Myocardial aerobic metabolism Sample Clauses

Myocardial aerobic metabolism. The contracting myocardium needs a constant supply of adenosine triphosphate (ATP) to meet its high energy demands. Over 95% of ATP utilised by the heart is generated through mitochondrial respiration, and the remainder through glycolysis or guanosine triphosphate (GTP) synthesis from the tricarboxylic acid (TCA) cycle25. The mitochondria utilises substrates from the metabolism of a range of substrates including fatty acids, glucose, lactate, ketones and amino acids in order to generate ATP26. The main pathways involved in myocardial ATP production are described below.
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