Short Acting Coagulation Cascade Aptamer definition

Short Acting Coagulation Cascade Aptamer if it Modulates functions other than the blood coagulant function of a Coagulation Cascade Protein; provided, that, it Modulates the blood coagulant function of a Coagulation Cascade Protein.
Short Acting Coagulation Cascade Aptamer means ARC 2172 and any other Aptamer that: (a) binds to a pre-selected Coagulation Cascade Protein identified on Exhibit B; (b) Modulates the blood coagulant function of any Coagulation Cascade Protein identified on Exhibit B; and (c) demonstrates the short-acting characteristics and limitations that are set forth in Exhibit C. For clarity, Short Acting Coagulation Cascade Aptamers do not include [***] Nothing in this Section 1.84 will be interpreted to exclude an Aptamer from the definition of “Short Acting Coagulation Cascade Aptamer” if it Modulates functions other than the blood coagulant function of a Coagulation Cascade Protein; provided, that, it Modulates the blood coagulant function of a Coagulation Cascade Protein.
Short Acting Coagulation Cascade Aptamer any Aptamer that: (a) binds to a pre-selected Coagulation Cascade Protein; (b) Inhibits the blood coagulant function of the pre-selected Coagulation Cascade Protein; and (c) demonstrates the short-acting characteristics and limitations that are set forth in Exhibit C. For clarity, Short Acting Coagulation Cascade Aptamers do not include [ * ].

Examples of Short Acting Coagulation Cascade Aptamer in a sentence

  • If Archemix becomes aware of any Valid Claim owned or controlled by a Third Party that may be infringed by the manufacture, use or sale of any Short Acting Coagulation Cascade Aptamer in the Field during the Term, Archemix will notify Nuvelo.

  • In addition, if Archemix discovers any Short Acting Coagulation Cascade Aptamer for use within the Field or makes any new invention relating to any Short Acting Coagulation Cascade Aptamer for use within the Field in the course of its Research under this Agreement, Archemix will transfer all responsibility for the filing, prosecution and maintenance of the relevant Compound Patent Rights to Nuvelo and will provide Nuvelo with all necessary documents and information to effect the transfer of responsibility.

  • If Archemix becomes aware of any Valid Claim owned or controlled by a Third Party that may be infringed by the manufacture, use or sale of any Short Acting Coagulation Cascade Aptamer in the Field during the Team, Archemix will notify Nuvelo.

  • In addition, if Archemix discovers any Short Acting Coagulation Cascade Aptamer for use within the Field or makes any new invention relating to any Short Acting Coagulation Cascade Aptamer for use within the Field in the course of its Research under this Agreement, Archemix will transfer all responsibility for the filing, prosecution and maintenance of the relevant Compound Patent Rights to Nuvelo and will provide.


More Definitions of Short Acting Coagulation Cascade Aptamer

Short Acting Coagulation Cascade Aptamer if the Aptamer has (i) a Mean Resident Time in normal primates (human or non-human) of less than or equal to seventy-five (75) minutes or (ii) a time to return from a steady state of a therapeutically useful level of anticoagulation (as measured by a monitoring test appropriate for the target, (i.e., ACT, PTT, or PT)) to one hundred twenty percent (120%) of baseline of less than or equal to one hundred twenty (120) minutes in normal primates (human or non-human), in each case, without the administration of another molecule. For purposes of clarification, (y) neither of the parameters in (i) or (ii) above may be achieved through any means other than the administration of the Short Acting Coagulation Cascade Aptamer such as the administration of another secondary or antidote molecule, and (z) any Aptamer that meets the Mean Resident Time criteria set forth above in normal primates (human or non-human) shall be considered a Short Acting Coagulation Cascade Aptamer regardless of the Mean Resident Time in renally or hepatically impaired primates (human or non-human). Mean Resident Time is a pharmacokinetic measure of the average time a molecule remains in the body. For the purposes of establishing the MRT under this Agreement, MRT will be calculated based on plasma concentration data obtained following a single IV bolus dose in primates (human or non-human) using the formula MRT=AUMC/AUC. Tissue Factor, Factor VII, Factor VIIa, Factor X, Factor Xa, Factor XI, Factor XIa, Factor IX, Factor IXa, Factor VIII, Factor VIIIa, Factor V, Factor Va, Factor XIII, Factor XIIIa, Factor XII, Factor XIIa, Fibrinogen and Fibrin, Thrombin and Prothrombin. Factor XIII Fibrin Stabilizing Factor Factor XII Xxxxxxx Factor Factor XI Plasma Thromboplastin Antecedent Factor X Stuart-Prower Factor; Prothrombinase ATIII Antithrombin III; Antithrombin Heparin CoFactor II Heparin Cofactor A Factor IX Christmas Factor Factor VIII Anti-Hemophilic Factor Factor VII Proconvertin Factor V Proaccelerin; Labile Factor Factor II Thrombin; Prothrombin Factor I Fibrinogen Plasminogen Profibrinolysin Plasmin Fibrinolysin Tissue Plasminogen Activator N/A Urokinase Urokinase-Type Plasminogen Activator TFPI Tissue Factor Pathway Inhibitor, Lipoprotein-Associated Coagulation Inhibitor (XXXX), Extrinsic Pathway Inhibitor (EPI) Protein C Autoprothrombin IIA; Blood Coagulation Factor XIV Protein S N/A Thrombomodulin CD141; BDCA-3 Protein Z PROZ ZPI Protein Z-Dependent Protease Inhibitor [**] Confidential ...
Short Acting Coagulation Cascade Aptamer means ARC 2172 and any other Aptamer that: (a) binds to a pre-selected Coagulation Cascade Protein identified on Exhibit B; (b) Modulates the blood coagulant function of any Coagulation Cascade Protein identified on Exhibit B; and (c) demonstrates the short-acting characteristics and limitations that are set forth in Exhibit C. For clarity, Short Acting Coagulation Cascade Aptamers do not include [ [*] Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities and Exchange Act of 1934, as amended.

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