Mutation search sensitivities Sample Clauses

Mutation search sensitivities. The second section of the MODEL PARAMETERS Web page (Figure 11) shows the current BRCA1, BRCA2, PALB2, ATM and CHEK2 mutation search sensitivities. Mutation search sensitivities define the proportion of mutations that a mutation search is known to detect. They are expressed as decimal numbers in the range 0 to 1. For example, if you know that your mutation search detects 90% of BRCA1 mutations, you should input 0.9 in the BRCA1 text box on the MODEL PARAMETERS Web page. To change these parameters, select one of the two options on the ‘Set mutation search sensitivities’ selection list: ‘Default’ or ‘Custom’. If you select the ‘Default’ option, default mutation search sensitivities will appear in the adjacent text boxes. If you select the ‘Custom’ option, the program will clear and sensitise the adjacent text boxes, to enable you to input your own settings. ► If you are uncertain how to specify mutation search sensitivities, please contact us for further clarification.
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