Gastro-Intestinal Inflammation Sample Clauses

Gastro-Intestinal Inflammation. (Fecal Calprotectin) The pathophysiologic triad of obstruction, infection and inflammation can be seen in the intestinal tract as well as in the airways. Although the exact underlying mechanism of GI tract inflammation is unknown, dysfunctional CFTR is thought to be the inciting factor.50 Endoscopic lavage of the CF small intestine showed increased levels of inflammatory markers in the lumen.51 A conventional endoscopic study showed that the CF duodenum was morphologically normal but there were increased levels of several inflammatory markers in biopsied tissue.52 More recent work using video equipped capsule endoscopy showed that morphological abnormalities occur in the jejunum and ileum in more than 60% of CF patients which include edema, erythema, mucosal breaks, and ulcerations.53 That study also reported significant elevations of fecal calprotectin (a neutrophil secretory product) in many CF patients, consistent with intestinal inflammation. These inflammatory markers are seen in PS as well as PI patients, indicating that CFTR dysfunction leads to “CF enteropathy” rather than inflammation being caused by local irritation from pancreatic enzyme replacement therapy.54 Inflammation is a feature of intestinal as well as airway disease. Fecal calprotectin, a neutrophil secretory product indicative of GI inflammation, is elevated in patients with CF.50 Calprotectin is well correlated with colonic inflammation but appears less reliable for inflammation in the proximal GI tract.55 In one study in patients with CF, calprotectin did not correlate with presumptive small intestinal inflammation resulting from SIBO.56 However, after treatment of whole-gut dysbiosis with probiotics, calprotectin levels decreased suggested improvements in intestinal inflammation.57 A subset of subjects enrolled in the Part B CORE study will provide fecal samples for fecal calprotectin.
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Related to Gastro-Intestinal Inflammation

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  • Influenza Vaccination The parties agree that influenza vaccinations may be beneficial for patients and employees. Upon a recommendation pertaining to a facility or a specifically designated area(s) thereof from the Medical Officer of Health or in compliance with applicable provincial legislation, the following rules will apply:

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  • Infectious Disease Where an employee produces documentary evidence that:

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