Transverse relaxation mapping Sample Clauses

Transverse relaxation mapping. Intrinsic MR parameters, such as transverse (T2) relaxation times are sensitive to changes in the biophysical environment of water, and are thought to be affected during impared cell physiology. Disease mechanisms influence the composition of tissue, and can have an effect on the tissue specific relaxation rates. Thus T2 mapping can be used to diagnose or predict disease. For example, T2 mapping can be used to delineate the disease volume. The regional distribution of T2 values within a tumor is a measure of the tissue heterogeneity within the tumor volume (42). In addition, the large differences in T2 relaxation times between normal and diseased tissue can be used in a computer algorithm to automatically demarcate the boundary of abnormal tissue. Since the polarization present in the xy-plane depends on T2, while different T2-weighting factors are obtained by modifying the TE value of a spin echo technique, it is possible to calculate the value of T2 from a series of SE images with different echo times. As the signal intensity in these images is related to the magnetization in the xy plane, T2 can be calculated by substituting the measured signal intensity for Mxy(t), according to M xy (t) = M xymax − t
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