Rotavirus replication Sample Clauses

Rotavirus replication. RV replication has been widely studied but not completely understood; replication is similar to other dsRNA viruses and Xxxxxxxxxxxx discusses RV replication in greater detail in Rotaviruses: Methods and Protocols (3). RV, upon binding to receptors, enters the cell by either receptor-mediated endocytosis or direct penetration. Once in the cytoplasm, a viroplasm is formed where transcription of VPs and NSPs and replication takes place. Double- layered particles assemble followed by triple-layered particles, and the virion further matures with VP7 glycosylation. The virion releases upon cell lysis (3).
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