Mechanistic modelling in BOUNCE Sample Clauses

Mechanistic modelling in BOUNCE. In BOUNCE tumor progression, response to pre-operative treatment and relapse following surgery and adjuvant treatment will not be directly attempted in the absence of an imageable tumor at two time points, given that the majority of BOUNCE patients will receive adjuvant therapy. However, it may be possible to exploit tumor data from post-surgery residual tumor tissue. These modelling approaches can also be applied in the case of recurrent cases for the simulation of appearance, progression and response to treatment of the recurrent tumor. However, the incidence of tumor relapse during BOUNCE prospective pilot is expected to be very low, because BOUNCE will consider only stages I, II and III and the follow–up period is short (12- 18 months). Furthermore, no imaging or volumetric data is planned to be gathered or to be made available for BOUNCE purposes. In the context of BOUNCE, the developed mechanistic models will serve as a learning and educational environment that will help disseminate the importance of this type of models to the public, to medical stakeholders, industry and funding agencies. The aim is multifold; to explain the biological mechanisms that govern disease progression and response to different types of treatment (health literacy), to demonstrate how mechanistic models can contribute to the battle against cancer and to promote familiarity with the vocabulary that characterize in silico cancer modelling. The mechanistic models will operate on synthetic data acquired by literature and will produce a simple set of results.
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