Common use of med Clause in Contracts

med. Investigator’s File 1 16 Sep 13 Associated Forms And Templates: 109.5 MED. 01 Investigator´s File Table of Content 1 16 Sep 13 109.5 MED. Electronic Study Folder and Shadow File 109.7 MED.01 Shadow File Coordinators Log 109.7 MED.02 Electronic Folder Names 109.7 MED.03 Example of Electronic Study Folder and Shadow File Structure 1 1 1 1 16 Sep 13 16 Sep 13 16 Sep 13 16 Sep 13 110.1 MED. Clinical Supplies 3 16 Sep 13 Associated Forms And Templates: 110.1 MED. 01 Temperature Log 3 16 Sep 13 110.1 MED. 02 Clinical Supply Shipment Management Log 3 16 Sep 13 110.1 MED. 03 Clinical Supply Accountability Form 3 16 Sep 13 110.1 MED. 04 Re-labelling Report 3 16 Sep 13 110.1 MED. 05 Investigational product RECALL form 3 16 Sep 13 110.1 MED. 06 Investigational product RETURN form 3 16 Sep 13 110.1 MED. 07 Clinical Supply Destruction Report 110.1 MED.08 Site Investigational Product Accountability Log 3 1 16 Sep 13 16 Sep 13 111.1 MED. Clinical Trial Materials 2 30 Sep 13 Associated Forms And Templates: 111.1 MED.01 Trial Supply Shipment Form 4 30 Sep 13 111.1 MED.02 Controlled Copy Distribution Log 3 30 Sep 13 111.1 MED.03 Frozen Samples storage log 3 30 Sep 13 111.1 MED.04 Investigator’s Brochure Acknowledgement of Receipt 2 30 Sep 13 VBL Confidential Information Page 1 of 64 Version 2.2 02 DEC 2013 Portions of this exhibit have been omitted and filed separately with the SEC pursuant to a confidential treatment request and are indicated by [***]. 112.1 MED. Serious Adverse Event Reporting 3 08 Mar 13 Associated Forms And Templates: 112.1 MED. 01 SAE Pregnancy Report Form 3 08 Mar 13 112.2 MED. Distribution of SUSAR reports 2 15 Sep 11 Associated Forms And Templates: 112.2 MED. 01 SUSAR Reports Tracking Log 2 15 Sep 11 112.5 MED. Safety Management Principles 1 16 Sep 2013

med. Translation Associated Forms And Templates: 108.1 MED. 01 Translation Certificate 3 3 19 Sep 11 19 Sep 11 109.1 MED. Clinial Trial Documents 4 16 Sep 13 Associated Forms And Templates: 109.1 MED 01 Essential Documents 4 16 Sep 13 109.3 MED. Trial Master File 1 16 Sep 13 Associated Forms And Templates: 109.2 MED. 01 Trial Maser File Table of Content 1 16 Sep 13 109.2 MED. 02 Trial Maser File and Shadow File Review Form 109.2 MED. 03 TMF Transfer Form 109 3 MED 04 Study Documentation Management Form 1 1 1 16 Sep 13 16 Sep 13 16 Sep 13 109.5 MED. Investigator’s File 1 16 Sep 13 Associated Forms And Templates: 109.5 MED. 01 Investigator´s Investigator’s File Table of Content 1 16 Sep 13 109.5 MED. Electronic Study Folder and Shadow File 109.7 MED.01 Shadow File Coordinators Log 109.7 MED.02 Electronic Folder Names 109.7 MED.03 Example of Electronic Study Folder and Shadow File Structure 1 1 1 1 16 Sep 13 16 Sep 13 16 Sep 13 16 Sep 13 110.1 MED. Clinical Supplies 3 16 Sep 13 Associated Forms And Templates: 110.1 MED. 01 Temperature Log 3 16 Sep 13 110.1 MED. 02 Clinical Supply Shipment Management Log 3 16 Sep 13 110.1 MED. 03 Clinical Supply Accountability Form 3 16 Sep 13 110.1 MED. 04 Re-labelling Report 3 16 Sep 13 110.1 MED. 05 Investigational product RECALL form 3 16 Sep 13 110.1 MED. 06 Investigational product RETURN form 3 16 Sep 13 110.1 MED. 07 Clinical Supply Destruction Report 110.1 MED.08 Site Investigational Product Accountability Log 3 1 16 Sep 13 16 Sep 13 111.1 MED. Clinical Trial Materials 2 30 Sep 13 Associated Forms And Templates: 111.1 MED.01 Trial Supply Shipment Form 4 30 Sep 13 111.1 MED.02 Controlled Copy Distribution Log 3 30 Sep 13 111.1 MED.03 Frozen Samples storage log 3 30 Sep 13 111.1 MED.04 Investigator’s Brochure Acknowledgement of Receipt 2 30 Sep 13 VBL Confidential Information Page 1 91 of 64 101 Version 2.2 02 DEC 2013 Portions of this exhibit have been omitted and filed separately with the SEC pursuant to a confidential treatment request and are indicated by [***]. 