Common use of Expansion Clause in Contracts

Expansion. Effective as of the Expansion Effective Date (defined below), the Premises, as defined in the Lease, is increased from 25,805 rentable square feet on the 14th floor to 36,385 rentable square feet on the 14th and 17th floors by the addition of the Expansion Space, and from and after the Expansion Effective Date, the Original Premises and the Expansion Space, collectively, shall be deemed the Premises, as defined in the Lease. The Term for the Expansion Space shall commence on the Expansion Effective Date and end on the Termination Date (as defined in the Lease). The Expansion Space is subject to all the terms and conditions of the Lease (including all restrictions set forth in Section 5 of the Lease, provided that in no event shall any portion of the Landlord Work, as hereinafter defined, performed by Landlord in the Expansion Space prior the delivery of same to Tenant be deemed to create any Tenant Triggered Compliance obligations), except as expressly modified herein and except that Tenant shall not be entitled to receive any allowances, abatements or other financial concessions granted with respect to the Original Premises unless such concessions are expressly provided for herein with respect to the Expansion Space. Landlord and Tenant stipulate and agree that the rentable square footage of the Expansion Space is correct and shall not be remeasured, unless there is an actual physical change in the Expansion Space. Tenant shall deliver to Landlord the first month’s estimated gross Rent obligation concurrently with its delivery of the Tenant-executed copy of this Amendment.

Expansion. Effective as of the Eleventh Expansion Effective Space Commencement Date (defined belowhereinafter defined), the Premises, as defined in the Lease, Lease is increased from 25,805 hereby modified and amended to include approximately 17,376 rentable square feet feet, located on the 14th 12th floor to 36,385 rentable square feet of 000 Xxxxxxxx Xxxxx as shown on Exhibit A attached hereto (the 14th and 17th floors by the addition of the "Eleventh Expansion Space, and from and after the Expansion Effective Date, the Original Premises and the Expansion Space, collectively, shall be deemed the Premises, as defined in the Lease. The Term for the Expansion Space shall commence on the Expansion Effective Date and end on the Termination Date (as defined in the Lease"). The rentable square footage of the Eleventh Expansion Space is subject to all final measurement and adjustment based on the terms and conditions of the Lease Construction Documents (including all restrictions set forth in Section 5 of the Lease, provided that in no event shall any portion of the Landlord Work, as hereinafter defined, performed by Landlord defined in the Expansion Space prior the delivery of same to Tenant be deemed to create any Tenant Triggered Compliance obligationsWork Letter attached as Exhibit B), except as expressly modified herein and except that Tenant shall not be entitled to receive any allowances, abatements or other financial concessions granted in accordance with respect to 1996 BOMA measurement standards (ANSI/BOMA 265.1- 1996) for multi-tenant buildings using the Original Premises unless Building standard Common Area factor for multi-tenant floors in the Building. If such concessions are expressly provided for herein with respect to the Expansion Space. Landlord and Tenant stipulate and agree that measurement results in a change in the rentable square footage of the Eleventh Expansion Space, the Basic Rental Tenant's proportionate share, the parking permits made available to Tenant and any other concessions based on the rentable square footage of the Eleventh Expansion Space shall be adjusted accordingly. Tenant shall, within 15 days after Landlord's written request, execute and return a lease amendment effective as of the Eleventh Expansion Space Commencement Date, confirming the necessary adjustments. As used herein, the term "Eleventh Expansion Space Commencement Date" shall be the earliest of (1) the first business day after the date on which the Landlord Work (defined in the Work Letter attached as Exhibit B) with respect to the Eleventh Expansion Space is correct and shall not be remeasuredSubstantially Complete, unless there as determined pursuant to the Work Letter, or (2) the date on which the Landlord Work with respect to the Eleventh Expansion Space would have been Substantially Complete but for Tenant Delay, as such term is an actual physical change defined in the Work Letter, or (3) the date Tenant takes possession of any part of the Eleventh Expansion SpaceSpace for purposes of conducting business therein. Tenant shall deliver hereby acknowledges and agrees that the Eleventh Expansion Space is leased by Tenant subject to Landlord the first month’s estimated gross Rent obligation concurrently with its delivery all terms and conditions of the Tenant-executed copy of Lease, as modified by this AmendmentFifteenth Modification.

