in DMSO. MK-8669 (ridaforolimus, supplied by Merck through an MTA) was dissolved in DMSO at stock concentration of 10 mM for in vitro studies. For in vivo studies, MK-8669 was dissolved fresh daily in 10% Tween 80 and 40% PEG-400 in sterile water at stock 1 mg/mL as recommended by Merck. Trastuzumab was purchased from the Xxxxxxx Cancer Institute pharmacy and dissolved in sterile water at a stock concentration of 20 mg/mL. Selumetinib was purchased from LC Laboratories (Woburn, MA), PD0325901 was purchased from Cayman Chemical (Ann Arbor, MI). Thiostrepton was purchased from Sigma-Xxxxxxx (St. Xxxxx, MO). Lapatinib was dissolved in DMSO at a stock concentration of 10 mM, and thiostrepton was dissolved at a stock concentration of 50 mM. Lapatinib for in vivo studies was purchased from the Xxxxxxx Cancer Institute pharmacy and dissolved in a 1% Tween 80 and 5% hydroxypropyl methylcellulose buffer just prior to use.
Sample 1
General Methods. Any external or interconnecting cable, where a ground is part of the circuit, shall carry a ground wire in the cable terminated at both ends in the same manner as the other conductors. In no case, except with coaxial cables, shall the shield be depended upon for a current-carrying ground connection. Static and safety grounds shall not be used to complete electrical circuits. A point on the electrically conductive chassis or equipment frame shall serve as the common tie point for static and safety grounding. The path from the tie point to ground shall:
Sample 1
General Methods. THE MR XXXXXX STUDY Some of the patients used in the comparative studies between FFR and CMR were recruited to take part in the MR-INFORM clinical trial. (XxxxxxxxXxxxxx.xxx Identifier:NCT01236807) This is an international randomised controlled trial of FFR vs. CMR to guide the management of patients with coronary artery disease and is still currently recruiting. Currently there are over 600 patients recruited to this study, which aims to recruit 918 patients. Analysis of subgroups where there is discordance between the two tests is part of the exploratory endpoints of the main trial. One of the disadvantages of using these patients is that the power calculations are based on the primary endpoint of the main clinical trial. However, these patients are a particularly interesting sub group as they have had both an invasive and non-invasive assessment of ischaemia. In addition, some patients were recruited from a second site, Porto in Portugal under the direction of Dr Xxxx Xxxxxxxxxxx. In this chapter I will describe the general methods of the main MR-INFORM trial. My involvement in this study was writing the protocol, finalising the trial design including all important decisions on the nature of the trial, definition of end points, statistical power etc. Furthermore, I proceeded to get regulatory approval for the study, and set up enough sites to ensure adequate recruitment both nationally and internationally. Additionally, I recruited patients from our site and was responsible for the CMR scanning and follow up of these patients. The following chapter is adapted from the following publication: Hussain ST, Paul M, Xxxxx S, XxXxxx XX, Xxxx AM, Xxxxxx MS, et al. Design and rationale of the MR-INFORM study: stress perfusion cardiovascular magnetic resonance imaging to guide the management of patients with stable coronary artery disease. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance. 2012;14:65(113)
Sample 1

Related to General Methods

  • Payment Methods A. Except as otherwise provided by this Contract, the payment method will be one or more of the following:

  • Payment Methodology The Contractor shall be compensated based on the Service Rates in Attachment for units of service authorized by the Institution in a total amount not to exceed the Contract Maximum Liability established in Section C.1. The Contractor’s compensation shall be contingent upon the satisfactory completion of units of service or project milestones identified in Attachment B. The Contractor shall submit invoices, in form and substance acceptable to the Institution with all of the necessary supporting documentation, prior to any payment. Such invoices shall be submitted for completed units of service or project milestones for the amount stipulated.

  • Selection of Mediator A single mediator that is acceptable to both parties shall be used to mediate the dispute. The mediator will be knowledgeable in the subject matter of this Contract, if possible.

  • Test method 3.3.1. The method used shall be that described in Annex 3, paragraph 3.1.

  • NON-NETWORK PROVIDER is a provider that has not entered into a contract with us or any other Blue Cross and Blue Shield plan. For pediatric dental care services, non-network provider is a dentist that has not entered into a contract with us or does not participate in the Dental Coast to Coast Network. For pediatric vision hardware services, a non-network provider is a provider that has not entered into a contract with EyeMed, our vision care service manager.

  • Standard Service Features Ethernet Access allows Customer to terminate single and/or multiple Ethernet Virtual Circuits (EVCs) from Customer equipment onto a single Ethernet Access UNI.

  • Model List your model number of the product you are bidding.

  • Hot Weather Guidelines For the purposes of site based discussions regarding the need to plan and perform work during expected periods of hot weather, the following issues shall be considered in conjunction with proper consideration of Occupational Health and Safety issues.

  • BRAND NAME OR EQUALS/DEVIATIONS Unless otherwise specified, the mention of a particular manufacturer’s brand name or number in the specifications does not imply that this particular good is the only one that will be considered for purchase. This reference is intended solely to designate the type or quality of good that will be acceptable. Equal offers will be considered and must include descriptive literature and/or specifications. Failure to provide descriptive literature and/or specifications with equal offers will result in the disqualification of the bid. The determination as to whether any alternate good or service is or is not equal shall be made solely by the County and such determination shall be final and binding upon all bidders. The County reserves the right to request and review additional information to make such a determination. Although the County provides for the consideration of alternate bids, it reserves the right to make an award in the best interest of the County. Award may not necessarily be given to the lowest bid offered. The Bidder shall be responsible for reading very carefully, and understanding completely, the requirements and the specifications of the items bid upon. Unless the bid is in response to a “Brand Name or Equal” requirement, deviations from the specifications will only be considered if requested in writing prior to the date and time specified for receipt of bids. Deviations, if accepted, will be specifically addressed in writing via an addendum to this Invitation for Bids. Any goods or services that are not in compliance with the specifications will not be accepted.

  • Switching System Hierarchy and Trunking Requirements For purposes of routing ECI traffic to Verizon, the subtending arrangements between Verizon Tandem Switches and Verizon End Office Switches shall be the same as the Tandem/End Office subtending arrangements Verizon maintains for the routing of its own or other carriers’ traffic (i.e., traffic will be routed to the appropriate Verizon Tandem subtended by the terminating End Office serving the Verizon Customer). For purposes of routing Verizon traffic to ECI, the subtending arrangements between ECI Tandem Switches and ECI End Office Switches shall be the same as the Tandem/End Office subtending arrangements that ECI maintains for the routing of its own or other carriers’ traffic.

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