General Introduction. This Scope of Work provides an overall description of Contractor’s responsibilities for the design, engineering, procurement, manufacture, management, construction, installation, testing, commissioning, Start Up, initial operations, and Performance Testing of the Stage 2 Liquefaction Facility. All obligations and responsibilities referred to in this Attachment A are Contractor’s obligations and responsibilities, unless expressly stated to be the obligation of Owner or a third Person.
General Introduction. This Scope of Work provides an overall description of Contractor’s responsibilities for the design, engineering, procurement, manufacture, management, construction, installation, testing, commissioning, Start Up, initial operations, and Performance Testing, of the Liquefaction Facility and certain modifications and improvements to the Existing Facility. The Site is located off Gulf Beach Highway 82 on 853 acres of land along the Sabine Pass Navigation Channel on the border between Texas and Louisiana, in Cameron Parish, Louisiana, as further defined in Attachment Y. Located within the Site boundaries are Existing Facility’s marine facilities designed to load and unload LNG carriers located on the Sabine Pass Navigation Channel, 3.7 nautical miles from the open water and 23 nautical miles from the outer buoy. All obligations and responsibilities referred to in this Attachment A are Contractor’s obligations and responsibilities, unless expressly stated to be the obligation of Owner or a third Person.
General Introduction. This Scope of Work provides an overall description of Contractor’s responsibilities for the design, engineering, procurement, manufacture, management, construction, installation, testing, commissioning, Start Up, initial operations, and Performance Testing, of the Stage 2 Liquefaction Facility and certain modifications and improvements to the Existing Facility and Stage 1 Liquefaction Facility. The Site is located off Gulf Beach Highway 82 on 853 acres of land along the Sabine Pass Navigation Channel on the border between Texas and Louisiana, in Cameron Parish, Louisiana, as further defined in Attachment Y. Located within the Site boundaries are Existing Facility’s marine facilities designed to load and unload LNG carriers located on the Sabine Pass Navigation Channel, 3.7 nautical miles from the open water and 23 nautical miles from the outer buoy. All obligations and responsibilities referred to in this Attachment A are Contractor’s obligations and responsibilities, unless expressly stated to be the obligation of Owner or a third Person.
General Introduction. 1.1 The Chief Procurement Officer for the Department of General Services (“Department”), Bureau of Procurement, is issuing these contract compliance review guidelines.
General Introduction. The principal aim of this book is to study three important construction rituals of the Hindu tradition: the laying of the first stones, the placing of the consecration deposit and the placing of the crowning bricks. These rituals are described in numerous Sanskrit texts on architecture and religion, which date from ca. 7th to 16th centuries AD.1 It is therefore hardly surprising that the present study is based mainly on textual sources. The chief source is the Kâśyapaśilpa, a South Indian treatise on art and architecture and ritual, written in Sanskrit, usually dated 11th – 12th century AD. Three chapters from the Kâśyapaśilpa, which deal with the three construction rituals mentioned above, have been critically edited, translated and provided with a commentary (see Chapter 4). For this purpose, unpublished manuscripts of the Kâśyapaśilpa were collected in various Southern Indian libraries. In order to place the three chapters of the Kâśyapaśilpa in a broader context, the descriptions of the construction rituals given by cognate texts, some of them still unpublished, have also been studied (see Chapter 5). The construction rites play an important role in Sanskrit texts on ritual and architecture. Nevertheless, this topic has thus far largely been neglected by scholars. This is particularly striking in view of the numerous publications, which have appeared on the outer appearance of temples, the technical aspects of temple building and temple worship. With the exception of Xxxxxxxxx (1946), whose interpretations should be treated with caution (see, for example, Chapter 6 note 12), there has never been an attempt to study the construction rituals as a whole and to explain their function and meaning. For those who want to arrive at an understanding of the construction rituals, textual sources alone are not sufficient. The texts are mainly technical treatises, which provide only a very limited interpretation for the actions they describe. Moreover, for the questions about the relation between the textual data and practice the answer has to be sought outside the textual sources. Have rituals, such as those described by the Kâśyapaśilpa and the related works, ever been performed? And if so, were the rituals performed according to the textual prescriptions?