Expansion. Effective as Tenant leases from Landlord an additional 11,656 Rentable Square Feet in Suite 700 on the 7th floor of the Building (the “Second Expansion Effective Date Space”) as depicted on the attached Exhibit A. The Lease term for the Second Expansion Space shall commence upon April 1, 2007 (defined belowthe “Second Expansion Space Commencement Date”), and shall run concurrent with the Term of the Lease. Effective upon the Second Expansion Space Commencement Date the “Premises, as defined in ” shall be deemed to include the Current Premises and the Second Expansion Space for all purposes of the Lease, and will consist of a total of 52,120 Rentable Square Feet. In connection with the foregoing, Landlord agrees that Tenant may enter the Second Expansion Space on or after February 17, 2007 for the sole purpose of installation of furniture, fixtures and equipment (the “Early Entry”) provided that such Early Entry is increased from 25,805 rentable square feet on conducted in a manner as to not unreasonably interfere with any Landlord Work occurring in or around the 14th floor to 36,385 rentable square feet on the 14th and 17th floors by the addition of the Second Expansion Space, and from and after the Expansion Effective Date, the Original Premises and the Expansion Space, collectively, further provided that such Early Entry shall be deemed the Premises, as defined in the Lease. The Term for the Expansion Space shall commence on the Expansion Effective Date and end on the Termination Date (as defined in the Lease). The Expansion Space is subject to all of the terms and conditions of contained in the Lease (including all restrictions set forth other than the payment of Base Rent and Tenant’s Pro Rata Share of Excess Operating Expenses), including, without limitation, Tenant’s insurance and indemnity obligations as contained in Section 5 this Lease. Prior to any such Early Entry, Tenant shall provide Landlord with certificates of insurance or other evidence acceptable to Landlord evidencing Tenant’s compliance with its insurance obligations. In the Lease, provided event that in no event shall any portion of Tenant’s Early Entry interferes with the Landlord Work, as hereinafter defined, performed by Landlord Work or otherwise disrupts Landlord’s operations or the operations of other tenants in the Expansion Space prior Building, Landlord may terminate Tenant’s right to Early Entry, and any delay in the delivery of same Landlord Work attributable to Tenant such Early Entry will be deemed to create any a Tenant Triggered Compliance obligations), except Delay as expressly modified herein and except that Tenant shall not be entitled to receive any allowances, abatements or other financial concessions granted with respect to the Original Premises unless such concessions are expressly provided for herein with respect to the Expansion Space. Landlord and Tenant stipulate and agree that the rentable square footage of the Expansion Space is correct and shall not be remeasured, unless there is an actual physical change in the Expansion Space. Tenant shall deliver to Landlord the first month’s estimated gross Rent obligation concurrently with its delivery of the Tenant-executed copy of this Amendmentattached Work Letter.

Expansion. Effective as Tenant has exercised Tenant's Refusal Right with respect to the Refusal Space, consisting of the Expansion Effective Date (defined below), the Premises, as defined in the Lease, is increased from 25,805 9,040 rentable square feet on the 14th floor of space located adjacent to 36,385 rentable square feet on the 14th and 17th floors by the addition of the Expansion Space, and from and after the Expansion Effective Date, the Original Premises and the Expansion more particularly identified on Exhibit A attached hereto and incorporated herein by this reference ("Additional Space, collectively, shall be deemed the Premises, as defined in the Lease. The Term for the Expansion Space shall commence on the Expansion Effective Date and end on the Termination Date (as defined in the Lease"). The Expansion Additional Space, together with the Original Premises, aggregating 33,025 rentable square feet, is leased by Tenant on the following terms and conditions: (a) The Additional Space is subject leased in its "as is," "where is," existing condition. Landlord shall have no obligation to all make any improvements whatsoever in the Additional Space. (b) Notwithstanding the foregoing, Landlord shall give Tenant a tenant finish allowance for the Additional Space in the amount of $22.00 per rentable square foot of the Additional Space (i.e. $198,880.00) ("Additional Space Allowance"). The Additional Space Allowance shall be paid by Landlord to Tenant on the same terms and conditions as provided in the Lease with respect to payment by Landlord of the Lease Tenant Finish allowance. (including all restrictions c) On December 1, 1999, Tenant shall commence paying Base Rent on the Additional Space as hereinafter set forth in Section 5 an amount of $13.80 per rentable square foot of the Lease, provided that in no event shall any portion Additional Space for the first 36 months and $15.04 per rentable square foot of the Landlord WorkAdditional Space for the balance of the Primary Lease Term, as hereinafter defined, performed by Landlord in the Expansion Space prior the delivery of same to Tenant be deemed to create any Tenant Triggered Compliance obligations), except as expressly modified herein and except that Tenant shall not be entitled to receive any allowances, abatements or other financial concessions granted with respect to the Original Premises unless such concessions are expressly provided for herein with respect to the Expansion Space. Landlord and Tenant stipulate and agree that the rentable square footage of the Expansion Space is correct and shall not be remeasured, unless there is an actual physical change in the Expansion Space. Tenant shall deliver to Landlord the first month’s estimated gross Rent obligation concurrently with its delivery of the Tenant-executed copy of this Amendment.

