New strategies for posaconazole targeted therapy Sample Clauses

New strategies for posaconazole targeted therapy. The finding that posaconazole accumulates in human peripheral blood mononuclear cells and polymorphonuclear leukocytes triggered an investigation on the impact of posaconazole-loaded leukocytes on the antifungal activity and functional capacity of different leukocytes [117-120]. High posaconazole intracellular concentrations did not show a significant impact on the functional capacities of human neutrophils and macrophages in vitro [118]. Natural killer cells also have proven to still be viable and they maintained their capacity under therapeutic concentration of posaconazole [120]. Similar results were also found in neutrophil-like leukocyte cells. Furthermore, an improved antifungal activity was observed both in vitro and in an in vivo mouse model with invasive pulmonary aspergillosis, which indicates the potential of posaconazole-loaded leukocytes as a novel antifungal strategy, in which leukocytes serve as a vehicle to target the infection site and further increase the antifungal effect [119]. Apart from this, these endogenous vehicles are supposed to be associated with less safety problems and are considered as a promising strategy for the prophylaxis and treatment of IFD.
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