Xxxxxxx Pharmaceutica NV Sample Clauses

Xxxxxxx Pharmaceutica NV. Xxxxxxx’x interests are in developing and using advanced molecular simulation methods to optimize lead compounds in discovery programs. Such methods, if proven robust and accurate could have a profound impact on the way drug discovery is performed. They would permit reliable computational triaging of very close analogue molecules greatly improving efficiency. Also, this would lead to high-confidence design of synthetically more challenging molecules leading to better drugs in new chemical space. Also, we envisage the accurate prediction of compound binding for targets that have mutated residues. This latter application can be of value in diagnostics, by predicting the best possible compound for a patient clinically (personalised medicine), but is also of use in discovery, where mutated targets occur regularly in antibacterials, antivirals, and oncology compounds. Xxxxxxx has been actively collaborating with UCL on calculation of free energies of binding on public and on Xxxxxxx internal compound sets (targets BRD4, LDHA and PDE2). A manuscript has been co-written and just accepted for publication on the BRD4 application. A second manuscript is under preparation describing the LDHA application. Both cases have led to learnings about the suitable application of MMPBSA, so called ESMACS approach, for the calculation of binding free energies. A third large and extensive study has been mostly completed and in the early stages of write up for publication. This study has involved the use of alchemical perturbation methods, the TIES approach was performed at the UCL group, and the FEP+ approach at Xxxxxxx. Results have been performed for multiple perturbations from various different protein targets. A particular focus has been to investigate the precision of both methods when submitted to extensive repeated trial calculations. The TIES work has also required new replica exchange methodology recently implemented for TIES in the Xxxxxxx group [21, 22, 23]. Within Xxxxxxx, they evaluated the use of GROMACS for Free Energy Perturbation. They streamlined the application of FEP with GROMACS with the help of HPC experts at SURFsara and ran calculations on the Cartesius system also at SURFsara. Calculations were performed and compared with Xxxxxxxxxxx’s FEP+ software. We studied multiple datasets, generating lots of valuable insights on the strengths and limitations of GROMACS FEP. Parts of this work were included in our recent publication [24]. Xxxxxxx completed a study ...
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Related to Xxxxxxx Pharmaceutica NV

  • INDUSTRIAL PRODUCTS ARTICLE 3

  • Xxxxxxx, P E./Project Manager / / Date ( ) - Phone CHIEF EXECUTIVE OFFICER AND CHIEF FINANCIAL OFFICER CERTIFICATION: Pursuant to Section VI. B. and VI. C. of the Agreement, the undersigned Chief Executive Officer and Chief Fiscal Officer of the Recipient, as both are designated in Appendix B of the Agreement, hereby request the Director to disburse financial assistance moneys made available to Project in Appendix C of the Agreement (inclusive of any amendment thereto) to the payee as identified below in the amount so indicated which amount equals the product of the Disbursement Ratio and the dollar value of the attached cost documentation which was properly billed to the Recipient in exclusive connection with the performance of the Project. The undersigned further certify that:

  • Xxxxxx and Recall An employee in receipt of notice of layoff pursuant to 9.08(A)(a)(ii) may:

  • Xxxxxxxx, P E., P.S./City Engineer / / Date ( ) - Phone CHIEF EXECUTIVE OFFICER AND CHIEF FINANCIAL OFFICER CERTIFICATION: Pursuant to Section VI. B. and VI. C. of the Agreement, the undersigned Chief Executive Officer and Chief Fiscal Officer of the Recipient, as both are designated in Appendix B of the Agreement, hereby request the Director to disburse financial assistance moneys made available to Project in Appendix C of the Agreement (inclusive of any amendment thereto) to the payee as identified below in the amount so indicated which amount equals the product of the Disbursement Ratio and the dollar value of the attached cost documentation which was properly billed to the Recipient in exclusive connection with the performance of the Project. The undersigned further certify that:

  • Xxxxxx, P A., special counsel for IMC, in IMC's capacity as both Seller and Servicer under the Sale and Servicing Agreement, and/or Xxxxx & Xxxxxx LLP shall have furnished to the Underwriters their written opinion or opinions, addressed to the Underwriters and the Depositor and dated the Closing Date, in form and substance satisfactory to the Underwriters, to the effect that:

  • Technology Research Analyst Job# 1810 General Characteristics Maintains a strong understanding of the enterprise’s IT systems and architectures. Assists in the analysis of the requirements for the enterprise and applying emerging technologies to support long-term business objectives. Responsible for researching, collecting, and disseminating information on emerging technologies and key learnings throughout the enterprise. Researches and recommends changes to foundation architecture. Supports research projects to identify and evaluate emerging technologies. Interfaces with users and staff to evaluate possible implementation of the new technology in the enterprise, consistent with the goal of improving existing systems and technologies and in meeting the needs of the business. Analyzes and researches process of deployment and assists in this process.

  • USOC SOMEC XXXXX Note: In addition to the OSS charges, applicable discounted service order and related discounted charges apply per the tariff.

  • SHOP XXXXXXX (a) The Union may elect or appoint a Shop Xxxxxxx or Shop Stewards to represent the employees and the Union shall notify the Company as to the name or names of such Shop Xxxxxxx or Shop Stewards. The Company agrees that no Shop Xxxxxxx shall suffer any discrimination by reason of holding such office.

  • Research, Science and Technology Cooperation 1. The aims of cooperation in research, science and technology, carried out in the mutual interest of the Parties and in compliance with their policies, will be: (a) to build on existing agreements already in place for cooperation on research, science and technology; (b) to encourage, where appropriate, government agencies, research institutions, universities, private companies and other research organizations in the Parties to conclude direct arrangements in support of cooperative activities, programs or projects within the framework of this Agreement, specially related to trade and commerce; and (c) to focus cooperative activities towards sectors where mutual and complementary interests exist, with special emphasis on information and communication technologies and software development to facilitate trade between the Parties. 2. The Parties will encourage and facilitate, as appropriate, the following activities including, but not limited to:

  • Xxxxxxxx, 121 Cal App.4th Supp. 7 (2004), CIV Code 1962 Colorado $50.00 or 5% of past due rent C.R.S. § 00-00-000 Connecticut Not defined No statute Delaware 5% of the monthly rent amount Title 25, § 5501(d) Florida Not defined No statute Georgia “All contracts for rent shall bear interest from the time the rent is due” Hawaii 8% of the monthly rent amount § 521-21(f) Idaho Not defined No statute Illinois Outside Chicago – Not defined Chicago only – $10.00 per month for the first $500.00 in monthly rent plus five percent per month for any amount in excess of $500.00 in monthly rent for the late payment of rent. No statute 5-12-140(h) Indiana Not defined No statute Iowa If the rent does not exceed $700/month, the late fee cannot exceed more than $12/day per day or $60/month. If the rent is greater than $700/month, the late cannot exceed more than $20/day or $100/month.

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