Expansion. Effective as of the Expansion Effective Date (defined below), the Premises, as defined in the Lease, is increased Landlord hereby leases to Tenant and Tenant hereby rents from 25,805 Landlord an additional 15,078 rentable square feet on the 14th floor located adjacent to 36,385 rentable square feet on the 14th and 17th floors by the addition of the Expansion Space, and from and after the Expansion Effective Date, the Original Premises and the Expansion more commonly known as Suite 200, as identified on Exhibit A attached hereto and incorporated herein by this reference ("Additional Space"). The Additional Space, collectivelytogether with the Original Premises, aggregate 24,118, and is hereinafter referred to collectively as the "Premises." The Additional Space is leased by Tenant on the following terms and conditions: A. The Additional Space shall be deemed completed in accordance with the Premisesterms of the Work Letter attached as Exhibit D to the Original Lease, as defined except that the Submission Date with respect to Tenant's delivery of space plans for the Additional Space shall be October 1, 1999 and the Premises shall be Ready for Occupancy on or before January 1, 2000. Landlord shall give Tenant a tenant finish allowance for the Additional Space in the amount of $22.00 per rentable square foot of the Additional Space (i.e. $331,716.00) ("Additional Space Allowance"). The Additional Space Allowance shall be paid by Landlord to Tenant on the same terms and conditions as provided in the Lease with respect to payment by Landlord of the Tenant Finish Allowance. B. On January 1, 2000, Tenant shall commence paying Base Rent and Additional Rent on the Additional Space as hereinafter set forth. C. Simultaneously with execution of this Amendment, Tenant shall increase the Security Deposit by depositing with Landlord an additional Seventeen Thousand Three Hundred Thirty-Nine and 70/100 Dollars ($17,339.70) to be held by Landlord in accordance with Section 4 of the Original Lease. The Term for aggregate amount of the Expansion Security Deposit to be held by Landlord shall be $28,108.70. D. Tenant's Pro Rata Share is equal to 24.63%. E. Except as modified by this Amendment, all other terms and provisions of the Original Lease shall apply to Tenant's lease of the Additional Space shall commence on the Expansion Effective Date and end on the Termination Date (as defined all references in the Lease). The Expansion Space is subject to all the terms and conditions of the Lease (including all restrictions set forth in Section 5 of the Lease, provided that in no event shall any portion of the Landlord Work, as hereinafter defined, performed by Landlord in the Expansion Space prior the delivery of same to Tenant be deemed to create any Tenant Triggered Compliance obligations), except as expressly modified herein and except that Tenant shall not be entitled to receive any allowances, abatements or other financial concessions granted with respect to the Original Premises unless such concessions are expressly provided for herein with respect to "Premises" shall include the Expansion Additional Space. Landlord and Tenant stipulate and agree that the rentable square footage of the Expansion Space is correct and shall not be remeasured, unless there is an actual physical change in the Expansion Space. Tenant shall deliver to Landlord the first month’s estimated gross Rent obligation concurrently with its delivery of the Tenant-executed copy of this Amendment.

