EWOC-NETS Sample Clauses

EWOC-NETS. In combining Escalation with Overdose Control (EWOC) with NETS to utilize all toxicity data available, we must redefine certain parameters. The target toxicity level (TTL) defined by θ is analogously defined to be a pre-specified target normalized equivalent toxicity score (TNETS). Therefore, the formal definition of TNETS is the score at which the MTD γ will converge. For consistency, we define θ to be TNETS in this section. The estimate of θ is defined to be a summation of the mid-range NETS score ml and the target probability corresponding to the maximum adjusted grade l toxicity (pl). Therefore, θˆ is defined as: Σ θˆ = mlpl (14) Similar to EWOC from Section 2.1, we model toxicity in the form of a logistic model. Previously, EWOC modeled toxicity as a binary result. We can now model the NETS using a similar model:
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Related to EWOC-NETS

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