Emulsification-solvent evaporation Sample Clauses

Emulsification-solvent evaporation. The emulsification-solvent evaporation method was the first method used to prepare biodegradable and injectable lattices by Gurny et al. (1981). Briefly, this method is carried out by dissolving the drug and polymer are in a volatile, water immiscible organic solvent such as dicholoromethane, chloroform or ethyl acetate. The emulsion is prepared by adding water and a surfactant to the polymer solution. The nanosized polymeric droplets are induced using high energy homogenization or sonicator. The organic phase evaporation is achieved using a rotary evaporator or by continuous stirring and the nanoparticles are collected by centrifugation or lyophilisation (Xxxxx et al., 1998).
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