Redox responsive Sample Clauses

Redox responsive. Disulphide bonds, prone to rapid cleavageby glutathione (GSH), can be used to attain redox sensitivity as a high redox potential difference (∼ 100–1000 fold) exists between the reducing intracellular space and oxidizing extracellular space (Xxxxx et al., 2003). For example, a thiomer-based nanoparticulate gene delivery system was developed (Xxxxxxx et al., 2007). Thiol groups prone to oxidation were immobilized on the polymeric backbone of chitosan in order to incorporate the property of extracellular stability and intracellular gene release by forming reversible disulfide bonds. The highest efficiency was observed in transfection studies performed in a Caco-2 cell culture. GSH-sensitive crosslinking agents can be incorporated in the core of the micelles, leading to rapid micelle disassembly followed by specific intracellular release of hydrophobic drugs (Xx et al., 2011). In addition, liposomes are the candidates for redox-sensitive systems as well (Ong et al., 2008). However, designing these systems to be sensitive to discrete variations of pH and redox potential is not straightforward.
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