Expansion. Effective Upon receipt of written notice from Landlord that the lease for approximately 21,550 rentable square feet to BG Medicine, Inc. (the “BG Lease”) has terminated and that the BG Expansion Premises are being delivered to Tenant, the Premises shall automatically expand in accordance with this Section 2.1.2 to include an additional 21,550 rentable square feet of space in the Building (the “BG Expansion Premises”), which BG Expansion Premises is more particularly shown on the plan attached hereto as Exhibit A-1. Following the expansion described in this Section 2.1.2, the Premises will include all common areas of the Building. The lease of the BG Expansion Premises shall be on the same terms and conditions that are set forth in this Lease for the Premises, including without limitation, Section 2.4.1 below, except that the Rent Commencement Date for the BG Expansion Premises shall be ninety (90) days after the date on which the BG Expansion Premises are delivered to Tenant in accordance herewith (the “BG Delivery Date”), the Improvement Allowance for the BG Expansion Premises shall be $495,650 and the Space Planning Allowance for the BG Expansion Premises shall be $48,487.50. The provisions of this Section 2.1.2 shall be self-operative, but at either party’s request, Landlord and Tenant shall enter into an amendment to this Lease to reflect the expansion of the Premises to include the BG Expansion Premises. The BG Expansion Premises shall be delivered to Tenant in “broom clean” condition, but including all biotechnology trade fixtures that are affixed to the BG Expansion Premises as of the Expansion Effective date hereof, including any benches, cabinets and racks, and free of all tenants and occupants, and such delivery shall be subject to the provisions of Section 2.4(d) below. The term of the BG Lease is scheduled to expire on June 30, 2008 (and the tenant thereunder is entitled to an extension term of one (1) additional year). Notwithstanding the provisions of this Section 2.1.2, the BG Delivery Date shall not occur prior to June 30, 2009 and no later than July 1, 2010 (defined belowthe “BG Outside Delivery Date”), the Premises, as defined in the Lease, is increased from 25,805 rentable square feet on the 14th floor to 36,385 rentable square feet on the 14th and 17th floors by the addition of the Expansion Space, and from and after the Expansion Effective Date, the Original Premises and the Expansion Space, collectively, shall be deemed the Premises, as defined in the Lease. The Term for the Expansion Space shall commence on the Expansion Effective Date and end on the Termination Date (as defined in the Lease). The Expansion Space is subject to all the terms and conditions of the Lease (including all restrictions set forth in Section 5 of the Lease, provided that in no event shall any portion of the Landlord Work, as hereinafter defined, performed by Landlord in the Expansion Space prior the delivery of same to Tenant be deemed to create any Tenant Triggered Compliance obligations), except as expressly modified herein and except it being agreed that Tenant shall not be entitled to receive any allowances, abatements or other financial concessions granted with respect may terminate its rights to the Original BG Expansion Premises unless such concessions are expressly provided for herein with respect to if the Expansion Space. Landlord and Tenant stipulate and agree that BG Delivery date occurs later than the rentable square footage of the Expansion Space is correct and shall not be remeasured, unless there is an actual physical change in the Expansion Space. Tenant shall deliver to Landlord the first month’s estimated gross Rent obligation concurrently with its delivery of the Tenant-executed copy of this AmendmentOutside BG Delivery Date.

Expansion. Effective 24.1 Landlord agrees that Tenant shall have the right, at any time and from time to time during the Lease Term, to lease additional space in the Building which is contiguous to the Premises (the "Additional Space") as it becomes available following the vacation of such leased space by the then current tenant of such space, subject to the following terms and conditions: (a) Landlord shall notify Tenant of the Expansion Effective Date availability of the Additional Space. (defined below), b) The annual base rent and additional rent with respect to the Premises, as defined Additional Space shall be the same amount per square foot and shall be adjusted at the same time and in the Leasesame manner as the adjusted annual base rent and additional rent then in effect with respect to the original Premises. (c) For a period of ten (10) days after receipt of any such notice from Landlord, is increased Tenant shall have the right to lease the Additional Space from 25,805 rentable square feet on the 14th floor to 36,385 rentable square feet on the 14th and 17th floors by the addition of the Expansion Space, and from and after the Expansion Effective Date, the Original Premises and the Expansion Space, collectively, shall be deemed the Premises, as defined in the Lease. The Term for the Expansion Space shall commence on the Expansion Effective Date and end on the Termination Date (as defined in the Lease). The Expansion Space is subject to all Landlord upon the terms and conditions of the Lease (including all restrictions set forth in Section 5 this Lease (but without any obligation on the part of Landlord to construct, alter, renovate, repaint, recarpet or provide any construction allowance for tenant improvements in the Premises) commencing on the date the Additional Space becomes available as set forth in the notice from Landlord. In the event Tenant agrees to lease the Additional Space within such ten (10) day period, Landlord and Tenant shall promptly execute an amendment to the Lease indicating the location and configuration of the Additional Space. The number of square feet of rentable area of the Premises shall be measured and calculated by Landlord's architect in accordance with the provisions of Exhibit E attached hereto and shall be set forth in the amendment to the Lease, provided that in . (d) In no event shall any portion Tenant have the right to lease less than all of the Landlord Work, as hereinafter defined, performed by Landlord in the Expansion Additional Space prior the delivery of same to Tenant be deemed to create any Tenant Triggered Compliance obligations), except as expressly modified herein and except that available. (e) Tenant shall not be entitled accept the Additional Space in "as is" condition and Landlord shall have no obligation to receive any allowances, abatements or other financial concessions granted provide Tenant with an improvement allowance with respect to the Original Premises unless such concessions are expressly provided for herein with respect to the Expansion Additional Space. Landlord and Tenant stipulate and agree that the rentable square footage of the Expansion Space is correct and shall not be remeasured, unless there is an actual physical change All work performed in the Expansion Space. Tenant Additional Space shall deliver to Landlord be performed in accordance with the first month’s estimated gross Rent obligation concurrently with its delivery of the Tenant-executed copy terms and provisions of this AmendmentLease.