Genes Sample Clauses

Genes. A limited amount of research has started to point to the involvement of genes in predicting those who may be more susceptible to nocebo responses. Xxxxx et al. (2014) focussed on the genetic polymorphisms in the catechol-O-methyltransferase (COMT) gene (Val158Met), which has previously been implicated in studies looking at genetic risk factors for patients’ responsiveness to placebo analgesia in irritable bowel syndrome (Hall et al., 2012). They analysed side effects at baseline and after ingestion of a sham immunosuppressive medication in 62 healthy male subjects, and found significantly more side effects were reported from Val/Val homozygous carriers compared to the Val/Met or Met/Met genotype groups (Xxxxx et al., 2014). Xxxxxxxxxxx, Xxxx, Xxxx, and Xxxxxx (2015) notes that this supports a link between the dopaminergic system and nocebo effects, as the val genotype is associated with a 3-4 times higher breakdown of brain dopamine than the met variant of the COMT gene.
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Related to Genes

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