112.1 MED. Serious Adverse Event Reporting 3 08 Mar 13 Associated Forms And Templates: 112.1 MED. 01 SAE Pregnancy Report Form 3 08 Mar 13 112.2 MED. Distribution of SUSAR reports 2 15 Sep 11 Associated Forms And Templates: 112.2 MED. 01 SUSAR Reports Tracking Log 2 15 Sep 11 112.5 MED. Safety Management Principles 1 16 Sep 2013

med. Investigator’s File 1 16 Insurance in Clinical Trial Associated Forms And Templates: 114.1 MED. 01 Questionnaire for Insurance Purposes 3 3 15 Apr 13 15 Apr 13 116.1 MED. Clinical Study Report 3 28 Jun 13 Associated Forms And Templates: 116.1MED. 01 Clinical Study Report Tracking Log 3 28 Jun 13 117.1 MED. Archiving Study Files 3 09 Sep 13 Associated Forms And Templates: 109.5 117.1 MED. 01 Investigator´s File Table of Content 1 16 Archiving Facility Log 3 09 Sep 13 109.5 117.1 MED. Electronic 02 Archiving Coordinator Log 2 09 Sep 13 117.1 MED. 03 Archiving Coordinator Backup Log 2 09 Sep 13 117.1 MED. 04 Archiving Coordinator Take Over 2 09 Sep 13 117.1 MED. 05 Post Study Folder and Shadow Checklist 3 09 Sep 13 117.1 MED. 06 Content of Archived Box 2 09 Sep 13 117.1 MED. 07 List of Archived Studies 2 09 Sep 13 117.1 MED. 08 Retrieve from Archives Request 2 09 Sep 13 117.1 MED. 09 Confirmation of Destruction 2 09 Sep 13 117.1 MED. 10 Inventory of Archiving Boxes 2 09 Sep 13 117.1 MED. 11 Inventory of Archiving Locking Seals 2 09 Sep 13 117.1 MED. 12 Content of Archiving File 109.7 MED.01 Shadow File Coordinators Log 109.7 MED.02 Electronic Folder Names 109.7 MED.03 Example 2 09 Sep 13 117.3 MED Management of Electronic Study Folder and Shadow File Structure Correspondence 1 1 1 1 16 Sep 29 Mar 13 16 Sep 13 16 Sep 13 16 Sep 13 110.1 121.1 MED. Clinical Supplies 3 16 Sep 13 Contracts with Investigators and Investigational Sites 4 01 Feb 10 Associated Forms And Templates: 110.1 121.1 MED. 01 Temperature Log 3 16 Sep 13 110.1 Bilateral contract (investigator) 121.1 MED. 02 Clinical Supply Shipment Management Log 3 16 Sep 13 110.1 Bilateral contract (centre) 4 4 08 Aug 11 08 Aug 11 121.1 MED. 03 Clinical Supply Accountability Form 3 16 Sep 13 110.1 MED. 04 Re-labelling Report 3 16 Sep 13 110.1 MED. 05 Investigational product RECALL form 3 16 Sep 13 110.1 MED. 06 Investigational product RETURN form 3 16 Sep 13 110.1 MED. 07 Clinical Supply Destruction Report 110.1 MED.08 Site Investigational Product Accountability Log 3 1 16 Sep 13 16 Sep 13 111.1 MED. Clinical Trial Materials 12Tripartite contract (investigator & centre) – MD 2 30 Sep 13 Associated Forms And Templates: 111.1 MED.01 Trial Supply Shipment Form 4 30 Sep 13 111.1 MED.02 Controlled Copy Distribution Log 3 30 Sep 13 111.1 MED.03 Frozen Samples storage log 3 30 Sep 13 111.1 MED.04 Investigator’s Brochure Acknowledgement of Receipt 2 30 Sep 13 08 Aug 11 VBL Confidential Information Page 1 92 of 64 101 Version 2.2 02 DEC 2013 Portions of this exhibit have been omitted and filed separately with the SEC pursuant to a confidential treatment request and are indicated by [***]. 