Effect of MDA on ADL Incidence Sample Clauses

Effect of MDA on ADL Incidence. Some studies have reported that the incidence of ADL may decrease following mass drug administration (MDA). A study in Xxxxxx, India evaluating the efficacy of DEC treatment over a 12 year period [49] found that the rate of ADL decreased from 46% in 1977 to 11% in 1988. However, 10 consistent days of DEC treatment was given en masse in 1977 and 1980, while it was selectively given in 1978, 1979, 1981, and 1982. Selective treatment was given in order of the following criteria: 1) all new residents 2) those who were mf (+) before initial treatment 3) those with a history of adenolymphangitis over previous 1-year period. Furthermore, those who presented with acute symptoms of adenolymphangitis were immediately treated with a single course of DEC. So results of this study may not be generalizable to MDA programs where all individuals in a community are treated with DEC annually. A 5-year follow-up of acute filarial morbidity (AFM) [44] found an overall decrease in AFM incidence after 4 rounds of annual MDA in Papua New Guinea. The incidence decreased from 0.39 per person- year in the pre-treatment year to 0.19 per person-year following a 4th annual round of MDA. The lowest incidence occurred following the 2nd annual round of MDA, 0.15 per person-year. This detailed weekly follow-up of AFM is one of the most rigorous calculations of AFM incidence in an LF endemic community.
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