Supervised Consumption of Espranor Sample Clauses

Supervised Consumption of Espranor. The administration of Espranor is different to other buprenorphine products as it is placed on the tongue (not under it). Median time for disintegration is 2 minutes. Espranor contains gelatin whereas the other buprenorphine tablets do not. This may need to be considered for certain patients. The initial dose of Espranor is 2mg compared to 0.8mg – 4mg for other oral buprenorphine preparations and the maximum single daily dose for Espranor is 18mg NOT 24mg or 32mg as with Suboxone and Subutex. The oral lyophilisate should be removed from the blister pack with dry fingers – any contact with moisture will result in disintegration of the wafer. The oral lyophilisate must be placed whole on the tongue until dispersed. This is different to current buprenorphine tablets which are placed under the tongue. Healthcare professionals need to be clear about this to advise patients and avoid administration errors. Placing Espranor on the tongue makes supervision of dosing easier as it instantly begins to disintegrate making removal from the mouth for the purposes of diversion impossible. If the oral lyophilisate or saliva containing buprenorphine is swallowed, the buprenorphine will be metabolised, excreted and have minimal effect. Swallowing should be avoided for 2 minutes. Food and drink should not be consumed for 5 minutes after administration. This requires observation of people having supervised consumption.
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