112.1 121.1 MED. Serious Adverse Event Reporting 13 Bilateral contract (investigator-coordinator) – MD 2 08 Aug 11 122.1 MED. Confidentiality Agreements and Confidentiality Obligation 3 08 14 Mar 13 11 123.1 MED. Principles of drawing contracts and master service agreements 2 28 Mar 11 Associated Forms And Templates: 112.1 123.1 MED. 01 SAE Pregnancy Report Form 3 08 Mar 13 112.2 KCR Group Contract Template: Master Service Agreement 123.1 MED. Distribution of SUSAR reports 02 KCR Group Contract Template: Service Agreement for a clinical study conduct 2 15 1 28 Mar 11 20 Oct 08 124.1 MED. Fraud and Misconduct 3 11 Feb 13 125.1 MED. Purchases Within a Project 1 25 Jul 11 127.1 MED. Legislation in Clinical Trials 2 31 Jul 13 127.3 MED Regulatory Intelligence Associated Forms And Templates: 127.3 MED.01 Regulatory Intelligence Responsibilities 1 1 28 Dec 12 28 Dec 12 128.1 MED. Communication with Subcontractor Associated Forms And Templates: 128.1 MED. 01 Subcontractor Tracking Log 1 1 01 Sep 11 01 Sep 11 129.1 MED. Annual Progress Report to Competent Authorities 2 30 Sep 11 Associated Forms And Templates: 112.2 129.1 MED. 01 SUSAR Reports Tracking Log Annual Progress Report Template 2 15 30 Sep 11 112.5 130.1 MED. Safety Management Principles Preparing Monitoring Plan 1 16 Sep 201325 Nov 11 Associated Forms And Templates: 130.1 MED. 01 Monitoring Plan 1 25 Nov 11 131.1 MED. Communication Plan Associated Forms And Templates: 1 30 Apr 12 131.1 MED. 01 Communication GLOBAL Contact List 1 30 Apr 12 131.1 MED. 02 Communication COUNTRY Contact List 1 30 Apr 12 131.1 MED. 03 Communication VENDOR Contact List 1 30 Apr 12 131.1 MED. 04 Study Team Delegation Log 1 30 Apr 12 VBL Confidential Information Page 93 of 101 Version 2.2 02 DEC 2013 Portions of this exhibit have been omitted and filed separately with the SEC pursuant to a confidential treatment request and are indicated by [***]. 131.1 MED 05 Communication Plan 1 30 Apr 12 132.1 MED. Unbliding 1 28 Aug 12 Associated Forms And Templates: 132.1 MED. 01 Unblinding Contact List 1 28 Aug 12 132.1 MED. 02 Unblinding Report 1 28 Aug 12 132.2 MED. 03 Unblinding Listing 1 28 Aug 12 000.0.XXX Principal Investigator Change 1 04 Apr 13 Associated Forms And Templates: 134 1 MED 01 Principal Investigator Change Checklist 131.1. MED. 03 134 1 MED 02 Letter to Competent Authorities About Principal Investigator Change 1 1 04 Apr 13 04 Apr 13 Portions of this exhibit have been omitted and filed separately with the SEC pursuant to a confidential treatment request and are indicated by [***]. Attachment No. 5 List of third parties engaged by the Sponsor for the conduct of the Study

med. Investigator’s File 1 16 Insurance in Clinical Trial Associated Forms And Templates: 114.1 MED. 01 Questionnaire for Insurance Purposes 3 3 15 Apr 13 15 Apr 13 116.1 MED. Clinical Study Report 3 28 Jun 13 Associated Forms And Templates: 116.1MED. 01 Clinical Study Report Tracking Log 3 28 Jun 13 117.1 MED. Archiving Study Files 3 09 Sep 13 Associated Forms And Templates: 109.5 117.1 MED. 01 Investigator´s File Table of Content 1 16 Archiving Facility Log 3 09 Sep 13 109.5 117.1 MED. Electronic 02 Archiving Coordinator Log 2 09 Sep 13 117.1 MED. 03 Archiving Coordinator Backup Log 