Structure and assembly of amyloid Sample Clauses

Structure and assembly of amyloid.  The A is formed after sequential cleavage of the APP by the - and -secretases in a two step process.5,11 As shown in Figure 1.1.1, APP is first cleaved by -secreatase, which allows for the APP large ectodomain to be released into the extracellular fluid, leaving a membrane-bound C-terminal fragment.5 The remaining portion of the APP (99 amino acids) is then cleaved by -secreatase to produce A, which is then released in the extracellular space.
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