Syncytiotrophoblast Sample Clauses

Syncytiotrophoblast. The placenta is made up of the embryonic chorion and maternal decidua basalis. There are three main layers of the chorion: the extraembryonic mesoderm contains the blood vessels that supply the developing embryo, and the cytotrophoblast and syncytiotrophoblast drive invasion of the endometrium and myometrium, securing access to maternal oxygen and nutrients. The syncytiotrophoblast forms by fusion of terminally differentiated cytotrophoblast cells (Huppertz and Gauster 2011). Nuclei within the syncytiotrophoblast differ in transcriptional activity and chromatin organization. Assaying several markers of transcriptional activity revealed variation among nuclei, including some nuclei that were negative for all markers examined (Xxxxxx, Cindrova-Davies et al. 2009). Similarly, nuclei differed in chromatin organization: some nuclei have open chromatin while others have high levels of heterochromatin (Xxxxxxx, Xxxxxxxx-Xxxxx et al. , Xxxxxx, Cindrova-Davies et al. 2009). High levels of clustered nuclei with dense chromatin is associated with prenatal pathologies, including eclampsia (Xxxxxx 2014). These clusters of nuclei are exacerbated by hypoxia (Heazell, Xxxx et al. 2007). Nuclei with dense chromatin tended to be those with no detectable transcriptional activity. These nuclei could be older defunct nuclei or condensed chromatin, and lack of transcription could be markers of dead or dying nuclei.
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