2 09 Sep 13 117.1 MED. 04 Archiving Coordinator Take Over 2 09 Sep 13 117.1 MED. 05 Post Study Folder and Shadow Checklist 3 09 Sep 13 117.1 MED. 06 Content of Archived Box 2 09 Sep 13 117.1 MED. 07 List of Archived Studies 2 09 Sep 13 117.1 MED. 08 Retrieve from Archives Request 2 09 Sep 13 117.1 MED. 09 Confirmation of Destruction 2 09 Sep 13 117.1 MED. 10 Inventory of Archiving Boxes 2 09 Sep 13 117.1 MED. 11 Inventory of Archiving Locking Seals 2 09 Sep 13 117.1 MED. 12 Content of Archiving File 109.7 MED.01 Shadow File Coordinators Log 109.7 MED.02 Electronic Folder Names 109.7 MED.03 Example 2 09 Sep 13 117.3 MED Management of Electronic Study Folder and Shadow File Structure Correspondence 1 1 1 1 16 Sep 29 Mar 13 16 Sep 13 16 Sep 13 16 Sep 13 110.1 121.1 MED. Clinical Supplies 3 16 Sep 13 Contracts with Investigators and Investigational Sites 4 01 Feb 10 Associated Forms And Templates: 110.1 121.1 MED. 01 Temperature Log 3 16 Sep 13 110.1 Bilateral contract (investigator) 121.1 MED. 02 Clinical Supply Shipment Management Log 3 16 Sep 13 110.1 Bilateral contract (centre) 4 4 08 Aug 11 08 Aug 11 121.1 MED. 03 Clinical Supply Accountability Form 3 16 Sep 13 110.1 09 Service agreement (single contractor) 121.1 MED. 04 Re-labelling Report 3 16 Sep 13 110.1 10 Bilateral contract (investigator) – MD 121.1 MED. 05 Investigational product RECALL form 3 16 Sep 13 110.1 11 Bilateral contract (centre) – MD 2 2 2 08 Aug 11 08 Aug 11 08 Aug 11 121.1 MED. 06 Investigational product RETURN form 3 16 Sep 13 110.1 MED. 07 Clinical Supply Destruction Report 110.1 MED.08 Site Investigational Product Accountability Log 3 1 16 Sep 13 16 Sep 13 111.1 MED. Clinical Trial Materials 12 Tripartite contract (investigator & centre) – MD 2 30 Sep 13 Associated Forms And Templates: 111.1 MED.01 Trial Supply Shipment Form 4 30 Sep 13 111.1 MED.02 Controlled Copy Distribution Log 3 30 Sep 13 111.1 MED.03 Frozen Samples storage log 3 30 Sep 13 111.1 MED.04 Investigator’s Brochure Acknowledgement of Receipt 2 30 Sep 13 VBL Confidential Information Page 1 of 64 Version 2.2 02 DEC 2013 08 Aug 11 Portions of this exhibit have been omitted and filed separately with the SEC pursuant to a confidential treatment request and are indicated by [***]. 112.1 121.1 MED. Serious Adverse Event Reporting 3 13 Bilateral contract (investigator-coordinator) – MD 2 08 Mar 13 Associated Forms And Templates: 112.1 Aug 11 122.1 MED. 01 SAE Pregnancy Report Form Confidentiality Agreements and Confidentiality Obligation 3 08 14 Mar 13 112.2 11 123.1 MED. Distribution Principles of SUSAR reports drawing contracts and master service agreements 2 15 Sep 28 Mar 11 Associated Forms And Templates: 112.2 123.1 MED. 01 SUSAR Reports KCR Group Contract Template: Master Service Agreement 123.1 MED. 02 KCR Group Contract Template: Service Agreement for a clinical study conduct 2 1 28 Mar 11 20 Oct 08 124.1 MED. Fraud and Misconduct 3 11 Feb 13 125.1 MED. Purchases Within a Project 1 25 Jul 11 127.1 MED. Legislation in Clinical Trials 2 31 Jul 13 127.3 MED Regulatory Intelligence Associated Forms And Templates: 127.3 MED.01 Regulatory Intelligence Responsibilities 1 1 28 Dec 12 28 Dec 12 128.1 MED. Communication with Subcontractor Associated Forms And Templates: 128.1 MED. 01 Subcontractor Tracking Log 2 15 1 1 01 Sep 11 112.5 MED. Safety Management Principles 1 16 01 Sep 201311