General Introduction. The studies presented in this thesis stem from an interest in Roma’s fate which entails a challenge of immense practical importance. Negative attitudes towards the Roma have been a common denominator of widespread rejection, exclusion and outright hostility that marked the eight-century-long Roma history in Europe (Crowe, 2008). In recent years, an increasing ethnic mobility within the European Union enabled the Roma to travel from one country to another to escape discrimination and search for a better life (European Union Agency for Fundamental Rights, 2009). Most of Roma, however, remain excluded from the mainstream population, and face continued poverty and discrimination (Kostadinova, 2011). The goal of this dissertation is to provide an insight into social-psychological mechanisms that underlie this appalling situation of European Roma. We refer to negative attitudes towards the Roma as Romaphobia1. Like other type of outgroup attitudes, Xxxxxxxxxx reflects negative emotions associated with group membership,
General Introduction. The Government of Madhya Pradesh is poised for rapid growth of infrastructure in the state. Medical Education Dept. through Madhya Pradesh Road Development Corporation (the Authority) intends for development of 100 seats Medical College of Graduate Level, associated 500 bedded Hospital Complex at Shahdol in the state of Madhya Pradesh on BOT (Annuity) basis. Shahdol is the administrative headquarters of Shahdol District. Adjacents to the District Shahdol are the boarding districts Dindori, Satna, Sidhi, Umaria, Anuppur and Rewa.
General Introduction. (a) First Data shall provide to RCSI and its Affiliates the Production Services generally described in Section 3 of this Agreement and set forth with more particularity in this Schedule A. First Data shall provide the Production Services so as to comply with the Service Levels, the RCSI Rules and maintain the ISO standards and certifications achieved by RCSI or its Affiliates prior to the Effective Date.
General Introduction. About this thesis “A journey of a thousand miles begins with a single step (千里之行始于足下)”. Similarly, pharmacological effects are triggered by the initial step of drug-target binding. This thesis focuses on the kinetics of binding interactions between ligands (drugs) and various G protein-coupled receptors (GPCR). GPCR are one of the largest and most important drug target families; many drugs in use today target these pharmaceutically relevant proteins.1 However, many candidate drugs are still neither efficacious nor safe.2 Thus the traditional affinity- or potency-based rationale in the early phases of drug discovery may need to be reconsidered. Although binding kinetics. i.e. the rate with which a ligand associates to and dissociates from the target, has been studied on a few drug target classes, the concept of binding kinetics has been emerging over the last decade as an additional and relevant selection criterion in the drug discovery pipeline.3, 4 To describe the importance and relevance of the research performed in this thesis, this chapter serves as a general introduction. First, the GPCR will be introduced. Second, the two families of human cannabinoid and human adenosine receptors will be mentioned; more specifically, both the human cannabinoid receptor 1 (hCB1) and the human adenosine A1 and A3 (hA1 and hA3) receptors will be outlined as prototypical GPCR as well as potential drug targets. These targets are then the main “actors” in the subsequent experimental chapters of this thesis. Furthermore, the concept of binding kinetics will be presented in a chronological way, including some practical requirements for the early phase of drug discovery. Finally, the aim and scope of this thesis will be explained. What are GPCR ? GPCR are membrane bound proteins, composed of seven transmembrane helices with extracellular and intracellular loops and an extracellular (N-terminal) and intracellular (C-terminal) tail. They play key roles in physiology by detecting external stimuli (e.g. chemical small molecules, endogenous ligands, or photons) and activating internal signal transduction pathways and eventually physiological responses (Figure 1A). An agonist is able to bind to and activate a GPCR to produce a biological response. In contrast, a (neutral) antagonist blocks the action of the (endogenous) agonist, while an inverse agonist causes an action opposite to that of the agonist, i.e. decreasing the basal level of receptor activity (Figure 1B). Since GPCR ar...
General Introduction. Hemophilia Hemophilia is a hereditary clotting disorder which is caused by a deficiency of factor VIII (hemophilia A) or IX (hemophilia B). In the Netherlands the prevalence is around 10 per 100,000, resulting in about 1600 patients1. The severity of the disease is determined by the residual clotting factor activity. Patients with mild hemophilia (>0.05-0.40 IU/ml) show little spontaneous bleeding and bleed excessively only after major trauma; patients with moderate hemophilia (0.01-0.05 IU/ml) may show excessive hemorrhages after minor trauma, while severe hemophilia (<0.01 IU/ml) is characterized by major bleeding occurring spontaneously or after minor trauma. Frequent bleeding in joints results into damage of the synovial tissue and arthropathy. Hemophilia is a genetic recessive X-linked trait and therefore patients are mostly men. Female family members can be carriers of the disorder, which is characterized by a 25% chance of having a son with hemophilia, and a decreased clotting factor activity level.
