Non-endocytic pathways Sample Clauses

Non-endocytic pathways. Work has suggested that pDNA/lipid complexes enter cells via fusion with the cellular membrane and direct release of pDNA into the cytosol before entering the endosomal compartment (Xxxxxxx, X.X. xx al., 1994). This mechanism has an advantage over endocytosis in that it can avoid lysosomal degradation. However fusion has been found to only participate minimally in the uptake of gene delivery vectors (Friend, D.S. et al., 1996, Xxxxxx, X. et al., 2005). Another non-endocytic process is an energy-independent direct penetration of the lipid bilayer, which has been used as an internalisation route for pDNA/peptides complexes (Xxxxxx, X.X. et al., 2003, Xxxxxx, R. and H.P. Xxxxxx, 2004). Recently Xx and colleagues (2009) suggested that although 95% of siRNA/lipid complexes entered the cells via endocytosis, they were not functional in inducing gene silencing and it was the 5% of complexes that entered via a different mechanism that resulted in efficient gene silencing. They suggested that the mechanism followed by the functional complexes was passive diffusion across the cellular membrane.
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Related to Non-endocytic pathways

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